Article
Chemistry, Organic
Nida Sezin Colak, Erbay Kalay, Engin Sahin
Summary: The study successfully demonstrated the bioreduction of aromatic and heteroaromatic ketones into optically active alcohols using Lactobacillus senmaizukei as a whole-cell catalyst. The method showed good performance in terms of yields and enantioselectivity.Furthermore, the findings indicate that L. senmaizukei is a promising biocatalyst for the asymmetric reduction of both 6-membered and 5-membered heteroaromatic methyl ketones, offering a green and cost-effective approach for the synthesis of biologically important chiral alcohols.
SYNTHETIC COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Tao Wang, Xiao-Yan Zhang, Yu-Cong Zheng, Yun-Peng Bai
Summary: A carbonyl reductase variant, SmCRM5, obtained from Serratia marcescens through structure-guided directed evolution, showed improved specific activity towards multiple substrates and high stereoselectivities in the asymmetric synthesis of gamma-/delta-lactones.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Tamara M. de Winter, Jaddie Ho, Christopher J. Alridge, Philip G. Jessop
Summary: A new methodology for asymmetric hydrogenation of allylamines is proposed using a reversible reaction between amines and carbon dioxide (CO2) to suppress unwanted side reactions. The effects of various parameters on the enantioselectivity and conversion were studied, and it was found that the addition of base additives can improve the enantioselectivity and chemoselectivity of the reaction.
Article
Chemistry, Multidisciplinary
Hyotaik Kang, Chao-Jun Li
Summary: This study presents the use of umpolung aldehydes as carbanion equivalents for highly regioselective 1,6-conjugate addition reactions to unsaturated ketones, with initial investigation into the enantioselective variant. It was found that the synergy of ruthenium(ii) catalyst and electron-rich, bidentate phosphine ligand is crucial for enhancing reactivity and selectivity under mild reaction conditions.
Article
Chemistry, Organic
Dmitri Trubitson, Jevgenija Martonova, Marina Kudrjasova, Kristin Erkman, Ivar Jarving, Tonis Kanger
Summary: An efficient enantioselective organocatalytic method has been developed for the synthesis of N-alkylated indoles with alpha-branched alkyl substituents from unsaturated indolyl ketones via a Michael addition. The resulting products exhibit high enantioselectivities and good yields, with tolerance towards various nucleophiles and substitution patterns of the indole ring. Both electron-withdrawing and electron-donating substituents can be accommodated at any position of the heteroaromatic ring.
Article
Chemistry, Multidisciplinary
Feixia Liu, Jie Ren, Lu Guo, Yang Liu, De-Feng Li, Bo Yu
Summary: This study successfully achieved the enantioselective synthesis of S-PGB by engineering d-hydantoinase, avoiding the generation of pollutants in the process. The best variant demonstrated a high conversion rate and chiral selectivity in kilogram scale synthesis, offering a novel green and efficient route for S-PGB production.
Article
Chemistry, Multidisciplinary
Anandarao Munakala, Mandalaparthi Phanindrudu, Rambabu Chegondi
Summary: The development of transition-metal catalyzed enantioselective and diastereoselective transformations has led to significant advances in synthetic organic chemistry, with a focus on the stereoselective desymmetrization of prochiral cyclohexadienones. In recent years, several research groups have made progress in this area, utilizing a variety of transition-metal catalysts to access highly functionalized and stereochemically enriched scaffolds.
Article
Chemistry, Organic
Hui Yang, Yan Li, Wenhui Zhang, Jiayan Song, Jingyu Hu, Mengya Wang, Han Yao, Xia Xu, Na Li, Yanbo Yang, Rongrong Yu, Shuxia Xie, Cuiying Ye, Guo Wei
Summary: A novel regioselective hydrodeoxygenation method for alpha-diketones using phosphites as the deoxygenation reagent was achieved through visible-light photoredox catalysis. The method demonstrated a wide range of substrate compatibility and high functional group compatibility. Unsymmetric alpha-diketones were selectively reduced at the carbonyls of higher electrophilicity, providing a practical complementary approach for the monohydrodeoxygenation of alpha-diketones compared to existing methods.
