How biologics targeting the IL-1 system are being considered for the treatment of type 2 diabetes

The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes

(2013) Allison B. Goldfine   ANNALS OF INTERNAL MEDICINE

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

(2011) Paul M Ridker et al.   AMERICAN HEART JOURNAL

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Increased IL-1β activation, the culprit not only for defective insulin secretion but also for insulin resistance?

(2011) Marianne Böni-Schnetzler et al.   CELL RESEARCH

Globalization of Diabetes: The role of diet, lifestyle, and genes

(2011) F. B. Hu   DIABETES CARE

Treatment with Anakinra Improves Disposition Index But Not Insulin Sensitivity in Nondiabetic Subjects with the Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study

(2011) Edwin J. P. van Asseldonk et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Accelerated Increase in Serum Interleukin-1 Receptor Antagonist Starts 6 Years Before Diagnosis of Type 2 Diabetes: Whitehall II Prospective Cohort Study

(2010) M. Carstensen et al.   DIABETES

Interleukin-1β May Mediate Insulin Resistance in Liver-Derived Cells in Response to Adipocyte Inflammation

(2010) Ori Nov et al.   ENDOCRINOLOGY

Genetics of type 2 diabetes: pathophysiologic and clinical relevance

(2010) Christian Herder et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Kinetic Approach to Pathway Attenuation Using XOMA 052, a Regulatory Therapeutic Antibody That Modulates Interleukin-1β Activity

(2010) Marina K. Roell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Prevalence of Diabetes among Men and Women in China

(2010) Wenying Yang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes

(2009) C. M. Larsen et al.   DIABETES CARE

Islet-associated macrophages in type 2 diabetes

(2009) S. J. Richardson et al.   DIABETOLOGIA

Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I

(2009) Marianne Böni-Schnetzler et al.   ENDOCRINOLOGY

Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study

(2009) Adam G Tabák et al.   LANCET

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Islet Inflammation Impairs the Pancreatic β-Cell in Type 2 Diabetes

(2009) Marc Y. Donath et al.   PHYSIOLOGY

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat

(2009) J. A. Ehses et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated Levels of the Anti-Inflammatory Interleukin-1 Receptor Antagonist Precede the Onset of Type 2 Diabetes: The Whitehall II Study

(2008) C. Herder et al.   DIABETES CARE

Increased Interleukin (IL)-1β Messenger Ribonucleic Acid Expression in β-Cells of Individuals with Type 2 Diabetes and Regulation of IL-1β in Human Islets by Glucose and Autostimulation

(2008) Marianne Böni-Schnetzler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE