标题
Dissecting fibrosis: therapeutic insights from the small-molecule toolbox
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 14, Issue 10, Pages 693-720
出版商
Springer Nature
发表日期
2015-09-04
DOI
10.1038/nrd4592
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis
- (2015) Katrin Palumbo-Zerr et al. NATURE MEDICINE
- The α v β 1 integrin plays a critical in vivo role in tissue fibrosis
- (2015) Nilgun I. Reed et al. Science Translational Medicine
- Strategic management of keloid disease in ethnic skin: a structured approach supported by the emerging literature
- (2015) S. Ud-Din et al. BRITISH JOURNAL OF DERMATOLOGY
- Identification of a Cell-of-Origin for Fibroblasts Comprising the Fibrotic Reticulum in Idiopathic Pulmonary Fibrosis
- (2014) Hong Xia et al. AMERICAN JOURNAL OF PATHOLOGY
- FRI0496 An Open-Label Study to Evaluate Biomarkers and Safety in Systemic Sclerosis (SSC) Patients Treated with Paquinimod (ABR-215757)
- (2014) R. Hesselstrand et al. ANNALS OF THE RHEUMATIC DISEASES
- Maraviroc, a CCR5 antagonist, ameliorates the development of hepatic steatosis in a mouse model of non-alcoholic fatty liver disease (NAFLD)
- (2014) L. Perez-Martinez et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- MMI-0100 inhibits cardiac fibrosis in myocardial infarction by direct actions on cardiomyocytes and fibroblasts via MK2 inhibition
- (2014) Lei Xu et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy
- (2014) J. C. Jha et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Phenotypic screening in cancer drug discovery — past, present and future
- (2014) John G. Moffat et al. NATURE REVIEWS DRUG DISCOVERY
- Molecular mechanisms of epithelial–mesenchymal transition
- (2014) Samy Lamouille et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Therapeutic approaches to diabetic nephropathy—beyond the RAS
- (2014) Beatriz Fernandez-Fernandez et al. Nature Reviews Nephrology
- A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis
- (2014) Talmadge E. King et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis
- (2014) Luca Richeldi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Randomized Trial of Acetylcysteine in Idiopathic Pulmonary Fibrosis
- (2014) NEW ENGLAND JOURNAL OF MEDICINE
- Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance
- (2014) L. Hecker et al. Science Translational Medicine
- Understanding CT patterns in idiopathic pulmonary fibrosis
- (2014) Simon P Hart Lancet Respiratory Medicine
- Assessment of Brd4 Inhibition in Idiopathic Pulmonary Fibrosis Lung Fibroblasts and in Vivo Models of Lung Fibrosis
- (2013) Xiaoyan Tang et al. AMERICAN JOURNAL OF PATHOLOGY
- Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis
- (2013) William McKleroy et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Role of Lung Pericytes and Resident Fibroblasts in the Pathogenesis of Pulmonary Fibrosis
- (2013) Chi Hung et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Peptide-Mediated Inhibition of Mitogen-Activated Protein Kinase–Activated Protein Kinase–2 Ameliorates Bleomycin-Induced Pulmonary Fibrosis
- (2013) Ragini Vittal et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Treatment of Idiopathic Pulmonary Fibrosis With Ambrisentan
- (2013) Ganesh Raghu ANNALS OF INTERNAL MEDICINE
- Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis
- (2013) Christian Beyer et al. ANNALS OF THE RHEUMATIC DISEASES
- Identification of steroid sensitive responders versus non-responders in the treatment of keloid disease
- (2013) Sara Ud-Din et al. ARCHIVES OF DERMATOLOGICAL RESEARCH
- The chemistry and biological activities of N-acetylcysteine
- (2013) Yuval Samuni et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Synthesis and biological evaluation of the pirfenidone derivatives as antifibrotic agents
- (2013) Zhen Ma et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Pharmacokinetics, Safety, and Tolerability of Saroglitazar (ZYH1), a Predominantly PPARα Agonist with Moderate PPARγ Agonist Activity in Healthy Human Subjects
- (2013) Rajendra H. Jani et al. CLINICAL DRUG INVESTIGATION
- Blockade of KCa3.1 Ameliorates Renal Fibrosis Through the TGF-β1/Smad Pathway in Diabetic Mice
- (2013) Chunling Huang et al. DIABETES
- Dual Peroxisome Proliferator-Activated Receptor / Agonist GFT505 Improves Hepatic and Peripheral Insulin Sensitivity in Abdominally Obese Subjects
- (2013) B. Cariou et al. DIABETES CARE
- Macitentan for the treatment of idiopathic pulmonary fibrosis: the randomised controlled MUSIC trial
- (2013) Ganesh Raghu et al. EUROPEAN RESPIRATORY JOURNAL
- Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease
- (2013) Sunder Mudaliar et al. GASTROENTEROLOGY
- Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
- (2013) Bart Staels et al. HEPATOLOGY
- BML-11, A Lipoxin Receptor Agonist, Protected Carbon Tetrachloride-Induced Hepatic Fibrosis in Rats
- (2013) Xiao-Yan Zhou et al. INFLAMMATION
- Protease-Activated Receptor 1 Inhibition by SCH79797 Attenuates Left Ventricular Remodeling and Profibrotic Activities of Cardiac Fibroblasts
- (2013) Dmitry L. Sonin et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
- Tocopherol Activity Correlates with Its Location in a Membrane: A New Perspective on the Antioxidant Vitamin E
- (2013) Drew Marquardt et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- 5-HT2Areceptor antagonists inhibit hepatic stellate cell activation and facilitate apoptosis
- (2013) Dong Chan Kim et al. LIVER INTERNATIONAL
- Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin
- (2013) A. M. Marz et al. MOLECULAR AND CELLULAR BIOLOGY
- The why and how of phenotypic small-molecule screens
- (2013) Ulrike S Eggert Nature Chemical Biology
- Heavy drugs draw heavy interest from pharma backers
- (2013) Alla Katsnelson NATURE MEDICINE
- Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis
- (2013) Valerie S LeBleu et al. NATURE MEDICINE
- Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs
- (2013) Neil C Henderson et al. NATURE MEDICINE
- Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease
- (2013) Dick de Zeeuw et al. NEW ENGLAND JOURNAL OF MEDICINE
- PKCδ as a Regulator for TGFβ1-Induced α-SMA Production in a Murine Nonalcoholic Steatohepatitis Model
- (2013) Su Jin Lee et al. PLoS One
- Maraviroc, a CCR5 Antagonist, Prevents Development of Hepatocellular Carcinoma in a Mouse Model
- (2013) Laura Ochoa-Callejero et al. PLoS One
- Pulmonary Autotaxin Expression Contributes to the Pathogenesis of Pulmonary Fibrosis
- (2012) Nikos Oikonomou et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis
- (2012) Nicole Reich et al. ANNALS OF THE RHEUMATIC DISEASES
- Targeted delivery of cytokine therapy to rheumatoid tissue by a synovial targeting peptide
- (2012) Sarah E Wythe et al. ANNALS OF THE RHEUMATIC DISEASES
- Pomalidomide is effective for prevention and treatment of experimental skin fibrosis
- (2012) Simon Weingärtner et al. ANNALS OF THE RHEUMATIC DISEASES
- Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling
- (2012) Alfiya Distler et al. ANNALS OF THE RHEUMATIC DISEASES
- Development of Focal Adhesion Kinase Inhibitors in Cancer Therapy
- (2012) Wen Wee Ma Anti-Cancer Agents in Medicinal Chemistry
- JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis
- (2012) Clara Dees et al. ARTHRITIS AND RHEUMATISM
- Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: Treprostinil is a potent DP1 and EP2 agonist
- (2012) Brendan J. Whittle et al. BIOCHEMICAL PHARMACOLOGY
- Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors
- (2012) Damien Y. Duveau et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity
- (2012) Alexander L. Ruchelman et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Imatinib mesylate in scleroderma-associated diffuse skin fibrosis: a phase II multicentre randomized double-blinded controlled trial
- (2012) S. Prey et al. BRITISH JOURNAL OF DERMATOLOGY
- Urinary Proteomics for Early Diagnosis in Diabetic Nephropathy
- (2012) P. Zurbig et al. DIABETES
- Corticosteroid Plus Pentoxifylline Is Not Better than Corticosteroid Alone for Improving Survival in Severe Alcoholic Hepatitis (COPE Trial)
- (2012) Sandeep Singh Sidhu et al. DIGESTIVE DISEASES AND SCIENCES
- Evaluation of the antifibrotic effect of fenofibrate and rosiglitazone on bleomycin-induced pulmonary fibrosis in rats
