LAG-3 confers poor prognosis and its blockade reshapes antitumor response in head and neck squamous cell carcinoma

Head and Neck Cancers, Version 2.2014

(2017) David G. Pfister et al.   Journal of the National Comprehensive Cancer Network

Checkpoint Inhibitors in Head and Neck Cancer: Rationale, Clinical Activity, and Potential Biomarkers

(2016) Panagiota Economopoulou et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation

(2016) Ana C. Anderson et al.   IMMUNITY

CTLA4 blockade reduces immature myeloid cells in head and neck squamous cell carcinoma

(2016) Guang-Tao Yu et al.   OncoImmunology

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Orchestration and Prognostic Significance of Immune Checkpoints in the Microenvironment of Primary and Metastatic Renal Cell Cancer

(2015) N. A. Giraldo et al.   CLINICAL CANCER RESEARCH

Progesterone protects endothelial cells after cerebrovascular occlusion by decreasing MCP-1- and CXCL1-mediated macrophage infiltration

(2015) Ebony Washington Remus et al.   EXPERIMENTAL NEUROLOGY

Immunology and Immunotherapy of Head and Neck Cancer

(2015) Robert L. Ferris   JOURNAL OF CLINICAL ONCOLOGY

Comprehensive genomic characterization of head and neck squamous cell carcinomas

(2015)   NATURE

PD-1 blockade attenuates immunosuppressive myeloid cells due to inhibition of CD47/SIRPα axis in HPV negative head and neck squamous cell carcinoma

(2015) Guang-Tao Yu et al.   Oncotarget

LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model

(2015) Ruea-Yea Huang et al.   Oncotarget

Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner

(2015) Rikke B. Holmgaard et al.   Cell Reports

CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function

(2015) Eunyoung Chun et al.   Cell Reports

LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses

(2014) F. Xu et al.   CANCER RESEARCH

Tadalafil Reduces Myeloid-Derived Suppressor Cells and Regulatory T Cells and Promotes Tumor Immunity in Patients with Head and Neck Squamous Cell Carcinoma

(2014) D. T. Weed et al.   CLINICAL CANCER RESEARCH

The effect of immune microenvironment on the progression and prognosis of colorectal cancer

(2014) Jinxiang Chen et al.   MEDICAL ONCOLOGY

TAM macrophages promote growth and metastasis within the cancer ecosystem

(2014) Jelani C Zarif et al.   OncoImmunology

Lymphocyte activation gene-3 (LAG-3, CD223) in plasmacytoid dendritic cells (pDCs): a molecular target for the restoration of active antitumor immunity

(2014) Chiara Castelli et al.   OncoImmunology

Integrating novel therapeutic monoclonal antibodies into the management of head and neck cancer

(2013) Julie E. Bauman et al.   CANCER

MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma

(2013) Lu Zhang et al.   CANCER LETTERS

Clinical significance of macrophage heterogeneity in human malignant tumors

(2013) Yoshihiro Komohara et al.   CANCER SCIENCE

Nivolumab plus Ipilimumab in Advanced Melanoma

(2013) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Significance of Keap1 and Nrf2 in Oral Squamous Cell Carcinoma

(2013) Cong-Fa Huang et al.   PLoS One

Chemopreventive and Chemotherapeutic Actions of mTOR Inhibitor in Genetically Defined Head and Neck Squamous Cell Carcinoma Mouse Model

(2012) Z.-J. Sun et al.   CLINICAL CANCER RESEARCH

Randomized Phase III Trial of Induction Chemotherapy With Docetaxel, Cisplatin, and Fluorouracil Followed by Surgery Versus Up-Front Surgery in Locally Advanced Resectable Oral Squamous Cell Carcinoma

(2012) Lai-ping Zhong et al.   JOURNAL OF CLINICAL ONCOLOGY

Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo

(2012) J.-s. Do et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape

(2011) S.-R. Woo et al.   CANCER RESEARCH

The chemokine system and cancer

(2011) Frances R Balkwill   JOURNAL OF PATHOLOGY

Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation

(2011) Y Bian et al.   ONCOGENE

The CD4-like molecule LAG-3, biology and therapeutic applications

(2010) Sophie Sierro et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function

(2010) Leif E. Sander et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tumor-infiltrating NY-ESO-1–specific CD8+T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer

(2010) Junko Matsuzaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progressive Tumor Formation in Mice with Conditional Deletion of TGF-  Signaling in Head and Neck Epithelia Is Associated with Activation of the PI3K/Akt Pathway

(2009) Y. Bian et al.   CANCER RESEARCH

Coordination of Intratumoral Immune Reaction and Human Colorectal Cancer Recurrence

(2009) M. Camus et al.   CANCER RESEARCH

Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer

(2009) S. Ostrand-Rosenberg et al.   JOURNAL OF IMMUNOLOGY

Regulatory T cells: What role do they play in antitumor immunity in patients with head and neck cancer?

(2008) Osama Alhamarneh et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Dysregulated molecular networks in head and neck carcinogenesis

(2008) Alfredo A. Molinolo et al.   ORAL ONCOLOGY