Toll/interleukin-1 receptor (TIR) domain-mediated cellular signaling pathways

Interacting Neuroendocrine and Innate and Acquired Immune Pathways Regulate Neutrophil Mobilization from Bone Marrow following Hemorrhagic Shock

(2014) Y. Liu et al.   JOURNAL OF IMMUNOLOGY

Crystal Structure of TIR Domain of TLR6 Reveals Novel Dimeric Interface of TIR–TIR Interaction for Toll-Like Receptor Signaling Pathway

(2014) Tae-ho Jang et al.   JOURNAL OF MOLECULAR BIOLOGY

Suppression of TLR Signaling by Targeting TIR domain-Containing Proteins

(2013) Ota Fekonja et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Non-canonical IKKs, IKKϵ and TBK1, as novel therapeutic targets in the treatment of non-small cell lung cancer

(2013) Jae-Young Kim et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses

(2012) Lara M Kingeter et al.   Cellular & Molecular Immunology

A new eye on NLR proteins: focused on clarity or diffused by complexity?

(2012) Vera Bonardi et al.   CURRENT OPINION IN IMMUNOLOGY

Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 Signaling

(2012) Zhijie Lin et al.   PLoS One

Regulation of RLR-mediated innate immune signaling – It is all about keeping the balance

(2011) Katharina Eisenächer et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Targeting TLR4 Signaling by TLR4 Toll/IL-1 Receptor Domain-Derived Decoy Peptides: Identification of the TLR4 Toll/IL-1 Receptor Domain Dimerization Interface

(2011) V. Y. Toshchakov et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin

(2011) Kaifeng Zhou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

(2011) E. Valkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Toll-like receptors and innate immunity

(2009) Himanshu Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The TIR/BB-loop mimetic AS-1 protects the myocardium from ischaemia/reperfusion injury

(2009) Z. Cao et al.   CARDIOVASCULAR RESEARCH

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

Regulatory T cells and Toll-like receptors: What is the missing link?

(2009) Jie Dai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Identification of Critical Residues of the MyD88 Death Domain Involved in the Recruitment of Downstream Kinases

(2009) Maria Loiarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Immune Adaptor Molecule SARM Modulates Tumor Necrosis Factor Alpha Production and Microglia Activation in the Brainstem and Restricts West Nile Virus Pathogenesis

(2009) K. J. Szretter et al.   JOURNAL OF VIROLOGY

Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer

(2009) L. A. J. O'Neill et al.   PHARMACOLOGICAL REVIEWS

Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling

(2009) H. Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling

(2009) Fan Li et al.   PLoS Computational Biology

TLRs and innate immunity

(2008) B. A. Beutler   BLOOD

Structures of the Toll-like Receptor Family and Its Ligand Complexes

(2008) Mi Sun Jin et al.   IMMUNITY

The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer

(2008) Tomas Nyman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, Synthesis, and In Vitro Activity of Peptidomimetic Inhibitors of Myeloid Differentiation Factor 88

(2008) Nicola Fantò et al.   JOURNAL OF MEDICINAL CHEMISTRY

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

(2008) You-Me Kim et al.   NATURE

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE

Toll-like receptors: novel pharmacological targets for the treatment of neurological diseases

(2007) B MARSH et al.   CURRENT OPINION IN PHARMACOLOGY