Cancer drug discovery: recent innovative approaches to tumor modeling

High-throughput screening approaches and combinatorial development of biomaterials using microfluidics

(2016) David Barata et al.   Acta Biomaterialia

High-throughput imaging: Focusing in on drug discovery in 3D

(2016) Linfeng Li et al.   METHODS

3D printed nanocomposite matrix for the study of breast cancer bone metastasis

(2016) Wei Zhu et al.   Nanomedicine-Nanotechnology Biology and Medicine

Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting

(2016) Xuanyi Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained

(2016) Michele Zanoni et al.   Scientific Reports

Drug Discovery Goes Three-Dimensional: Goodbye to Flat High-Throughput Screening?

(2015) Richard M. Eglen et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Three-Dimensional Cell Culture Assays: Are They More Predictive of In Vivo Efficacy than 2D Monolayer Cell-Based Assays?

(2015) Sitta Sittampalam et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

High-Content Assays for Characterizing the Viability and Morphology of 3D Cancer Spheroid Cultures

(2015) Oksana Sirenko et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Deconstructing the role of the ECM microenvironment on drug efficacy targeting MAPK signaling in a pre-clinical platform for cutaneous melanoma

(2015) Benjamin H. Blehm et al.   BIOMATERIALS

Multi-parametric hydrogels support 3D in vitro bioengineered microenvironment models of tumour angiogenesis

(2015) Laura J. Bray et al.   BIOMATERIALS

3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways

(2015) Peter DelNero et al.   BIOMATERIALS

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

3D Bioprinted Muscle and Tendon Tissues for Drug Development

(2015) Markus Rimann et al.   CHIMIA

Microfluidic 3D cell culture: from tools to tissue models

(2015) Vincent van Duinen et al.   CURRENT OPINION IN BIOTECHNOLOGY

High-throughput fluorescence imaging approaches for drug discovery usingin vitroandin vivothree-dimensional models

(2015) Natalia J Martinez et al.   Expert Opinion on Drug Discovery

3D matrix-based cell cultures: Automated analysis of tumor cell survival and proliferation

(2015) IRIS EKE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

In vitro co-culture model of medulloblastoma and human neural stem cells for drug delivery assessment

(2015) Delyan P. Ivanov et al.   JOURNAL OF BIOTECHNOLOGY

Evaluation of chemotherapeutics in a three-dimensional breast cancer model

(2015) Carrie J. Lovitt et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Bone marrow stroma-derived PGE2 protects BCP-ALL cells from DNA damage-induced p53 accumulation and cell death

(2015) Elin Naderi et al.   Molecular Cancer

Beyond 3D culture models of cancer

(2015) Kandice Tanner et al.   Science Translational Medicine

Bioprinting for cancer research

(2015) Stephanie Knowlton et al.   TRENDS IN BIOTECHNOLOGY

Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy

(2015) Hilary A. Kenny et al.   Nature Communications

Toward the Broad Adoption of 3D Tumor Models in the Cancer Drug Pipeline

(2015) Megan C. Cox et al.   ACS Biomaterials-Science & Engineering

Toward the Broad Adoption of 3D Tumor Models in the Cancer Drug Pipeline

(2015) Megan C. Cox et al.   ACS Biomaterials Science & Engineering

Feasibility of Primary Tumor Culture Models and Preclinical Prediction Assays for Head and Neck Cancer: A Narrative Review

(2015) Amy Dohmen et al.   Cancers

Peptide Hydrogels – Versatile Matrices for 3D Cell Culture in Cancer Medicine

(2015) Peter Worthington et al.   Frontiers in Oncology

Engineering an in vitro air-blood barrier by 3D bioprinting

(2015) Lenke Horváth et al.   Scientific Reports

3D cell culture systems modeling tumor growth determinants in cancer target discovery

(2014) Claudio R. Thoma et al.   ADVANCED DRUG DELIVERY REVIEWS

Engineered microenvironments provide new insights into ovarian and prostate cancer progression and drug responses

(2014) Daniela Loessner et al.   ADVANCED DRUG DELIVERY REVIEWS

Consideration of the cellular microenvironment: Physiologically relevant co-culture systems in drug discovery

(2014) Ellen L. Berg et al.   ADVANCED DRUG DELIVERY REVIEWS

How multi-organ microdevices can help foster drug development

(2014) Mandy B. Esch et al.   ADVANCED DRUG DELIVERY REVIEWS

3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs

(2014) David B. Kolesky et al.   ADVANCED MATERIALS

Bioengineered human tumor within a bone niche

(2014) Aranzazu Villasante et al.   BIOMATERIALS

Enhanced enrichment of prostate cancer stem-like cells with miniaturized 3D culture in liquid core-hydrogel shell microcapsules