Article
Chemistry, Organic
Jia-Yin Wang, Guigen Li, Wen-Juan Hao, Bo Jiang
Summary: A new asymmetric catalytic conjugate reduction method has been established for synthesizing enantioenriched cyclobuta[a]-naphthalen-4(2H)-ones using copper-bisphosphine complexes as catalysts, providing excellent regio- and enantioselectivities. This protocol is tolerant to a broad scope of substrates, exhibits high compatibility with various substituents, and offers excellent stereoselectivity.
Article
Chemistry, Multidisciplinary
Lei Wang, Wenxin Lu, Jiwu Zhang, Qinglei Chong, Fanke Meng
Summary: In this study, an unprecedented cobalt-catalyzed regio-, diastereo- and enantioselective hydrosilylation of 1,3-dienes is presented, enabling the simultaneous construction of a carbon- and a silicon-stereogenic center. The generated chiral silanes exhibit high efficiency and stereoselectivity, and can be further functionalized to obtain valuable chiral building blocks.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Yunfeng Cui, Liangyan Zhu, Xi Chen, Jinhui Feng, Qiaqing Wu, Dunming Zhu
Summary: The study demonstrated a method for synthesizing the key precursor for ruxolitinib using PhADH to bioreduce 3-cyclopentyl-3-ketopropanenitrile. Rational engineering of the PhADH enzyme led to the double mutant H93C/A139L, which showed improved enantioselectivity and specific activity. This mutant enzyme was found to be effective in reducing beta-substituted-beta-ketonitriles at high concentrations.
Review
Chemistry, Physical
Auwal Eshi Sardauna, Muhammad Abdulrasheed, Alexis Nzila, Musa M. Musa
Summary: Biocatalytic asymmetric reduction of prochiral bulky-bulky ketones is a challenging task due to the subtle differences in size of their alkyl or aryl groups. This review summarizes recent examples of this transformation and proposes strategies to improve its efficiency.
MOLECULAR CATALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Miaomiao Zhang, Hongmei Jiao, Haojie Ma, Ran Li, Bo Han, Yuqi Zhang, Jijiang Wang
Summary: A convenient method for the synthesis of alcohols using zinc catalysis has been reported. It does not require acid or base hydrolysis reagents and has high selectivity and scalability, as well as tolerance towards sensitive functionalities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Sebastian Armin Schwengers, Gabriela Guillermina Gerosa, Tynchtyk Amatov, Naoki Yasukawa, Sebastian Brunen, Markus Leutzsch, Benjamin Mitschke, Grigory Andre Shevchenko, Benjamin List
Summary: We report a highly selective and catalytic one-step dehydrogenation of alpha-substituted cyclic ketones using 2,3-dichlorobenzo-5,6-dicyano-1,4-benzoquinone (DDQ). The selectivity is achieved through phosphoric acid-catalyzed enolization, selectively forming the thermodynamically preferred enol, followed by oxidation. This method provides a reliable access to various alpha-aryl and alpha-alkyl substituted alpha,beta-unsaturated ketones.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Organic
Xu-Long Qin, Li-Jun Xu, Fu-She Han
Summary: Chiral alcohols are important intermediates for synthesizing drugs, agrochemicals, and natural products. Asymmetric reduction of prochiral ketones is the most investigated method for obtaining chiral alcohols. Organocatalyzed asymmetric reduction, as a complementary method to transition-metal- and enzyme-catalyzed reactions, has gained significant interest due to its metal-free nature, ease of operation, and catalyst recovery and reuse.
SYNTHESIS-STUTTGART
(2022)
Article
Engineering, Environmental
Patricia A. Lucero, Monica M. Ferrari, Alejandro A. Orden, Irene Canas, Mirtha Nassetta, Marcela Kurina-Sanz
JOURNAL OF HAZARDOUS MATERIALS
(2016)
Article
Biochemistry & Molecular Biology
M. Laura Mascotti, Martin A. Palazzolo, Fabricio R. Bisogno, Marcela Kurina-Sanz
Review
Biotechnology & Applied Microbiology
Martin A. Palazzolo, Marcela Kurina-Sanz
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2016)
Article
Biotechnology & Applied Microbiology
Cynthia Magallanes-Noguera, Francisco M. Cecati, Maria Laura Mascotti, Guillermo F. Reta, Elizabeth Agostini, Alejandro A. Orden, Marcela Kurina-Sanz
JOURNAL OF BIOTECHNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Francisco M. Cecati, Cynthia Magallanes-Noguera, Carlos E. Tonn, Carlos E. Ardanaz, Marcela Kurina-Sanz
PROCESS BIOCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Celeste Aguirre-Pranzoni, Rodrigo D. Tosso, Fabricio R. Bisogno, Marcela Kurina-Sanz, Alejandro A. Orden
PROCESS BIOCHEMISTRY
(2019)
Article
Chemistry, Organic
Adrian A. Heredia, Martin G. Lopez-Vidal, Marcela Kurina-Sanz, Fabricio R. Bisogno, Alicia B. Penenory
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Biotechnology & Applied Microbiology
Martin A. Palazzolo, Pablo D. Postemsky, Marcela Kurina-Sanz
Article
Biotechnology & Applied Microbiology
Jainara Santos Do Nascimento, Felipe Moura Silva, Cynthia Alejandra Magallanes-Noguera, Marcela Kurina-Sanz, Elda Goncalves Dos Santos, Ivo Santana Caldas, Jaine Honorata Hortolan Luiz, Eliane de Oliveira Silva
FOLIA MICROBIOLOGICA
(2020)
Article
Biotechnology & Applied Microbiology
Abi L. Anello, Leonardo Aguilera, Marcela Kurina-Sanz, Maximiliano Juni Ayub, Maria Laura Mascotti
ENZYME AND MICROBIAL TECHNOLOGY
(2020)
Article
Chemistry, Applied
Francisco M. Cecati, Fabricio D. Cid, Carlos Ardanaz, Marcela Kurina-Sanz
Summary: The volatile compounds of Eupatorium buniifolium were analyzed by SPME, revealing differences in composition between fresh plant aroma, essential oil, and extracts obtained using organic solvents.
JOURNAL OF ESSENTIAL OIL RESEARCH
(2021)
Article
Environmental Sciences
Martin A. Palazzolo, Maximiliano M. Aballay, Antares A. Martinez, Marcela Kurina-Sanz
Summary: This study demonstrated the preparation of lipophilic extracts from grape stalks of different grape varieties as biocontrol agents against pathogenic fungi in various fruit trees. One specific extract showed broad biocontrol spectrum against multiple fungal pathogens.
WASTE AND BIOMASS VALORIZATION
(2022)
Article
Environmental Sciences
Patricia A. Lucero, Cynthia Magallanes-Noguera, Fernando A. Giannini, Mirtha Nassetta, Alejandro A. Orden, Marcela Kurina-Sanz
Summary: This study assessed the removal, bioaccumulation, and metabolization of the insecticide endosulfan by hairy root clones of Brassica napus, Raphanus sativus, and Capsicum annuum. The results showed that these plants have the potential to remove and metabolize endosulfan, and the treated water did not cause mortality in the tested fish.
INTERNATIONAL JOURNAL OF PHYTOREMEDIATION
(2023)
Article
Biotechnology & Applied Microbiology
Maria Soledad Diaz-Gabutti, Cynthia Magallanes-Noguera, Francisco Miguel Cecati, Monica Ferrari, Jorge Leporati, Patricia Verdes, Marcela Kurina-Sanz
Summary: High multiplication rates of Hedeoma multiflora Benth. were achieved through in vitro propagation without using plant growth regulators (PGRs). The morpho-anatomical and chemical features of the in vitro plants were similar to those of wild specimens. In vitro biomass production in a PGR-free medium is an appropriate technology to reduce the overexploitation of endangered wild populations and avoid health safety issues related to the edible consumption of the species.
PLANT CELL TISSUE AND ORGAN CULTURE
(2023)
Article
Chemistry, Multidisciplinary
Florencia Carmona-Viglianco, Daniel Zaragoza-Puchol, Oscar Parravicini, Adriana Garro, Ricardo D. Enriz, Gabriela E. Feresin, Marcela Kurina-Sanz, Alejandro A. Orden
NEW JOURNAL OF CHEMISTRY
(2020)