Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors

Drug-induced Valvulopathy: An Update

(2010) Chandikumar S. Elangbam   TOXICOLOGIC PATHOLOGY

Dominant-Negative ALK2 Allele Associates With Congenital Heart Defects

(2009) Kelly A. Smith et al.   CIRCULATION

Rapid Generation of a High Quality Lead for Transforming Growth Factor-β (TGF-β) Type I Receptor (ALK5)†

(2009) Frederick W. Goldberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transforming Growth Factor-β Regulates in Vitro Heart Valve Repair by Activated Valve Interstitial Cells

(2008) Amber C. Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of transforming growth factor-β superfamily signaling pathways in human disease

(2008) Kelly J. Gordon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TGFβ in Cancer

(2008) Joan Massagué   CELL

TGF-β signaling in vascular biology and dysfunction

(2008) Marie-José Goumans et al.   CELL RESEARCH

Evolving Concepts of Cardiac Valve Dynamics

(2008) Frederick J. Schoen   CIRCULATION

Signaling via the Tgf-β type I receptor Alk5 in heart development

(2008) Somyoth Sridurongrit et al.   DEVELOPMENTAL BIOLOGY

TGFβ-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFβ switch

(2008) Irwin M Liu et al.   EMBO JOURNAL

5-Hydroxytryptamine (5HT)-induced valvulopathy: Compositional valvular alterations are associated with 5HT2B receptor and 5HT transporter transcript changes in Sprague-Dawley rats

(2008) Chandikumar S. Elangbam et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Optimization of a Dihydropyrrolopyrazole Series of Transforming Growth Factor-β Type I Receptor Kinase Domain Inhibitors: Discovery of an Orally Bioavailable Transforming Growth Factor-β Receptor Type I Inhibitor as Antitumor Agent

(2008) Hong-yu Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cardiac Valvular Pathology: Comparative Pathology and Animal Models of Acquired Cardiac Valvular Diseases

(2008) Kevin B. Donnelly   TOXICOLOGIC PATHOLOGY