Automated Imaging and other developments in whole-organism anthelmintic screening

Quantitative Screening for Anticestode Drugs Based on Changes in Baseline Enzyme Secretion by Taenia crassiceps

(2012) S. Mahanty et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis

(2012) Hyokyeong Lee et al.   BMC GENOMICS

Isothermal microcalorimetry to study the activity of triclabendazole and its metabolites on juvenile and adult Fasciola hepatica

(2012) Jennifer Keiser et al.   EXPERIMENTAL PARASITOLOGY

Electrical sorting of Caenorhabditis elegans

(2012) Pouya Rezai et al.   LAB ON A CHIP

A sorting strategy for C. elegans based on size-dependent motility and electrotaxis in a micro-structured channel

(2012) Bicheng Han et al.   LAB ON A CHIP

Development of an in vitro drug screening assay using Schistosoma haematobium schistosomula

(2012) Monika Marxer et al.   Parasites & Vectors

Comparison of novel and existing tools for studying drug sensitivity against the hookworm Ancylostoma ceylanicum in vitro

(2012) LUCIENNE TRITTEN et al.   PARASITOLOGY

WormScan: A Technique for High-Throughput Phenotypic Analysis of Caenorhabditis elegans

(2012) Mark D. Mathew et al.   PLoS One

Confocal Laser Scanning Microscopy, a New In Vivo Diagnostic Tool for Schistosomiasis

(2012) Carlos Fritzsche et al.   PLoS One

The global burden of neglected tropical diseases

(2012) A. Fenwick   PUBLIC HEALTH

A new approach for anthelmintic discovery for humans

(2012) Timothy G. Geary et al.   TRENDS IN PARASITOLOGY

Efficacy and Safety of Nitazoxanide, Albendazole, and Nitazoxanide-Albendazole against Trichuris trichiura Infection: A Randomized Controlled Trial

(2012) Benjamin Speich et al.   PLoS Neglected Tropical Diseases

Whole Organism High-Content Screening by Label-Free, Image-Based Bayesian Classification for Parasitic Diseases

(2012) Ross A. Paveley et al.   PLoS Neglected Tropical Diseases

A Research Agenda for Helminth Diseases of Humans: The Problem of Helminthiases

(2012) Sara Lustigman et al.   PLoS Neglected Tropical Diseases

WormAssay: A Novel Computer Application for Whole-Plate Motion-based Screening of Macroscopic Parasites

(2012) Chris Marcellino et al.   PLoS Neglected Tropical Diseases

Activity of OZ78 analogues against Fasciola hepatica and Echinostoma caproni

(2011) Carla Kirchhofer et al.   ACTA TROPICA

Cross-disciplinary approaches for measuring parasitic helminth viability and phenotype

(2011) Emily Peak et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

Technologies for Micromanipulating, Imaging, and Phenotyping Small Invertebrates and Vertebrates

(2011) Mehmet Fatih Yanik et al.   Annual Review of Biomedical Engineering

Hormone Signaling and Phenotypic Plasticity in Nematode Development and Evolution

(2011) Ralf J. Sommer et al.   CURRENT BIOLOGY

Wormometry-on-a-chip: Innovative technologies for in situ analysis of small multicellular organisms

(2011) Donald Wlodkowic et al.   CYTOMETRY PART A

Isothermal Microcalorimetry To Study Drugs against Schistosoma mansoni

(2011) T. Manneck et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Exploration of novel in vitro assays to study drugs against Trichuris spp.

(2011) Angelika Silbereisen et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Development of Taenia pisiformis in golden hamster (Mesocricetus auratus)

(2011) Elizabeth Toral-Bastida et al.   Parasites & Vectors

Nucleic acid transfection and transgenesis in parasitic nematodes

(2011) JAMES B. LOK   PARASITOLOGY

Efficacy of the cyclooctadepsipeptide PF1022A against Heligmosomoides bakeri in vitro and in vivo

(2011) UZOMA NWOSU et al.   PARASITOLOGY

Paving the way for transgenic schistosomes

(2011) S. BECKMANN et al.   PARASITOLOGY

Confocal Laser Scanning Microscopy for Detection of Schistosoma mansoni Eggs in the Gut of Mice

(2011) Martha Charlotte Holtfreter et al.   PLoS One

Target-based and whole-worm screening approaches to anthelmintic discovery

(2011) A.C. Kotze   VETERINARY PARASITOLOGY

A Screen against Leishmania Intracellular Amastigotes: Comparison to a Promastigote Screen and Identification of a Host Cell-Specific Hit

(2011) Geraldine De Muylder et al.   PLoS Neglected Tropical Diseases

Luciferase-Expressing Leishmania infantum Allows the Monitoring of Amastigote Population Size, In Vivo, Ex Vivo and In Vitro

(2011) Grégory Michel et al.   PLoS Neglected Tropical Diseases

Tracing of the Bile-Chemotactic Migration of Juvenile Clonorchis sinensis in Rabbits by PET-CT

(2011) Tae Im Kim et al.   PLoS Neglected Tropical Diseases

Schistosoma mansoni: Antischistosomal activity of the four optical isomers and the two racemates of mefloquine on schistosomula and adult worms in vitro and in vivo

(2010) Theresia Manneck et al.   EXPERIMENTAL PARASITOLOGY

Estimating the global distribution and disease burden of intestinal nematode infections: Adding up the numbers – A review

(2010) Simon Brooker   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Activity of novel nicotinic anthelmintics in cut preparations of Caenorhabditis elegans

(2010) Elizabeth Ruiz-Lancheros et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Efficacy and safety of mefloquine, artesunate, mefloquine–artesunate, tribendimidine, and praziquantel in patients with Opisthorchis viverrini: a randomised, exploratory, open-label, phase 2 trial

(2010) Phonepasong Soukhathammavong et al.   LANCET INFECTIOUS DISEASES

Development of fluorescent Plasmodium falciparum for in vitro growth inhibition assays

(2010) Danny W Wilson et al.   MALARIA JOURNAL

Know your chemical space

(2010) Andrew L Hopkins et al.   Nature Chemical Biology

A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans

(2010) Andrew R Burns et al.   Nature Chemical Biology

Imaging of Toxocara canis larvae labelled by CFSE in BALB/c mice

(2010) Petra Kolbeková et al.   PARASITOLOGY RESEARCH

Anthelmintic activity of KSI-4088 against Caenorhabditis elegans

(2010) Kusuma Kaewintajuk et al.   PARASITOLOGY RESEARCH

Automated High-Content Live Animal Drug Screening Using C. elegans Expressing the Aggregation Prone Serpin α1-antitrypsin Z

(2010) Sager J. Gosai et al.   PLoS One

Helminthic Diseases in the Abdomen: An Epidemiologic and Radiologic Overview

(2010) Cinthia D. Ortega et al.   RADIOGRAPHICS

In Vivo Imaging of Schistosomes to Assess Disease Burden Using Positron Emission Tomography (PET)

(2010) Nicolas Salem et al.   PLoS Neglected Tropical Diseases

Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach

(2010) Gregory J. Crowther et al.   PLoS Neglected Tropical Diseases

Development and Validation of a Quantitative, High-Throughput, Fluorescent-Based Bioassay to Detect Schistosoma Viability

(2010) Emily Peak et al.   PLoS Neglected Tropical Diseases

Comparison of Microscopy and Alamar Blue Reduction in a Larval Based Assay for Schistosome Drug Screening

(2010) Nuha R. Mansour et al.   PLoS Neglected Tropical Diseases

A Novel High Throughput Assay for Anthelmintic Drug Screening and Resistance Diagnosis by Real-Time Monitoring of Parasite Motility

(2010) Michael J. Smout et al.   PLoS Neglected Tropical Diseases

High-Throughput Screen for Novel Antimicrobials using a Whole Animal Infection Model

(2009) Terence I. Moy et al.   ACS Chemical Biology

Schistosomes—proteomics studies for potential novel vaccines and drug targets

(2009) Ricardo DeMarco et al.   DRUG DISCOVERY TODAY

Imaging schistosomes in vivo

(2009) Greice Krautz-Peterson et al.   FASEB JOURNAL

Unresolved issues in anthelmintic pharmacology for helminthiases of humans

(2009) Timothy G. Geary et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Echinococcus metacestodes as laboratory models for the screening of drugs against cestodes and trematodes

(2009) A. HEMPHILL et al.   PARASITOLOGY

Visualisation and Quantitative Analysis of the Rodent Malaria Liver Stage by Real Time Imaging

(2009) Ivo H. J. Ploemen et al.   PLoS One

Fluorescent Imaging of Antigen Released by a Skin-Invading Helminth Reveals Differential Uptake and Activation Profiles by Antigen Presenting Cells

(2009) Ross A. Paveley et al.   PLoS Neglected Tropical Diseases

Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening

(2009) Maha-Hamadien Abdulla et al.   PLoS Neglected Tropical Diseases

Bioluminescent Imaging of Trypanosoma brucei Shows Preferential Testis Dissemination Which May Hamper Drug Efficacy in Sleeping Sickness

(2009) Filip Claes et al.   PLoS Neglected Tropical Diseases

Anti-schistosomal Intervention Targets Identified by Lifecycle Transcriptomic Analyses

(2009) Jennifer M. Fitzpatrick et al.   PLoS Neglected Tropical Diseases

Bioluminescent imaging of Trypanosoma cruzi infection

(2008) Kenneth V. Hyland et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Efficacy of Current Drugs Against Soil-Transmitted Helminth Infections

(2008) Jennifer Keiser et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Helminth infections: the great neglected tropical diseases

(2008) Peter J. Hotez et al.   JOURNAL OF CLINICAL INVESTIGATION

Sub-cellular precision on-chip small-animal immobilization, multi-photon imaging and femtosecond-laser manipulation

(2008) Fei Zeng et al.   LAB ON A CHIP

CO2and compressive immobilization of C. elegans on-chip

(2008) Trushal Vijaykumar Chokshi et al.   LAB ON A CHIP

Identification of oxadiazoles as new drug leads for the control of schistosomiasis

(2008) Ahmed A Sayed et al.   NATURE MEDICINE

Automated on-chip rapid microscopy, phenotyping and sorting of C. elegans

(2008) Kwanghun Chung et al.   NATURE METHODS

Genomic-scale prioritization of drug targets: the TDR Targets database

(2008) Fernán Agüero et al.   NATURE REVIEWS DRUG DISCOVERY

In vitro schistosomicidal activity of curcumin against Schistosoma mansoni adult worms

(2008) Lizandra G. Magalhães et al.   PARASITOLOGY RESEARCH

The Parallel Worm Tracker: A Platform for Measuring Average Speed and Drug-Induced Paralysis in Nematodes

(2008) Daniel Ramot et al.   PLoS One

Application of in vitro anthelmintic sensitivity assays to canine parasitology: Detecting resistance to pyrantel in Ancylostoma caninum

(2008) Steven R. Kopp et al.   VETERINARY PARASITOLOGY

Dimensionality and Dynamics in the Behavior of C. elegans

(2008) Greg J. Stephens et al.   PLoS Computational Biology

Tribendimidine and Albendazole for Treating Soil-Transmitted Helminths, Strongyloides stercoralis and Taenia spp.: Open-Label Randomized Trial

(2008) Peter Steinmann et al.   PLoS Neglected Tropical Diseases

Microscopic imaging techniques for drug discovery

(2007) Andrew Bullen   NATURE REVIEWS DRUG DISCOVERY