Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy

The Long Isoform of Cellular FLIP Is Essential for T Lymphocyte Proliferation through an NF- B-Independent Pathway

(2014) N. Zhang et al.   JOURNAL OF IMMUNOLOGY

F-box protein 10, an NF-κB-dependent anti-apoptotic protein, regulates TRAIL-induced apoptosis through modulating c-Fos/c-FLIP pathway

(2011) R Ge et al.   CELL DEATH AND DIFFERENTIATION

Paxilline enhances TRAIL-mediated apoptosis of glioma cellsviamodulation of c-FLIP, survivin and DR5

(2011) You Jung Kang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

β-Elemene Piperazine Derivatives Induce Apoptosis in Human Leukemia Cells through Downregulation of c-FLIP and Generation of ROS

(2011) Zhiying Yu et al.   PLoS One

Epithelial-to-Mesenchymal Transition in Pancreatic Adenocarcinoma

(2011) Carla Cano et al.   TheScientificWorldJOURNAL

LY294002 potentiates the anti-cancer effect of oxaliplatin for gastric cancerviadeath receptor pathway

(2011) Jie Liu   WORLD JOURNAL OF GASTROENTEROLOGY

Triggering of death receptor apoptotic signaling by human papillomavirus 16 E2 protein in cervical cancer cell lines is mediated by interaction with c-FLIP

(2010) Wei Wang et al.   APOPTOSIS

In vitro and in vivo characterisation of a novel c-FLIP-targeted antisense phosphorothioate oligonucleotide

(2010) Andrew E. Logan et al.   APOPTOSIS

Sorafenib inhibits ERK1/2 and MCL-1L phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma

(2010) Sharyn I. Katz et al.   CANCER BIOLOGY & THERAPY

Synergistic Effect of Celecoxib on TRAIL-induced Apoptosis in Hepatocellular Carcinoma Cells

(2010) Guoyue Lu et al.   CANCER INVESTIGATION

Synergistic antitumor effect of TRAIL in combination with sunitinib in vitro and in vivo

(2010) Wanjing Ding et al.   CANCER LETTERS

Chrysin sensitizes tumor necrosis factor-α-induced apoptosis in human tumor cells via suppression of nuclear factor-kappaB

(2010) Xin Li et al.   CANCER LETTERS

Proteasome inhibition: A new therapeutic strategy to cancer treatment

(2010) William Ka Kei Wu et al.   CANCER LETTERS

Targeting c-FLIP in cancer

(2010) Sarah Shirley et al.   CANCER LETTERS

Ubiquitin-Specific Protease 8 Links the PTEN-Akt-AIP4 Pathway to the Control of FLIPSStability and TRAIL Sensitivity in Glioblastoma Multiforme

(2010) Amith Panner et al.   CANCER RESEARCH

ATM kinase activity modulates cFLIP protein levels: potential interplay between DNA damage signalling and TRAIL-induced apoptosis

(2010) Venturina Stagni et al.   CARCINOGENESIS

c-FLIPL enhances anti-apoptotic Akt functions by modulation of Gsk3β activity

(2010) C Quintavalle et al.   CELL DEATH AND DIFFERENTIATION

Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell leukemia/lymphoma by translational suppression of c-FLIP expression

(2010) M Bleumink et al.   CELL DEATH AND DIFFERENTIATION

Prognostic Significance of TRAIL Signaling Molecules in Stage II and III Colorectal Cancer

(2010) D. P. McLornan et al.   CLINICAL CANCER RESEARCH

Proapoptotic DR4 and DR5 signaling in cancer cells: toward clinical translation

(2010) Annie Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Compound C sensitizes Caki renal cancer cells to TRAIL-induced apoptosis through reactive oxygen species-mediated down-regulation of c-FLIPL and Mcl-1

(2010) Ji Hoon Jang et al.   EXPERIMENTAL CELL RESEARCH

Identification of c-FLIPL and c-FLIPS as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells

(2010) C. Haag et al.   GUT

The role of c-FLIPL in ovarian cancer: Chaperoning tumor cells from immunosurveillance and increasing their invasive potential

(2010) Ahmed El-Gazzar et al.   GYNECOLOGIC ONCOLOGY

Insights on distinct pathways of thiazolidinediones (PPARγ ligand)-promoted apoptosis in TRAIL-sensitive or -resistant malignant urothelial cells

(2010) Marie Laure Plissonnier et al.   INTERNATIONAL JOURNAL OF CANCER

Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins

(2010) Lee   INTERNATIONAL JOURNAL OF ONCOLOGY

Itch/AIP4-independent proteasomal degradation of cFLIP induced by the histone deacetylase inhibitor SAHA sensitizes breast tumour cells to TRAIL

(2010) Rosario Yerbes et al.   INVESTIGATIONAL NEW DRUGS

Inhibition of NF-κB Signaling by Quinacrine Is Cytotoxic to Human Colon Carcinoma Cell Lines and Is Synergistic in Combination with Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) or Oxaliplatin

(2010) Tanvi S. Jani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase I Dose-Escalation Study of Recombinant Human Apo2L/TRAIL, a Dual Proapoptotic Receptor Agonist, in Patients With Advanced Cancer

(2010) Roy S. Herbst et al.   JOURNAL OF CLINICAL ONCOLOGY

Beneficial health effects of lupeol triterpene: A review of preclinical studies

(2010) Hifzur Rahman Siddique et al.   LIFE SCIENCES

4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells

(2010) Khadijeh Bijangi-Vishehsaraei et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition

(2010) Nicolas Charette et al.   Molecular Cancer

TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs/Akt/GSK-3β pathway and activation of caspases

(2010) Suk-Bin Seo et al.   Molecular Cancer

Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics

(2010) Camilla Krakstad et al.   Molecular Cancer

Selective Inhibition of Histone Deacetylases Sensitizes Malignant Cells to Death Receptor Ligands

(2010) T. E. Wood et al.   MOLECULAR CANCER THERAPEUTICS

Bortezomib Sensitizes Human Esophageal Squamous Cell Carcinoma Cells to TRAIL-Mediated Apoptosis via Activation of Both Extrinsic and Intrinsic Apoptosis Pathways

(2010) N. Seki et al.   MOLECULAR CANCER THERAPEUTICS

α-TEA induces apoptosis of human breast cancer cells via activation of TRAIL/DR5 death receptor pathway

(2010) Weiping Yu et al.   MOLECULAR CARCINOGENESIS

Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis

(2010) Ling Zhang et al.   NATURE

Pancreatic cancer: understanding and overcoming chemoresistance

(2010) Zhiwei Wang et al.   Nature Reviews Gastroenterology & Hepatology

Inhibition of c-FLIP expression by miR-512-3p contributes to Taxol-induced apoptosis in hepatocellular carcinoma cells

(2010) Chen   ONCOLOGY REPORTS

The Novel Deacetylase Inhibitor AR-42 Demonstrates Pre-Clinical Activity in B-Cell Malignancies In Vitro and In Vivo

(2010) David M. Lucas et al.   PLoS One

c-FLIP Degradation Mediates Sensitization of Pancreatic Cancer Cells to TRAIL-Induced Apoptosis by the Histone Deacetylase Inhibitor LBH589

(2010) John Kauh et al.   PLoS One

Role of Endoplasmic Reticulum Stress in α-TEA Mediated TRAIL/DR5 Death Receptor Dependent Apoptosis

(2010) Richa Tiwary et al.   PLoS One

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

(2010) D. Ren et al.   SCIENCE

Escape of HIV-1-Infected Dendritic Cells from TRAIL-Mediated NK Cell Cytotoxicity during NK-DC Cross-Talk—A Pivotal Role of HMGB1

(2010) Marie-Thérèse Melki et al.   PLoS Pathogens

Bcl-2 family on guard at the ER

(2009) Eva Szegezdi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Lupeol triterpene, a novel diet-based microtubule targeting agent: Disrupts survivin/cFLIP activation in prostate cancer cells

(2009) Mohammad Saleem et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sensitization of imatinib-resistant CML cells to TRAIL-induced apoptosis is mediated through down-regulation of Bcr-Abl as well as c-FLIP

(2009) Soo-Jung Park et al.   BIOCHEMICAL JOURNAL

Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway

(2009) Soo-Jung Park et al.   BIOCHEMICAL PHARMACOLOGY

Sensitization of human K562 leukemic cells to TRAIL-induced apoptosis by inhibiting the DNA-PKcs/Akt-mediated cell survival pathway

(2009) Mi-Ju Kim et al.   BIOCHEMICAL PHARMACOLOGY

CAGE, a cancer/testis antigen, induces c-FLIPL and Snail to enhance cell motility and increase resistance to an anti-cancer drug

(2009) Youngmi Kim et al.   BIOTECHNOLOGY LETTERS

A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein

(2009) N. Ueffing et al.   BLOOD

High sensitivity of ovarian cancer cells to the synthetic triterpenoid CDDO-Imidazolide

(2009) Alessia Petronelli et al.   CANCER LETTERS

Transglutaminase 2 expression levels regulate sensitivity to cystamine plus TRAIL-mediated apoptosis

(2009) Ji Hoon Jang et al.   CANCER LETTERS

Suppression of cFLIP by Lupeol, a Dietary Triterpene, Is Sufficient to Overcome Resistance to TRAIL-Mediated Apoptosis in Chemoresistant Human Pancreatic Cancer Cells

(2009) I. Murtaza et al.   CANCER RESEARCH

A Novel PTEN-Dependent Link to Ubiquitination Controls FLIPS Stability and TRAIL Sensitivity in Glioblastoma Multiforme

(2009) A. Panner et al.   CANCER RESEARCH

Down-regulation of c-FLIP Enhances Death of Cancer Cells by Smac Mimetic Compound

(2009) H. H. Cheung et al.   CANCER RESEARCH

Inhibition of Ataxia Telangiectasia Mutated Kinase Activity Enhances TRAIL-Mediated Apoptosis in Human Melanoma Cells

(2009) V. N. Ivanov et al.   CANCER RESEARCH

Zerumbone Enhances TRAIL-Induced Apoptosis through the Induction of Death Receptors in Human Colon Cancer Cells: Evidence for an Essential Role of Reactive Oxygen Species

(2009) S. Yodkeeree et al.   CANCER RESEARCH

Caspases and Kinases in a Death Grip

(2009) Manabu Kurokawa et al.   CELL

PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability

(2009) A Kaunisto et al.   CELL DEATH AND DIFFERENTIATION

Molecular Mechanisms of Tamoxifen Therapy for Cholangiocarcinoma: Role of Calmodulin

(2009) P. Pawar et al.   CLINICAL CANCER RESEARCH

Cellular and nuclear degradation during apoptosis

(2009) Bin He et al.   CURRENT OPINION IN CELL BIOLOGY

Bortezomib restores stroma-mediated APO2L/TRAIL apoptosis resistance in multiple myeloma

(2009) Lia E. Perez et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Down-regulation of AMP-activated protein kinase sensitizes DU145 carcinoma to Fas-induced apoptosis via c-FLIP degradation

(2009) Seung-Nam Jung et al.   EXPERIMENTAL CELL RESEARCH

Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP

(2009) Tae-Jin Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cellular FLICE-inhibitory protein (c-FLIP) signalling: A key regulator of receptor-mediated apoptosis in physiologic context and in cancer

(2009) Marina Bagnoli et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Modulation of Wnt signaling by the nuclear localization of cellular FLIP-L

(2009) R. Katayama et al.   JOURNAL OF CELL SCIENCE

The therapeutic potential of p53 reactivation by nutlin-3a in ALK+ anaplastic large cell lymphoma with wild-type or mutated p53

(2009) E Drakos et al.   LEUKEMIA

RNA Interference in Cancer: Targeting the Anti-Apoptotic Protein c-FLIP for Drug Discovery

(2009) Travis Day et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistance

(2009) E. A. Perez   MOLECULAR CANCER THERAPEUTICS

Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms

(2009) T. Walker et al.   MOLECULAR PHARMACOLOGY

S-Adenosylmethionine and Methylthioadenosine Inhibit Cellular FLICE Inhibitory Protein Expression and Induce Apoptosis in Colon Cancer Cells

