Tumor-associated macrophages and anti-tumor therapies: complex links

Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages

(2015) C. Frankenberger et al.   CANCER RESEARCH

PTX3 Is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in Cancer

(2015) Eduardo Bonavita et al.   CELL

The interaction of anticancer therapies with tumor-associated macrophages

(2015) Alberto Mantovani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophages are critical effectors of antibody therapies for cancer

(2015) Kipp Weiskopf et al.   mAbs

Non-Viral Nanoparticle Delivers Small Interfering RNA to Macrophages In Vitro and In Vivo

(2015) Mei Zhang et al.   PLoS One

Anti-vascular endothelial growth factor therapy-induced glioma invasion is associated with accumulation of Tie2-expressing monocytes

(2015) Konrad Gabrusiewicz et al.   Oncotarget

Classification of current anticancer immunotherapies

(2015) Lorenzo Galluzzi et al.   Oncotarget

The Chemokine CCL2 Increases Prostate Tumor Growth and Bone Metastasis through Macrophage and Osteoclast Recruitment

(2015) Kosuke Mizutani et al.   NEOPLASIA

CSF-1R Expression in Tumor-Associated Macrophages Is Associated With Worse Prognosis in Classical Hodgkin Lymphoma

(2014) Young Wha Koh et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Trabectedin, a drug acting on both cancer cells and the tumour microenvironment

(2014) M D’Incalci et al.   BRITISH JOURNAL OF CANCER

A Positive Feedback Loop between Mesenchymal-like Cancer Cells and Macrophages Is Essential to Breast Cancer Metastasis

(2014) Shicheng Su et al.   CANCER CELL

Postsurgical Adjuvant Tumor Therapy by Combining Anti-Angiopoietin-2 and Metronomic Chemotherapy Limits Metastatic Growth

(2014) Kshitij Srivastava et al.   CANCER CELL

B Cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous Carcinomas

(2014) Nesrine I. Affara et al.   CANCER CELL

Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy

(2014) Carola H. Ries et al.   CANCER CELL

Osteopontin Shapes Immunosuppression in the Metastatic Niche

(2014) Sabina Sangaletti et al.   CANCER RESEARCH

In situ proliferation contributes to accumulation of tumor-associated macrophages in spontaneous mammary tumors

(2014) Piotr Tymoszuk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Therapeutic potentials of gene silencing by RNA interference: Principles, challenges, and new strategies

(2014) Yan Deng et al.   GENE

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Key role for myeloid cells: Phase II results of anti-GD2antibody 3F8 plus granulocyte-macrophage colony-stimulating factor for chemoresistant osteomedullary neuroblastoma

(2014) Nai-Kong V. Cheung et al.   INTERNATIONAL JOURNAL OF CANCER

Enhancement of paclitaxel and carboplatin therapies by CCL2 blockade in ovarian cancers

(2014) Francois Moisan et al.   Molecular Oncology

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages

(2014) Haihui Lu et al.   NATURE CELL BIOLOGY

Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes

(2014) F. H. W. Shand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cellular and molecular origin of tumor-associated macrophages

(2014) R. A. Franklin et al.   SCIENCE

Invasive breast carcinoma cells from patients exhibit MenaINV- and macrophage-dependent transendothelial migration

(2014) J. Pignatelli et al.   Science Signaling

Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: an open-label, multicenter phase 1b study

(2014) Irene Brana et al.   Targeted Oncology

Impact of tumour microenvironment and Fc receptors on the activity of immunomodulatory antibodies

(2014) Andrew J.S. Furness et al.   TRENDS IN IMMUNOLOGY

Depletion of Tumor-Associated Macrophages Slows the Growth of Chemically Induced Mouse Lung Adenocarcinomas

(2014) Jason M. Fritz et al.   Frontiers in Immunology

Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death

(2014) Encouse B Golden et al.   OncoImmunology

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

(2013) Giovanni Germano et al.   CANCER CELL

Low-Dose Irradiation Programs Macrophage Differentiation to an iNOS+/M1 Phenotype that Orchestrates Effective T Cell Immunotherapy

(2013) Felix Klug et al.   CANCER CELL

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

Macrophage Regulation of Tumor Responses to Anticancer Therapies

(2013) Michele De Palma et al.   CANCER CELL

A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors

(2013) Shahneen K. Sandhu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The chemokine system, and its CCR5 and CXCR4 receptors, as potential targets for personalized therapy in cancer

(2013) Polina Weitzenfeld et al.   CANCER LETTERS

Chemotherapy Alters Monocyte Differentiation to Favor Generation of Cancer-Supporting M2 Macrophages in the Tumor Microenvironment

(2013) E. M. Dijkgraaf et al.   CANCER RESEARCH

Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

(2013) D. Laoui et al.   CANCER RESEARCH

CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer

(2013) J. Xu et al.   CANCER RESEARCH

Inhibition of CSF-1 Receptor Improves the Antitumor Efficacy of Adoptive Cell Transfer Immunotherapy

(2013) S. Mok et al.   CANCER RESEARCH

A Phase I Study of an Agonist CD40 Monoclonal Antibody (CP-870,893) in Combination with Gemcitabine in Patients with Advanced Pancreatic Ductal Adenocarcinoma

(2013) G. L. Beatty et al.   CLINICAL CANCER RESEARCH

Elevated CSF1 serum concentration predicts poor overall survival in women with early breast cancer

(2013) Seyedhossein Aharinejad et al.   ENDOCRINE-RELATED CANCER

Mixed-polarization phenotype of ascites-associated macrophages in human ovarian carcinoma: Correlation of CD163 expression, cytokine levels and early relapse

(2013) Silke Reinartz et al.   INTERNATIONAL JOURNAL OF CANCER

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

(2013) Tyler R. Simpson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage Heterogeneity in Respiratory Diseases

(2013) Carian E. Boorsma et al.   MEDIATORS OF INFLAMMATION

On the Mechanism and Benefit of siRNA-mediated Targeting of CD47 in Cancer

(2013) Xiwen Zhao et al.   MOLECULAR THERAPY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Strategies for optimizing the response of cancer and normal tissues to radiation

(2013) Everett J. Moding et al.   NATURE REVIEWS DRUG DISCOVERY

Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma

(2013) C. Lu-Emerson et al.   NEURO-ONCOLOGY

Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase

(2013) N Weizman et al.   ONCOGENE

Direct Proteomic Quantification of the Secretome of Activated Immune Cells

(2013) F. Meissner et al.   SCIENCE

Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?

(2013) L. M. Coussens et al.   SCIENCE

Antibody Therapeutics in Cancer

(2013) M. X. Sliwkowski et al.   SCIENCE

Immunologically augmented cancer treatment using modern radiotherapy

(2013) Marco Durante et al.   TRENDS IN MOLECULAR MEDICINE

Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells

(2013) M. J. Selby et al.   Cancer Immunology Research

An Abscopal Response to Radiation and Ipilimumab in a Patient with Metastatic Non-Small Cell Lung Cancer

(2013) E. B. Golden et al.   Cancer Immunology Research

Macrophage-tumor cell interactions regulate the function of nitric oxide

(2013) Michal A. Rahat et al.   Frontiers in Physiology

The irradiated tumor microenvironment: role of tumor-associated macrophages in vascular recovery

(2013) Jeffery S. Russell et al.   Frontiers in Physiology

Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition

(2012) Carlos E. Prada et al.   ACTA NEUROPATHOLOGICA

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Imaging Tumor-Stroma Interactions during Chemotherapy Reveals Contributions of the Microenvironment to Resistance

(2012) Elizabeth S. Nakasone et al.   CANCER CELL

Angiopoietin-2 Functions as a Tie2 Agonist in Tumor Models, Where It Limits the Effects of VEGF Inhibition

(2012) C. Daly et al.   CANCER RESEARCH

CCR5 Antagonist Blocks Metastasis of Basal Breast Cancer Cells

(2012) M. Velasco-Velazquez et al.   CANCER RESEARCH

Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses

(2012) J. B. Mitchem et al.   CANCER RESEARCH

Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models

(2012) Massimo Zollo et al.   CLINICAL & EXPERIMENTAL METASTASIS

Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer

(2012) Kenneth J. Pienta et al.   INVESTIGATIONAL NEW DRUGS

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

(2012) Mélanie Bruchard et al.   NATURE MEDICINE

The Distribution of Macrophages with a M1 or M2 Phenotype in Relation to Prognosis and the Molecular Characteristics of Colorectal Cancer

(2012) Sofia Edin et al.   PLoS One

Differential macrophage programming in the tumor microenvironment

(2012) Brian Ruffell et al.   TRENDS IN IMMUNOLOGY

Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling

(2011) D. A. Hume et al.   BLOOD

Transition of tumor-associated macrophages from MHC class IIhi to MHC class IIlow mediates tumor progression in mice

(2011) Benfan Wang et al.   BMC IMMUNOLOGY

Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells

(2011) Roberta Mazzieri et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer

(2011) T. Shree et al.   GENES & DEVELOPMENT

TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice

(2011) Abigail F. Welford et al.   JOURNAL OF CLINICAL INVESTIGATION

Evaluation of Oncology Drugs at the European Medicines Agency and US Food and Drug Administration: When Differences Have an Impact on Clinical Practice

(2011) Francesco Trotta et al.   JOURNAL OF CLINICAL ONCOLOGY

Deficiency of the macrophage growth factor CSF-1 disrupts pancreatic neuroendocrine tumor development