(2014) Wei Rao et al.   BIOMATERIALS

A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone

(2014) Simone Bersini et al.   BIOMATERIALS

Three-dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo

(2014) John A. Hickman et al.   Biotechnology Journal

Cancer Cell Lines for Drug Discovery and Development

(2014) J. L. Wilding et al.   CANCER RESEARCH

Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment

(2014) D. Herrmann et al.   CARCINOGENESIS

An in vitro osteosarcoma 3D microtissue model for drug development

(2014) Markus Rimann et al.   JOURNAL OF BIOTECHNOLOGY

3D bioprinting of tissues and organs

(2014) Sean V Murphy et al.   NATURE BIOTECHNOLOGY

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Three-Dimensional Lung Tumor Microenvironment Modulates Therapeutic Compound Responsiveness In Vitro – Implication for Drug Development

(2014) Jason E. Ekert et al.   PLoS One

Quantification of Dynamic Morphological Drug Responses in 3D Organotypic Cell Cultures by Automated Image Analysis

(2014) Ville Härmä et al.   PLoS One

3-Dimensional Culture Systems for Anti-Cancer Compound Profiling and High-Throughput Screening Reveal Increases in EGFR Inhibitor-Mediated Cytotoxicity Compared to Monolayer Culture Systems

(2014) Amy L. Howes et al.   PLoS One

Ultra High Content Image Analysis and Phenotype Profiling of 3D Cultured Micro-Tissues

(2014) Zi Di et al.   PLoS One

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cavity-free plasmonic nanolasing enabled by dispersionless stopped light

(2014) Tim Pickering et al.   Nature Communications

An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models

(2014) Jonathan P. Celli et al.   Scientific Reports

In vitro clinical trials: the future of cell-based profiling

(2014) Nathan T. Ross et al.   Frontiers in Pharmacology

Miniaturized Three-Dimensional Cancer Model for Drug Evaluation

(2013) Carrie J. Lovitt et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer

(2013) Zhiyun Xu et al.   BIOMATERIALS

A Novel Model of Dormancy for Bone Metastatic Breast Cancer Cells

(2013) R. Marlow et al.   CANCER RESEARCH

3Din vitrotissue models and their potential for drug screening

(2013) Lauren Kimlin et al.   Expert Opinion on Drug Discovery

The Clinical Relevance of Cancer Cell Lines

(2013) J.-P. Gillet et al.   JNCI-Journal of the National Cancer Institute

Bone-stromal cells up-regulate tumourigenic markers in a tumour-stromal 3D model of prostate cancer

(2013) Louisa CE Windus et al.   Molecular Cancer

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

Ex vivo culture of human prostate tissue and drug development

(2013) Margaret M. Centenera et al.   Nature Reviews Urology

Technologies for deriving primary tumor cells for use in personalized cancer therapy

(2013) Abhisek Mitra et al.   TRENDS IN BIOTECHNOLOGY

Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

(2012) Maria Vinci et al.   BMC BIOLOGY

Inhibition of PI3K/mTOR Leads to Adaptive Resistance in Matrix-Attached Cancer Cells

(2012) Taru Muranen et al.   CANCER CELL

EGFR/JIP-4/JNK2 Signaling Attenuates Cetuximab-Mediated Radiosensitization of Squamous Cell Carcinoma Cells

(2012) I. Eke et al.   CANCER RESEARCH

In vivo biomarker expression patterns are preserved in 3D cultures of Prostate Cancer

(2012) Louisa C.E. Windus et al.   EXPERIMENTAL CELL RESEARCH

Discovery of small molecule cancer drugs: Successes, challenges and opportunities

(2012) Swen Hoelder et al.   Molecular Oncology

Systematic identification of genomic markers of drug sensitivity in cancer cells

(2012) Mathew J. Garnett et al.   NATURE

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Revisiting lab-on-a-chip technology for drug discovery

(2012) Pavel Neužil et al.   NATURE REVIEWS DRUG DISCOVERY

Three-dimensional cancer-bone metastasis model using ex-vivo co-cultures of live calvarial bones and cancer cells

(2011) Paul Curtin et al.   BIOMATERIALS

A three-dimensional in vitro ovarian cancer coculture model using a high-throughput cell patterning platform

(2011) Feng Xu et al.   Biotechnology Journal

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Advances in the preclinical testing of cancer therapeutic hypotheses

(2011) Giordano Caponigro et al.   NATURE REVIEWS DRUG DISCOVERY

Impact of high-throughput screening in biomedical research

(2011) Ricardo Macarron et al.   NATURE REVIEWS DRUG DISCOVERY

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array

(2010) Yi-Chung Tung et al.   ANALYST

Activity of Anticancer Agents in a Three-Dimensional Cell Culture Model

(2010) Victor Sanjit Nirmalanandhan et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells

(2010) Daniela Loessner et al.   BIOMATERIALS

A Comprehensive Panel of Three-Dimensional Models for Studies of Prostate Cancer Growth, Invasion and Drug Responses

(2010) Ville Härmä et al.   PLoS One

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Three-Dimensional Fiber Deposition of Cell-Laden, Viable, Patterned Constructs for Bone Tissue Printing

(2008) Natalja E. Fedorovich et al.   TISSUE ENGINEERING PART A