- (2012) M. Samah et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice
- (2012) Akihiro Takemasa et al. EUROPEAN RESPIRATORY JOURNAL
- Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo
- (2012) Joy X. Jiang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent
- (2012) Tomonori Aoyama et al. HEPATOLOGY
- Prostaglandin F2α facilitates collagen synthesis in cardiac fibroblasts via an F-prostanoid receptor/protein kinase C/Rho kinase pathway independent of transforming growth factor β1
- (2012) Wen-yuan Ding et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Bardoxolone Methyl Decreases Megalin and Activates Nrf2 in the Kidney
- (2012) S. A. Reisman et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Chemical genetic discovery of targets and anti-targets for cancer polypharmacology
- (2012) Arvin C. Dar et al. NATURE
- Automated design of ligands to polypharmacological profiles
- (2012) Jérémy Besnard et al. NATURE
- Stromedix acquisition signals growing interest in fibrosis
- (2012) Malorye Allison NATURE BIOTECHNOLOGY
- Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase
- (2012) Tracy L Keller et al. Nature Chemical Biology
- Multigenerational epigenetic adaptation of the hepatic wound-healing response
- (2012) Müjdat Zeybel et al. NATURE MEDICINE
- A systems approach identifies HIPK2 as a key regulator of kidney fibrosis
- (2012) Yuanmeng Jin et al. NATURE MEDICINE
- Ruxolitinib
- (2012) Ruben A. Mesa et al. NATURE REVIEWS DRUG DISCOVERY
- Targeting the TGFβ signalling pathway in disease
- (2012) Rosemary J. Akhurst et al. NATURE REVIEWS DRUG DISCOVERY
- Prednisone, Azathioprine, andN-Acetylcysteine for Pulmonary Fibrosis
- (2012) NEW ENGLAND JOURNAL OF MEDICINE
- Protection from liver fibrosis by a peroxisome proliferator-activated receptor agonist
- (2012) K. Iwaisako et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Proteasome inhibition improves diaphragm function in an animal model for COPD
- (2011) Hieronymus van Hees et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-β
- (2011) Nathan Sandbo et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Transglutaminase 2 and Its Role in Pulmonary Fibrosis
- (2011) Keith C. Olsen et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- BUILD-3: A Randomized, Controlled Trial of Bosentan in Idiopathic Pulmonary Fibrosis
- (2011) Talmadge E. King et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Regulation of Transforming Growth Factor-β1–driven Lung Fibrosis by Galectin-3
- (2011) Alison C. MacKinnon et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Therapeutic Value of Small Molecule Inhibitor to Plasminogen Activator Inhibitor–1 for Lung Fibrosis
- (2011) Wen-Tan Huang et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation
- (2011) David Lagares et al. ARTHRITIS AND RHEUMATISM
- Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin
- (2011) Guowei Jiang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor
- (2011) Véronique Plantevin Krenitsky et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Novel therapeutic approaches for pulmonary fibrosis
- (2011) Arnab Datta et al. BRITISH JOURNAL OF PHARMACOLOGY
- Sorafenib inhibits transforming growth factor β1-Mediated Epithelial-Mesenchymal Transition and apoptosis in mouse hepatocytes
- (2011) Yue-Lei Chen et al. HEPATOLOGY
- P2X7 receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats
- (2011) Xu Ji et al. HYPERTENSION RESEARCH
- Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib
- (2011) Yuqing Liu et al. JOURNAL OF HEPATOLOGY
- Peptide Inhibitors of MK2 Show Promise for Inhibition of Abdominal Adhesions
- (2011) Brian C. Ward et al. JOURNAL OF SURGICAL RESEARCH
- Nilotinib Attenuates Renal Injury and Prolongs Survival in Chronic Kidney Disease
- (2011) M. Iyoda et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Addition of Atrasentan to Renin-Angiotensin System Blockade Reduces Albuminuria in Diabetic Nephropathy
- (2011) D. E. Kohan et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Pirfenidone for Diabetic Nephropathy
- (2011) K. Sharma et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials
- (2011) Paul W Noble et al. LANCET
- How were new medicines discovered?
- (2011) David C. Swinney et al. NATURE REVIEWS DRUG DISCOVERY
- Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes
- (2011) Pablo E. Pergola et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Multiwell Platform for Studying Stiffness-Dependent Cell Biology
- (2011) Justin D. Mih et al. PLoS One
- Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition
- (2011) J. R. Rock et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effect of Nilotinib on Bleomycin-Induced Acute Lung Injury and Pulmonary Fibrosis in Mice
- (2011) Chin Kook Rhee et al. RESPIRATION
- An investigator-driven study of everolimus in surgical lung biopsy confirmed idiopathic pulmonary fibrosis
- (2011) MONIQUE A. MALOUF et al. RESPIROLOGY
- Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors
- (2011) Mark J. Anderton et al. TOXICOLOGIC PATHOLOGY
- Inhibition of Mitogen Activated Protein Kinase Activated Protein Kinase II with MMI-0100 reduces intimal hyperplasia ex vivo and in vivo
- (2011) Akihito Muto et al. VASCULAR PHARMACOLOGY
- Hypermethylation of PTGER2 Confers Prostaglandin E2 Resistance in Fibrotic Fibroblasts from Humans and Mice
- (2010) Steven K. Huang et al. AMERICAN JOURNAL OF PATHOLOGY
- Diminished Prostaglandin E2Contributes to the Apoptosis Paradox in Idiopathic Pulmonary Fibrosis
- (2010) Toby M. Maher et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Reply
- (2010) James R. Seibold et al. ARTHRITIS AND RHEUMATISM
- Prevention of diabetic nephropathy in Ins2+/−AkitaJmice by the mitochondria-targeted therapy MitoQ
- (2010) Balu K. Chacko et al. BIOCHEMICAL JOURNAL
- A novel, orally active LPA1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin model
- (2010) JS Swaney et al. BRITISH JOURNAL OF PHARMACOLOGY
- Blockade of Endothelial-Mesenchymal Transition by a Smad3 Inhibitor Delays the Early Development of Streptozotocin-Induced Diabetic Nephropathy
- (2010) J. Li et al. DIABETES
- Inhibitory effect of CXC chemokine receptor 4 antagonist AMD3100 on bleomycin induced murine pulmonary fibrosis
- (2010) Jeong Sup Song et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Modulation of Lysyl Oxidase-like 2 Enzymatic Activity by an Allosteric Antibody Inhibitor
- (2010) Hector M. Rodriguez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression
- (2010) Fei Liu et al. JOURNAL OF CELL BIOLOGY
- A Novel Inhibitor of Plasminogen Activator Inhibitor-1 Provides Antithrombotic Benefits Devoid of Bleeding Effect in Nonhuman Primates
- (2010) Yuko Izuhara et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis
- (2010) Yan Wang et al. JOURNAL OF HEPATOLOGY
- The chemokine monocyte chemoattractant protein-1 contributes to renal dysfunction in swine renovascular hypertension
- (2010) Xiang-Yang Zhu et al. JOURNAL OF HYPERTENSION
- Selective Inhibition of JAK1 and JAK2 Is Efficacious in Rodent Models of Arthritis: Preclinical Characterization of INCB028050
- (2010) J. S. Fridman et al. JOURNAL OF IMMUNOLOGY
- First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis
- (2010) Benoı̂t Laleu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Prevention of Bleomycin-Induced Pulmonary Fibrosis by a Novel Antifibrotic Peptide with Relaxin-Like Activity
- (2010) A. Pini et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Selective inhibition of BET bromodomains
- (2010) Panagis Filippakopoulos et al. NATURE
- Methylation determines fibroblast activation and fibrogenesis in the kidney
- (2010) Wibke Bechtel et al. NATURE MEDICINE
- Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment
- (2010) Vivian Barry-Hamilton et al. NATURE MEDICINE
- Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
- (2010) Arun J. Sanyal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inhibition of Wnt/ -catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis
- (2010) W. R. Henderson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis
- (2009) Benjamin D. Humphreys et al. AMERICAN JOURNAL OF PATHOLOGY
- Endothelin antagonism in portal hypertensive mice: implications for endothelin receptor-specific signaling in liver disease
- (2009) Hong-Qiang Feng et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C
- (2009) Jordi Colmenero et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Imatinib Treatment for Idiopathic Pulmonary Fibrosis
- (2009) Craig E. Daniels et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Rapamycin Prevents Transforming Growth Factor-α–Induced Pulmonary Fibrosis
- (2009) Thomas R. Korfhagen et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis
- (2009) Jelena Mann et al. GASTROENTEROLOGY
- Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: Results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial
- (2009) Vlad Ratziu et al. HEPATOLOGY
- CCR2 promotes hepatic fibrosis in mice
- (2009) Ekihiro Seki et al. HEPATOLOGY
- Anti-fibrotic effect of thalidomide through inhibiting TGF-β-induced ERK1/2 pathways in bleomycin-induced lung fibrosis in mice
- (2009) Jung-Yoon Choe et al. INFLAMMATION RESEARCH
- Increased TG2 Expression Can Result in Induction of Transforming Growth Factor β1, Causing Increased Synthesis and Deposition of Matrix Proteins, Which Can Be Regulated by Nitric Oxide
- (2009) Dilek Telci et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Transglutaminase inhibition ameliorates experimental diabetic nephropathy
- (2009) Linghong Huang et al. KIDNEY INTERNATIONAL
- Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
- (2009) Shih-Min A. Huang et al. NATURE
- Open access chemical and clinical probes to support drug discovery
- (2009) Aled M Edwards et al. Nature Chemical Biology
- Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels
- (2009) I. Grgic et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effect of beraprost sodium (BPS) in a new rat partial unilateral ureteral obstruction model
- (2009) Masahiko Takenaka et al. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
- Halofuginone Inhibits TH17 Cell Differentiation by Activating the Amino Acid Starvation Response
- (2009) M. S. Sundrud et al. SCIENCE
- Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides
- (2009) Per Björk et al. PLOS BIOLOGY
- Tissue stiffness, latent TGF-β1 Activation, and mechanical signal transduction: Implications for the pathogenesis and treatment of fibrosis
- (2009) Boris Hinz Current Rheumatology Reports
- Adenoviral Overexpression and Small Interfering RNA Suppression Demonstrate That Plasminogen Activator Inhibitor-1 Produces Elevated Collagen Accumulation in Normal and Keloid Fibroblasts
- (2008) Tai-Lan Tuan et al. AMERICAN JOURNAL OF PATHOLOGY
- c-Jun N-Terminal Kinase 1 Is Required for the Development of Pulmonary Fibrosis
- (2008) John F. Alcorn et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Superoxide scavenging activity of pirfenidone–iron complex
- (2008) Yoshihiro Mitani et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- BIBF 1120: Triple Angiokinase Inhibitor with Sustained Receptor Blockade and Good Antitumor Efficacy
- (2008) F. Hilberg et al. CANCER RESEARCH
- A synthetic peptide from transforming growth factor- 1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats
- (2008) N. Hermida et al. CARDIOVASCULAR RESEARCH
- Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis
- (2008) Alfiya Akhmetshina et al. FASEB JOURNAL
- Inhibition of Integrin αvβ6 on Cholangiocytes Blocks Transforming Growth Factor-β Activation and Retards Biliary Fibrosis Progression
- (2008) Eleonora Patsenker et al. GASTROENTEROLOGY
- Mechanisms of Hepatic Fibrogenesis
- (2008) Scott L. Friedman GASTROENTEROLOGY
- Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis
- (2008) Annika Andersson-Sjöland et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist
- (2008) M. Iglarz et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- T-type calcium channel blockade as a therapeutic strategy against renal injury in rats with subtotal nephrectomy
- (2008) N. Sugano et al. KIDNEY INTERNATIONAL
- Liver cirrhosis
- (2008) Detlef Schuppan et al. LANCET
- Cytosporone B is an agonist for nuclear orphan receptor Nur77
- (2008) Yanyan Zhan et al. Nature Chemical Biology
- Network pharmacology: the next paradigm in drug discovery
- (2008) Andrew L Hopkins Nature Chemical Biology
- Aliskiren Combined with Losartan in Type 2 Diabetes and Nephropathy
- (2008) Hans-Henrik Parving et al. NEW ENGLAND JOURNAL OF MEDICINE
- Functional Wnt Signaling Is Increased in Idiopathic Pulmonary Fibrosis
- (2008) Melanie Königshoff et al. PLoS One
- Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures
- (2007) Anna Maria Brunati et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?
- (2007) Antje Moeller et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Pirfenidone inhibits the expression of HSP47 in TGF-β1-stimulated human lung fibroblasts
- (2007) Seiko Nakayama et al. LIFE SCIENCES
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