(2011) S M Pyonteck et al.   ONCOGENE

Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells

(2011) M. Jinushi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

(2011) David G. DeNardo et al.   Cancer Discovery

Elusive Identities and Overlapping Phenotypes of Proangiogenic Myeloid Cells in Tumors

(2010) Seth B. Coffelt et al.   AMERICAN JOURNAL OF PATHOLOGY

Cigarette Smoke-Induced Changes to Alveolar Macrophage Phenotype and Function Are Improved by Treatment with Procysteine

(2010) Sandra Hodge et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Fc R2A and 3A polymorphisms predict clinical outcome of trastuzumab in both neoadjuvant and metastatic settings in patients with HER2-positive breast cancer

(2010) K. Tamura et al.   ANNALS OF ONCOLOGY

The Therapeutic Effect of Anti-HER2/neu Antibody Depends on Both Innate and Adaptive Immunity

(2010) SaeGwang Park et al.   CANCER CELL

Antitumor and Anti-inflammatory Effects of Trabectedin on Human Myxoid Liposarcoma Cells

(2010) G. Germano et al.   CANCER RESEARCH

Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma

(2010) Mark P. Chao et al.   CELL

Depletion of Tumor-Associated Macrophages Enhances the Effect of Sorafenib in Metastatic Liver Cancer Models by Antimetastatic and Antiangiogenic Effects

(2010) W. Zhang et al.   CLINICAL CANCER RESEARCH

A Novel Chemoimmunomodulating Property of Docetaxel: Suppression of Myeloid-Derived Suppressor Cells in Tumor Bearers

(2010) K. N. Kodumudi et al.   CLINICAL CANCER RESEARCH

Inhibition of STAT3 Signaling Blocks the Anti-apoptotic Activity of IL-6 in Human Liver Cancer Cells

(2010) Yan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism

(2010) Michael J. Rogers et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bisphosphonates in vitro specifically inhibit, among the hematopoietic series, the development of the mouse mononuclear phagocyte lineage

(2010) Marco G. Cecchini et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice

(2010) Mitomu Kioi et al.   JOURNAL OF CLINICAL INVESTIGATION

Successful Colon Cancer Eradication after Chemoimmunotherapy Is Associated with Profound Phenotypic Change of Intratumoral Myeloid Cells

(2010) J. Medina-Echeverz et al.   JOURNAL OF IMMUNOLOGY

The Tumor-Immune Microenvironment and Response to Radiation Therapy

(2010) Stephen L. Shiao et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

A Review of Trabectedin (ET-743): A Unique Mechanism of Action

(2010) Maurizio D'Incalci et al.   MOLECULAR CANCER THERAPEUTICS

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

High Expression of Macrophage Colony-Stimulating Factor-1 Receptor in Peritumoral Liver Tissue Is Associated with Poor Outcome in Hepatocellular Carcinoma After Curative Resection

(2010) J.-B. Jia et al.   ONCOLOGIST

Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment

(2010) G.-O. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages as mediators of tumor immunosurveillance

(2010) Siddhartha Jaiswal et al.   TRENDS IN IMMUNOLOGY

Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy

(2009) S. J. Priceman et al.   BLOOD

The Macrophage Colony-Stimulating Factor 1 Response Signature in Breast Carcinoma

(2009) A. H. Beck et al.   CLINICAL CANCER RESEARCH

The chemokine system in cancer biology and therapy

(2009) Alberto Mantovani et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Chemokine (C-C Motif) Ligand 2 Engages CCR2+Stromal Cells of Monocytic Origin to Promote Breast Cancer Metastasis to Lung and Bone

(2009) Xin Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor-associated macrophages are predominant carriers of cyclodextrin-based nanoparticles into gliomas

(2009) Darya Alizadeh et al.   Nanomedicine-Nanotechnology Biology and Medicine

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

Granulocyte-Macrophage Colony-Stimulating Factor Potentiates Rituximab in Patients With Relapsed Follicular Lymphoma: Results of a Phase II Study

(2008) Guillaume Cartron et al.   JOURNAL OF CLINICAL ONCOLOGY

High Expression of Macrophage Colony-Stimulating Factor in Peritumoral Liver Tissue Is Associated With Poor Survival After Curative Resection of Hepatocellular Carcinoma

(2008) Xiao-Dong Zhu et al.   JOURNAL OF CLINICAL ONCOLOGY

“Re-educating” tumor-associated macrophages by targeting NF-κB

(2008) Thorsten Hagemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting tumor-associated macrophages in an orthotopic murine model of diffuse malignant mesothelioma

(2008) N. R. Miselis et al.   MOLECULAR CANCER THERAPEUTICS

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Stromal gene expression predicts clinical outcome in breast cancer

(2008) Greg Finak et al.   NATURE MEDICINE

Stromal Gene Signatures in Large-B-Cell Lymphomas

(2008) G. Lenz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nitric oxide, apoptosis and macrophage polarization during tumor progression

(2008) Andreas Weigert et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY