Methods and options for the heterologous production of complex natural products

Genetically Engineered Lipopeptide Antibiotics Related to A54145 and Daptomycin with Improved Properties

(2010) K. T. Nguyen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Formation and Attachment of the Deoxysugar Moiety and Assembly of the Gene Cluster for Caprazamycin Biosynthesis

(2010) L. Kaysser et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Heterologous Expression of the Oxytetracycline Biosynthetic Pathway in Myxococcus xanthus

(2010) D. C. Stevens et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Use of an inducible promoter for antibiotic production in a heterologous host

(2010) Volker Dangel et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Cloning and Characterization of the Ravidomycin and Chrysomycin Biosynthetic Gene Clusters

(2010) Madan K. Kharel et al.   CHEMBIOCHEM

Isolation of the lysolipin gene cluster of Streptomyces tendae Tü 4042

(2010) Patricio Lopez et al.   GENE

Cloning, Sequencing, Heterologous Expression, and Mechanistic Analysis of A-74528 Biosynthesis

(2010) Kathia Zaleta-Rivera et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Natural Products Version 2.0: Connecting Genes to Molecules

(2010) Christopher T. Walsh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel Anti-Infective Compounds from Marine Bacteria

(2010) Hafizur Rahman et al.   Marine Drugs

Marine natural products

(2010) John W. Blunt et al.   NATURAL PRODUCT REPORTS

Integration of stable extracellular DNA released from Escherichia coli into the Bacillus subtilis genome vector by culture mix method

(2010) Mitsuhiro Itaya et al.   NUCLEIC ACIDS RESEARCH

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

(2010) M. Komatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome

(2010) D. G. Gibson et al.   SCIENCE

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Determination of the extent of phosphopantetheinylation of polyketide synthases expressed in Escherichia coli and Saccharomyces cerevisiae

(2009) Ka Kit Michael Lee et al.   ANALYTICAL BIOCHEMISTRY

The Biosynthetic Logic of Polyketide Diversity

(2009) Christian Hertweck   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biosynthesis of Plant Isoprenoids: Perspectives for Microbial Engineering

(2009) James Kirby et al.   Annual Review of Plant Biology

Adaptation of the Highly Productive T7 Expression System to Streptomyces lividans

(2009) F.-X. Lussier et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Biosynthesis and biotechnological production of flavanones: current state and perspectives

(2009) Zachary L. Fowler et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Functional expression of the Aspergillus flavus PKS–NRPS hybrid CpaA involved in the biosynthesis of cyclopiazonic acid

(2009) Yasuyo Seshime et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biosynthesis of the proteasome inhibitor syringolin A: the ureido group joining two amino acids originates from bicarbonate

(2009) Christina Ramel et al.   BMC BIOCHEMISTRY

Deciphering Pactamycin Biosynthesis and Engineered Production of New Pactamycin Analogues

(2009) Takuya Ito et al.   CHEMBIOCHEM

Cloning and Heterologous Expression of the Cyclooctatin Biosynthetic Gene Cluster Afford a Diterpene Cyclase and Two P450 Hydroxylases

(2009) Seung-Young Kim et al.   CHEMISTRY & BIOLOGY

Daptomycin: mechanisms of action and resistance, and biosynthetic engineering

(2009) Richard H Baltz   CURRENT OPINION IN CHEMICAL BIOLOGY

Chasing the treasures of the sea—bacterial marine natural products

(2009) Tobias AM Gulder et al.   CURRENT OPINION IN MICROBIOLOGY

Gene Cluster Involved in the Biosynthesis of Griseobactin, a Catechol-Peptide Siderophore of Streptomyces sp. ATCC 700974

(2009) S. I. Patzer et al.   JOURNAL OF BACTERIOLOGY

Engineering of plant-specific phenylpropanoids biosynthesis in Streptomyces venezuelae

(2009) Sung Ryeol Park et al.   JOURNAL OF BIOTECHNOLOGY

Advances in the Understanding and Use of the Genomic Base of Microbial Secondary Metabolite Biosynthesis for the Discovery of New Natural Products⊥

(2009) James B. McAlpine   JOURNAL OF NATURAL PRODUCTS

Rapid Cloning and Heterologous Expression of the Meridamycin Biosynthetic Gene Cluster Using a VersatileEscherichia coli−StreptomycesArtificial Chromosome Vector, pSBAC⊥

(2009) Hongbo Liu et al.   JOURNAL OF NATURAL PRODUCTS

Structures and Mechanisms of Polyketide Synthases

(2009) Chaitan Khosla   JOURNAL OF ORGANIC CHEMISTRY

Working outside the protein-synthesis rules: insights into non-ribosomal peptide synthesis

(2009) Mohamed A. Marahiel   JOURNAL OF PEPTIDE SCIENCE

Biochemical Analysis of the Biosynthetic Pathway of an Anticancer Tetracycline SF2575

(2009) Lauren B. Pickens et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of Salinosporamides from α,β-Unsaturated Fatty Acids: Implications for Extending Polyketide Synthase Diversity

(2009) Yuan Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Escherichia coliAllows Efficient Modular Incorporation of Newly Isolated Quinomycin Biosynthetic Enzyme into Echinomycin Biosynthetic Pathway for Rational Design and Synthesis of Potent Antibiotic Unnatural Natural Product

(2009) Kenji Watanabe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antitumor Compounds from Marine Actinomycetes

(2009) Carlos Olano et al.   Marine Drugs

Heterologous production of non-ribosomal peptide LLD-ACV in Saccharomyces cerevisiae

(2009) Verena Siewers et al.   METABOLIC ENGINEERING

Metabolic flux analysis and pharmaceutical production

(2009) Brett A. Boghigian et al.   METABOLIC ENGINEERING

Myxobacteria—‘microbial factories’ for the production of bioactive secondary metabolites

(2009) Silke C. Wenzel et al.   Molecular BioSystems

Genomic basis for natural product biosynthetic diversity in the actinomycetes

(2009) Markus Nett et al.   NATURAL PRODUCT REPORTS

New natural product biosynthetic chemistry discovered by genome mining

(2009) Christophe Corre et al.   NATURAL PRODUCT REPORTS

Structural insights into nonribosomal peptide enzymatic assembly lines

(2009) Alexander Koglin et al.   NATURAL PRODUCT REPORTS

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

(2009) A. S. Eustaquio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Complete Reconstitution of a Highly Reducing Iterative Polyketide Synthase

(2009) S. M. Ma et al.   SCIENCE

Engineered production of iso-migrastatin in heterologous Streptomyces hosts

(2008) Zhiyang Feng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Exploring the Biosynthesis of Natural Products and Their Inherent Suitability for the Rational Design of Desirable Compounds through Genetic Engineering

(2008) Kenji WATANABE   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Genetic engineering of filamentous fungi — Progress, obstacles and future trends

(2008) Vera Meyer   BIOTECHNOLOGY ADVANCES

Replicon-free and markerless methods for genomic insertion of DNAs in phage attachment sites and controlled expression of chromosomal genes inEscherichia coli

(2008) Chung-Jen Chiang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Heterologous expression of metK1-sp and afsR-sp in Streptomyces venezuelae for the production of pikromycin

(2008) Sushila Maharjan et al.   BIOTECHNOLOGY LETTERS

Metabolic engineering of noviose: heterologous expression of novWUS and generation of a new hybrid antibiotic, noviosylated 10-deoxymethynolide/narbonolide, from Streptomyces venezuelae YJ003-OTBP1

(2008) Binod Babu Pageni et al.   BIOTECHNOLOGY LETTERS

Current status, strategies, and potential for the metabolic engineering of heterologous polyketides in Escherichia coli

(2008) Brett A. Boghigian et al.   BIOTECHNOLOGY LETTERS

Authentic Heterologous Expression of the Tenellin Iterative Polyketide Synthase Nonribosomal Peptide Synthetase Requires Coexpression with an Enoyl Reductase

(2008) Laura M. Halo et al.   CHEMBIOCHEM

Protein–Protein Interactions in Multienzyme Megasynthetases

(2008) Kira J. Weissman et al.   CHEMBIOCHEM

A Type I/Type III Polyketide Synthase Hybrid Biosynthetic Pathway for the Structurally UniqueansaCompound Kendomycin

(2008) Silke C. Wenzel et al.   CHEMBIOCHEM

Investigations into Viomycin Biosynthesis by Using Heterologous Production inStreptomyces lividans

(2008) John J. Barkei et al.   CHEMBIOCHEM

Biosynthesis of the Cyclooligomer Depsipeptide Beauvericin, a Virulence Factor of the Entomopathogenic Fungus Beauveria bassiana

(2008) Yuquan Xu et al.   CHEMISTRY & BIOLOGY

Recent Advances in Artemisinin Production Through Heterologous Expression

(2008) Patrick Arsenault et al.   CURRENT MEDICINAL CHEMISTRY

Metabolic engineering for plant natural product biosynthesis in microbes

(2008) Joseph A Chemler et al.   CURRENT OPINION IN BIOTECHNOLOGY

Biosynthesis and Genetic Engineering of Lipopeptide Antibiotics Related to Daptomycin

(2008) Richard Baltz   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Biosynthesis of spectinomycin: heterologous production of spectinomycin and spectinamine in an aminoglycoside-deficient host,Streptomyces venezuelaeYJ003

(2008) L.P. Thapa et al.   JOURNAL OF APPLIED MICROBIOLOGY

Identification and Utility of FdmR1 as a Streptomyces Antibiotic Regulatory Protein Activator for Fredericamycin Production in Streptomyces griseus ATCC 49344 and Heterologous Hosts

(2008) Y. Chen et al.   JOURNAL OF BACTERIOLOGY

Advances in Recovery of Novel Biocatalysts from Metagenomes

(2008) Helen L. Steele et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production

(2008) Benedikt Engels et al.   METABOLIC ENGINEERING

Pharmaceutically Active Natural Product Synthesis and Supply via Plant Cell Culture Technology

(2008) Martin E. Kolewe et al.   MOLECULAR PHARMACEUTICS

Diversity of Polyketide Synthases Found in theAspergillusandStreptomycesGenomes

(2008) James F. Sanchez et al.   MOLECULAR PHARMACEUTICS

In Vivo and In Vitro Production Options for Fungal Secondary Metabolites

(2008) Patrick Schneider et al.   MOLECULAR PHARMACEUTICS

Nonribosomal Peptide Synthetases Involved in the Production of Medically Relevant Natural Products

(2008) Elizabeth A. Felnagle et al.   MOLECULAR PHARMACEUTICS

Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways

(2008) Elizabeth S. Sattely et al.   NATURAL PRODUCT REPORTS

Heterologous expression systems for polyketide synthases

(2008) Isao Fujii   NATURAL PRODUCT REPORTS

Efficient transfer of two large secondary metabolite pathway gene clusters into heterologous hosts by transposition

(2008) Jun Fu et al.   NUCLEIC ACIDS RESEARCH

Genetic dissection of the biosynthetic route to gentamicin A2 by heterologous expression of its minimal gene set

(2008) J. W. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli

(2008) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

6-Deoxyerythronolide B production through chromosomal localization of the deoxyerythronolide B synthase genes in E. coli

(2007) Yong Wang et al.   METABOLIC ENGINEERING