A new synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), suppresses the Toll-like receptor 4-mediated inflammatory response through inhibition of the Akt/NF-κB pathway in BV2 microglial cells

Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities

(2011) Soon Young Shin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

(2011) Mark L. Hanke et al.   CLINICAL SCIENCE

The Yin and Yang of Microglia

(2011) Melinda Czeh et al.   DEVELOPMENTAL NEUROSCIENCE

Anti-inflammatory effects of fucoidan through inhibition of NF-κB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells

(2011) Hye Young Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Dietary chalcones with chemopreventive and chemotherapeutic potential

(2011) Barbora Orlikova et al.   Genes and Nutrition

3′-Chloro-5,7-dimethoxyisoflavone inhibits TNFα-induced CXCL10 gene transcription by suppressing the NF-κB pathway in HCT116 human colon cancer cells

(2011) Soon Young Shin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells

(2010) Hui Jing et al.   CANCER LETTERS

Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra

(2010) Hey-Kyeong Jeong et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

The role of chalcones in suppression of NF-κB-mediated inflammation and cancer

(2010) Vivek R. Yadav et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Microglia: biology and pathology

(2009) Manuel B. Graeber et al.   ACTA NEUROPATHOLOGICA

TLRs and chronic inflammation

(2009) Caroline Ospelt et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Shikonins attenuate microglial inflammatory responses by inhibition of ERK, Akt, and NF-κB: neuroprotective implications

(2008) Kyong Nyon Nam et al.   NEUROPHARMACOLOGY