A diversity oriented synthesis of natural product inspired molecular libraries

Synthesis of 3-acylindoles by oxidative rearrangement of 2-aminochalcones using a hypervalent iodine reagent and cyclization sequence

(2017) Akira Nakamura et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Scaffold Diversity Synthesis and Its Application in Probe and Drug Discovery

(2016) Miguel Garcia-Castro et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Counting on natural products for drug design

(2016) Tiago Rodrigues et al.   Nature Chemistry

Natural product inspired design and synthesis of β-carboline and γ-lactone based molecular hybrids

(2016) Dharmender Singh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Stereoselective synthesis of a natural product inspired tetrahydroindolo[2,3-a]-quinolizine compound library

(2015) Muthukumar G. Sankar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Intuitive Ordering of Scaffolds and Scaffold Similarity Searching Using Scaffold Keys

(2014) Peter Ertl   Journal of Chemical Information and Modeling

Efficient discovery of bioactive scaffolds by activity-directed synthesis

(2014) George Karageorgis et al.   Nature Chemistry

Syntheses of a library of molecules on the marine natural product ianthelliformisamines platform and their biological evaluation

(2014) Faiz Ahmed Khan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Diversity-oriented synthesis as a tool for identifying new modulators of mitosis

(2014) Brett M. Ibbeson et al.   Nature Communications

Natural products as lead structures: chemical transformations to create lead-like libraries

(2013) Mauro Pascolutti et al.   DRUG DISCOVERY TODAY

Use of Natural Products as Chemical Library for Drug Discovery and Network Pharmacology

(2013) Jiangyong Gu et al.   PLoS One

2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products

(2012) Alan D. Borthwick   CHEMICAL REVIEWS

Diversity-oriented synthesis: producing chemical tools for dissecting biology

(2012) Cornelius J. O' Connor et al.   CHEMICAL SOCIETY REVIEWS

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Facile Oxidative Rearrangements Using Hypervalent Iodine Reagents

(2012) Fateh V. Singh et al.   ChemistryOpen

Natural product-like synthetic libraries

(2011) Gemma L Thomas et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Natural products: An evolving role in future drug discovery

(2011) Bhuwan B. Mishra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Modulating Protein–Protein Interactions with Small Molecules: The Importance of Binding Hotspots

(2011) Ratna Rajesh Thangudu et al.   JOURNAL OF MOLECULAR BIOLOGY

Synthesis of natural-product-like scaffolds in unprecedented efficiency via a 12-fold branching pathway

(2011) Diane Robbins et al.   Chemical Science

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

(2010) Warren R.J.D. Galloway et al.   Nature Communications

Designing Focused Chemical Libraries Enriched in Protein-Protein Interaction Inhibitors using Machine-Learning Methods

(2010) Christelle Reynès et al.   PLoS Computational Biology

Modeling Effects of Human Single Nucleotide Polymorphisms on Protein-Protein Interactions

(2009) Shaolei Teng et al.   BIOPHYSICAL JOURNAL

The influence of lead discovery strategies on the properties of drug candidates

(2009) György M. Keserü et al.   NATURE REVIEWS DRUG DISCOVERY

Drug-Like Inhibitors of Protein-Protein Interactions: A Structural Examination of Effective Protein Mimicry

(2008) D. Fry   CURRENT PROTEIN & PEPTIDE SCIENCE

Natural products in drug discovery

(2008) A HARVEY   DRUG DISCOVERY TODAY

Marine Natural Product Libraries for High-Throughput Screening and Rapid Drug Discovery

(2008) Tim S. Bugni et al.   JOURNAL OF NATURAL PRODUCTS

Oxidative Rearrangement of Tertiary Allylic Alcohols Employing Oxoammonium Salts

(2008) Masatoshi Shibuya et al.   JOURNAL OF ORGANIC CHEMISTRY

Protein interactions in human genetic diseases

(2008) Benjamin Schuster-Böckler et al.   GENOME BIOLOGY

Towards the Optimal Screening Collection: A Synthesis Strategy

(2007) Thomas E. Nielsen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION