The why and how of phenotypic small-molecule screens

Target identification and mechanism of action in chemical biology and drug discovery

(2013) Monica Schenone et al.   Nature Chemical Biology

Colloidal Aggregation Affects the Efficacy of Anticancer Drugs in Cell Culture

(2012) Shawn C. Owen et al.   ACS Chemical Biology

Identifying mechanism-of-action targets for drugs and probes

(2012) E. Gregori-Puigjane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopamine receptor D3 regulates endocytic sorting by a Prazosin-sensitive interaction with the coatomer COPI

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition

(2011) Lisa von Kleist et al.   CELL

Searching for the Protein Targets of Bioactive Molecules

(2011) Christopher Chidley et al.   CHIMIA

Too many roads not taken

(2011) Aled M. Edwards et al.   NATURE

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Small Molecule Probes of Cellular Pathways and Networks

(2010) Adam B. Castoreno et al.   ACS Chemical Biology

Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis

(2010) Adam B Castoreno et al.   Nature Chemical Biology

The art of the chemical probe

(2010) Stephen V Frye   Nature Chemical Biology

Target profiling of small molecules by chemical proteomics

(2009) Uwe Rix et al.   Nature Chemical Biology

Open access chemical and clinical probes to support drug discovery

(2009) Aled M Edwards et al.   Nature Chemical Biology