(2009) T. W. H. Li et al.   MOLECULAR PHARMACOLOGY

FLIP-mediated autophagy regulation in cell death control

(2009) Jong-Soo Lee et al.   NATURE CELL BIOLOGY

Genistein enhances proteasomal degradation of the short isoform of FLIP in malignant glioma cells and thereby augments TRAIL-mediated apoptosis

(2009) Markus David Siegelin et al.   NEUROSCIENCE LETTERS

Mechanism of procaspase-8 activation by c-FLIPL

(2009) J. W. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of changes in the proteome of HL-60 promyeloid leukemia cells induced by the proteasome inhibitor PSI

(2008) Mi-Ran Choi et al.   BIOCHEMICAL PHARMACOLOGY

c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells

(2008) Travis W. Day et al.   BIOCHEMICAL PHARMACOLOGY

Pentoxifylline induces apoptosis in vitro in cutaneous T cell lymphoma (HuT-78) and enhances FasL mediated killing by upregulating Fas expression

(2008) Loveena Rishi et al.   BIOCHEMICAL PHARMACOLOGY

Up-regulation of c-FLIPshort by NFAT contributes to apoptosis resistance of short-term activated T cells

(2008) N. Ueffing et al.   BLOOD

Cisplatin Induces p53-Dependent FLICE-Like Inhibitory Protein Ubiquitination in Ovarian Cancer Cells

(2008) M. R. Abedini et al.   CANCER RESEARCH

Bortezomib-induced apoptosis in mature T-cell lymphoma cells partially depends on upregulation of Noxa and functional repression of Mcl-1

(2008) Masaki Ri et al.   CANCER SCIENCE

Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment

(2008) N Ueffing et al.   CELL DEATH AND DIFFERENTIATION

E2F1 controls alternative splicing pattern of genes involved in apoptosis through upregulation of the splicing factor SC35

(2008) G Merdzhanova et al.   CELL DEATH AND DIFFERENTIATION

Vorinostat and Sorafenib Synergistically Kill Tumor Cells via FLIP Suppression and CD95 Activation

(2008) G. Zhang et al.   CLINICAL CANCER RESEARCH

Tumor Necrosis Factor: Renaissance as a Cancer Therapeutic?

(2008) D. Daniel et al.   CURRENT CANCER DRUG TARGETS

Cellular FLICE-Like Inhibitory Protein (C-FLIP): A Novel Target for Cancer Therapy

(2008) Ahmad Safa et al.   CURRENT CANCER DRUG TARGETS

FLIP ing the coin? Death receptor-mediated signals during skin tumorigenesis

(2008) Martin Leverkus et al.   EXPERIMENTAL DERMATOLOGY

TRAIL Recombinant Adenovirus Triggers Robust Apoptosis in Multidrug-Resistant HL-60/Vinc Cells Preferentially Through Death Receptor DR5

(2008) Ching-Huang Wu et al.   HUMAN GENE THERAPY

Overexpression of cFLIPs inhibits oxaliplatin-mediated apoptosis through enhanced XIAP stability and Akt activation in human renal cancer cells

(2008) Shin Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Involvement of c-FLIP and survivin down-regulation in flexible heteroarotinoid-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells

(2008) Y. Lin et al.   MOLECULAR CANCER THERAPEUTICS

Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95

(2008) M. A. Park et al.   MOLECULAR CANCER THERAPEUTICS

FLIP and the death effector domain family

(2008) J W Yu et al.   ONCOGENE

In vivo and in vitro studies of anticancer actions of α-TEA for human prostate cancer cells

(2008) Li Jia et al.   PROSTATE

FLIP as an Anti-Cancer Therapeutic Target

(2008) Jin Kuk Yang   YONSEI MEDICAL JOURNAL

ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells

(2007) V. Stagni et al.   BLOOD

Rosiglitazone promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP

(2007) Yeoun Hee Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: A gene expression profiling study with implications for potential combination therapies

(2007) Xiaoxian Zhao et al.   LEUKEMIA RESEARCH

Epidermal growth factor receptor inhibitors enhance susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells

(2007) Masayasu Iwase et al.   ORAL ONCOLOGY