Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice

Juglanin ameliorates LPS-induced neuroinflammation in animal models of Parkinson’s disease and cell culture via inactivating TLR4/NF-κB pathway

(2018) Fang-Xue Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Design, synthesis and biological evaluation of 7 H -pyrrolo[2,3- d ]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis

(2018) Linhong He et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Urolithins Attenuate LPS-Induced Neuroinflammation in BV2Microglia via MAPK, Akt, and NF-κB Signaling Pathways

(2018) Jialin Xu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The role of glucocorticoid, interleukin-1β, and antioxidants in prenatal stress effects on embryonic microglia

(2018) Jada Bittle et al.   Journal of Neuroinflammation

Ibrutinib inhibits free fatty acid metabolism in chronic lymphocytic leukemia

(2018) Uri Rozovski et al.   LEUKEMIA & LYMPHOMA

Prior exposure to corticosterone markedly enhances and prolongs the neuroinflammatory response to systemic challenge with LPS

(2018) Kimberly A. Kelly et al.   PLoS One

Gypenoside IX Suppresses p38 MAPK/Akt/NFκB Signaling Pathway Activation and Inflammatory Responses in Astrocytes Stimulated by Proinflammatory Mediators

(2017) Xiaoshuang Wang et al.   INFLAMMATION

Toll-Like Receptor-4 Inhibitor TAK-242 Attenuates Motor Dysfunction and Spinal Cord Pathology in an Amyotrophic Lateral Sclerosis Mouse Model

(2017) Avi Fellner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Mercaptoacetamide-Based Class II Histone Deacetylase Inhibitor Suppresses Cell Migration and Invasion in Monomorphic Malignant Human Glioma Cells by Inhibiting FAK/STAT3 Signaling

(2017) Jin Han Nam et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Neuroinflammatory responses in Alzheimer’s disease

(2017) Cira Dansokho et al.   JOURNAL OF NEURAL TRANSMISSION

Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity

(2017) Kelly S. Kirkley et al.   Journal of Neuroinflammation

Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo

(2017) Nicholas C. Woodward et al.   Journal of Neuroinflammation

Ibrutinib modulates the immunosuppressive CLL microenvironment through STAT3-mediated suppression of regulatory B-cell function and inhibition of the PD-1/PD-L1 pathway

(2017) K Kondo et al.   LEUKEMIA

Deep hypothermia therapy attenuates LPS-induced microglia neuroinflammation via the STAT3 pathway

(2017) G. Tong et al.   NEUROSCIENCE

The Bruton’s tyrosine kinase inhibitor ibrutinib exerts immunomodulatory effects through regulation of tumor-infiltrating macrophages

(2017) Lingyan Ping et al.   Oncotarget

Pinus densiflora needle supercritical fluid extract suppresses the expression of pro-inflammatory mediators iNOS, IL-6 and IL-1β, and activation of inflammatory STAT1 and STAT3 signaling proteins in bacterial lipopolysaccharide-challenged murine macrophages

(2017) Thamizhiniyan Venkatesan et al.   DARU-Journal of Pharmaceutical Sciences

Micheliolide suppresses LPS-induced neuroinflammatory responses

(2017) Zhaomeng Sun et al.   PLoS One

Ibrutinib penetrates the blood brain barrier and shows efficacy in the therapy of Bing Neel syndrome

(2016) Christopher Mason et al.   BRITISH JOURNAL OF HAEMATOLOGY

Anti-Neuroinflammatory Effects of Fucoxanthin via Inhibition of Akt/NF-κB and MAPKs/AP-1 Pathways and Activation of PKA/CREB Pathway in Lipopolysaccharide-Activated BV-2 Microglial Cells

(2016) Dong Zhao et al.   NEUROCHEMICAL RESEARCH

Alterations in microglial phenotype and hippocampal neuronal function in transgenic mice with astrocyte-targeted production of interleukin-10

(2015) Beatriz Almolda et al.   BRAIN BEHAVIOR AND IMMUNITY

Pinocembrin inhibits lipopolysaccharide-induced inflammatory mediators production in BV2 microglial cells through suppression of PI3K/Akt/NF-κB pathway

(2015) Lu-ting Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Phlorofucofuroeckol B suppresses inflammatory responses by down-regulating nuclear factor κB activation via Akt, ERK, and JNK in LPS-stimulated microglial cells

(2015) Dong-Kyung Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Systemic inflammation and microglial activation: systematic review of animal experiments

(2015) Inge C.M. Hoogland et al.   Journal of Neuroinflammation

Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways

(2015) Junghyung Park et al.   NEUROSCIENCE LETTERS

Neuroinflammation: Ways in Which the Immune System Affects the Brain

(2015) Richard M. Ransohoff et al.   Neurotherapeutics

Regulation of microglial migration, phagocytosis, and neurite outgrowth by HO-1/CO signaling

(2014) Hannah Scheiblich et al.   Developmental Neurobiology

Tauroursodeoxycholic acid reduces glial cell activation in an animal model of acute neuroinflammation

(2014) Natalia Yanguas-Casás et al.   Journal of Neuroinflammation

Early Activation of STAT3 Regulates Reactive Astrogliosis Induced by Diverse Forms of Neurotoxicity

(2014) James P. O'Callaghan et al.   PLoS One

The orally available Btk inhibitor ibrutinib (PCI-32765) protects against osteoclast-mediated bone loss

(2013) Masahiro Shinohara et al.   BONE

Neuronal activity-dependent STAT3 localization to nucleus is dependent on Tyr-705 and Ser-727 phosphorylation in rat hippocampal neurons

(2013) Sachiko Murase et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Toll-Like Receptors in Antiviral Innate Immunity

(2013) Sandra N. Lester et al.   JOURNAL OF MOLECULAR BIOLOGY

The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia

(2013) Piotr Przanowski et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Prevention of LPS-Induced Microglia Activation, Cytokine Production and Sickness Behavior with TLR4 Receptor Interfering Peptides

(2013) Dustin J. Hines et al.   PLoS One

A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1Β, TNF-α and IL-6 Challenges in C57BL/6 Mice

(2013) Donal T. Skelly et al.   PLoS One

A new synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), suppresses the Toll-like receptor 4-mediated inflammatory response through inhibition of the Akt/NF-κB pathway in BV2 microglial cells

(2012) Young Han Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Caffeine suppresses lipopolysaccharide-stimulated BV2 microglial cells by suppressing Akt-mediated NF-κB activation and ERK phosphorylation

(2012) Chang-Hee Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

The PI3K/Akt pathway is required for LPS activation of microglial cells

(2012) Concetta Saponaro et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Artemisinin Attenuates Lipopolysaccharide-Stimulated Proinflammatory Responses by Inhibiting NF-κB Pathway in Microglia Cells

(2012) Cansheng Zhu et al.   PLoS One

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

(2011) Mark L. Hanke et al.   CLINICAL SCIENCE

Role of microglia in CNS inflammation

(2011) Manuel B. Graeber et al.   FEBS LETTERS

Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behavior

(2011) Michael D Burton et al.   Journal of Neuroinflammation

Phospholipase D2 acts as an important regulator in LPS-induced nitric oxide synthesis in Raw 264.7 cells

(2009) Shin-Young Park et al.   CELLULAR SIGNALLING

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN