Targeting the Redox Balance in Inflammatory Skin Conditions

Updates on chemical and biological research on botanical ingredients in dietary supplements

(2013) Rahul S. Pawar et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Thioredoxins, Glutaredoxins, and Peroxiredoxins—Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling

(2013) Eva-Maria Hanschmann et al.   ANTIOXIDANTS & REDOX SIGNALING

Cysteine Oxidative Posttranslational Modifications

(2013) Heaseung S. Chung et al.   CIRCULATION RESEARCH

Heme Oxygenase-1 and Breast Cancer Resistance Protein Protect Against Hemeinduced Toxicity

(2013) Frank A.D.T.G. Wagener et al.   CURRENT PHARMACEUTICAL DESIGN

Psoriasis Epidemiology: The Interplay of Genes and the Environment

(2013) Monica Enamandram et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Trolox-Sensitive Reactive Oxygen Species Regulate Mitochondrial Morphology, Oxidative Phosphorylation and Cytosolic Calcium Handling in Healthy Cells

(2012) Felix Distelmaier et al.   ANTIOXIDANTS & REDOX SIGNALING

Superoxide Dismutase 3 Controls Adaptive Immune Responses and Contributes to the Inhibition of Ovalbumin-Induced Allergic Airway Inflammation in Mice

(2012) Myung-Ja Kwon et al.   ANTIOXIDANTS & REDOX SIGNALING

Potential Therapeutic Effects of Natural Heme Oxygenase-1 Inducers in Cardiovascular Diseases

(2012) Ignazio Barbagallo et al.   ANTIOXIDANTS & REDOX SIGNALING

S-Nitrosylation: Specificity, Occupancy, and Interaction with Other Post-Translational Modifications

(2012) Alicia M. Evangelista et al.   ANTIOXIDANTS & REDOX SIGNALING

Functions, applications and production of 2-O-d-glucopyranosyl-l-ascorbic acid

(2012) Ruizhi Han et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Increased Risk of Diabetes Mellitus and Likelihood of Receiving Diabetes Mellitus Treatment in Patients With Psoriasis

(2012) Rahat S. Azfar et al.   ARCHIVES OF DERMATOLOGY

The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

(2012) Sebastian Altenhöfer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Specific inflammasomes in complex diseases

(2012) Seth L. Masters   CLINICAL IMMUNOLOGY

The Heme-Heme Oxygenase System in Wound Healing; Implications for Scar Formation

(2012) Frank A.D.T.G. Wagener et al.   CURRENT DRUG TARGETS

S-Glutathionylation signaling in cell biology: Progress and prospects

(2012) Anna Pastore et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Reactive oxygen and nitrogen species in pulmonary hypertension

(2012) Diana M. Tabima et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Glucose-6-phosphate dehydrogenase, NADPH, and cell survival

(2012) Robert C. Stanton   IUBMB LIFE

Reactive Oxygen Species in Health and Disease

(2012) Assim A. Alfadda et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Mitochondrial redox signalling at a glance

(2012) Yvonne Collins et al.   JOURNAL OF CELL SCIENCE

Impact of reactive oxygen species on keratinocyte signaling pathways

(2012) Toshinori Bito et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Loss of Extracellular Superoxide Dismutase Induces Severe IL-23-Mediated Skin Inflammation in Mice

(2012) Yun Sang Lee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Synthetic Superoxide Dismutase/Catalase Mimetic EUK-207 Mitigates Radiation Dermatitis and Promotes Wound Healing in Irradiated Rat Skin

(2012) Susan R. Doctrow et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Do Dietary Supplements Have Beneficial Health Effects in Industrialized Nations

(2012) Paul E. Marik et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Sun Exposure Behavior and Protection: Recommendations for Travelers

(2012) James H. Diaz et al.   JOURNAL OF TRAVEL MEDICINE

Cellular transport and homeostasis of essential and nonessential metals

(2012) Ebany J. Martinez-Finley et al.   Metallomics

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Iron Overload in Human Disease

(2012) Robert E. Fleming et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prednisone, Azathioprine, andN-Acetylcysteine for Pulmonary Fibrosis

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Inflammasome Activation of IL-1 Family Mediators in Response to Cutaneous Photodamage†

(2012) Tahseen H. Nasti et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics

(2012) S. Marrache et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficacy of inhaled N-acetylcysteine monotherapy in patients with early stage idiopathic pulmonary fibrosis

(2012) SAKAE HOMMA et al.   RESPIROLOGY

Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription

(2012) A.-B. Al-Mehdi et al.   Science Signaling

Modulating Mitochondrial Intracellular Location as a Redox Signal

(2012) M. P. Murphy   Science Signaling

Interleukin-1, inflammasomes, autoinflammation and the skin

(2012) E Contassot et al.   SWISS MEDICAL WEEKLY

Mitochondrial oxidative stress and the metabolic syndrome

(2012) Andrew M. James et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondrial proticity and ROS signaling: lessons from the uncoupling proteins

(2012) Ryan J. Mailloux et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Nitric oxide synthase uncoupling: A therapeutic target in cardiovascular diseases

(2012) Nathan D. Roe et al.   VASCULAR PHARMACOLOGY

Psoriasis and the Risk of Diabetes Mellitus

(2012) April W. Armstrong et al.   JAMA Dermatology

Physiological Antioxidative Network of the Bilirubin System in Aging and Age-Related Diseases

(2012) Sung Young Kim et al.   Frontiers in Pharmacology

Heme Cytotoxicity and the Pathogenesis of Immune-Mediated Inflammatory Diseases

(2012) Rasmus Larsen et al.   Frontiers in Pharmacology

Heme Oxygenase, Inflammation, and Fibrosis: The Good, the Bad, and the Ugly?

(2012) Ditte M. S. Lundvig et al.   Frontiers in Pharmacology

Role of haeme oxygenase-1 in resolution of oxidative stress-related pathologies: focus on cardiovascular, lung, neurological and kidney disorders

(2011) D. D. Haines et al.   Acta Physiologica

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

Psoriasis increased the risk of diabetes: a meta-analysis

(2011) Juan Cheng et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Dietary Supplements and Mortality Rate in Older Women

(2011) Jaakko Mursu   ARCHIVES OF INTERNAL MEDICINE

The O2 reduction and proton pumping gate mechanism of bovine heart cytochrome c oxidase

(2011) Shinya Yoshikawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Biochemical rationale and experimental data on the antiaging properties of CoQ10 at skin level

(2011) Thomas Blatt et al.   BIOFACTORS

Unraveling the Biological Roles of Reactive Oxygen Species

(2011) Michael P. Murphy et al.   Cell Metabolism

Molecular Mechanism of Glyceraldehyde-3-phosphate Dehydrogenase Inactivation by α,β-Unsaturated Carbonyl Derivatives

(2011) Christopher J. Martyniuk et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Mitochondrial Transporter ATP Binding Cassette Mitochondrial Erythroid Is a Novel Gene Required for Cardiac Recovery After Ischemia/Reperfusion

(2011) Marc Liesa et al.   CIRCULATION

Haem oxygenase-1: non-canonical roles in physiology and pathology

(2011) Anna Grochot-Przeczek et al.   CLINICAL SCIENCE

Xanthine oxidoreductase: A journey from purine metabolism to cardiovascular excitation-contraction coupling

(2011) Amit Agarwal et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Importance of Iron Chelation in Free Radical-Induced Oxidative Stress and Human Disease

(2011) Klaudia Jomova et al.   CURRENT PHARMACEUTICAL DESIGN

Regulation of skin inflammation and angiogenesis by EC-SOD via HIF-1α and NF-κB pathways

(2011) Younghwa Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Signalling pathways from NADPH oxidase-4 to idiopathic pulmonary fibrosis

(2011) Bruno Crestani et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitigation of radiation-induced lung injury by genistein and EUK-207

(2011) Javed Mahmood et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Regulation of protein tyrosine phosphatases by reversible oxidation

(2011) Arne Östman et al.   JOURNAL OF BIOCHEMISTRY

Translocation of Heme Oxygenase-1 to Mitochondria Is a Novel Cytoprotective Mechanism against Non-steroidal Anti-inflammatory Drug-induced Mitochondrial Oxidative Stress, Apoptosis, and Gastric Mucosal Injury

(2011) Samik Bindu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

(2011) Ina Takac et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Angiogenesis and oxidative stress: Common mechanisms linking psoriasis with atherosclerosis

(2011) April W. Armstrong et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Redox modification of cell signaling in the cardiovascular system

(2011) Dan Shao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

NADPH Oxidase-Mediated Redox Signaling: Roles in Cellular Stress Response, Stress Tolerance, and Tissue Repair

(2011) F. Jiang et al.   PHARMACOLOGICAL REVIEWS

Iron, oxidative stress and the example of solar ultraviolet A radiation

(2011) Asma Aroun et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Advances in metal-induced oxidative stress and human disease

(2011) Klaudia Jomova et al.   TOXICOLOGY

Redox Control of Protein–DNA Interactions: From Molecular Mechanisms to Significance in Signal Transduction, Gene Expression, and DNA Replication

(2010) Joseph Shlomai   ANTIOXIDANTS & REDOX SIGNALING

Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential

(2010) Ines Batinić-Haberle et al.   ANTIOXIDANTS & REDOX SIGNALING

Cysteine-Based Redox Switches in Enzymes

(2010) Chananat Klomsiri et al.   ANTIOXIDANTS & REDOX SIGNALING

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

(2010) Douglas B. Kell   ARCHIVES OF TOXICOLOGY

The Bilirubin-Increasing Drug Atazanavir Improves Endothelial Function in Patients With Type 2 Diabetes Mellitus

(2010) Douwe Dekker et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

S -Nitrosylation in Cardiovascular Signaling

(2010) Brian Lima et al.   CIRCULATION RESEARCH

Interleukin-1, inflammasomes and the skin

(2010) Laurence Feldmeyer et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The biliverdin–bilirubin antioxidant cycle of cellular protection: Missing a wheel?

(2010) Antony F. McDonagh   FREE RADICAL BIOLOGY AND MEDICINE

The IL-12p70/IL-10 interplay is differentially regulated by free heme and hemozoin in murine bone-marrow-derived macrophages

(2010) Mathieu Cambos et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Robust erythrophagocytosis leads to macrophage apoptosis via a hemin-mediated redox imbalance: role in hemolytic disorders

(2010) Mathieu Cambos et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Human Heme Oxygenase-1 Deficiency Presenting With Hemolysis, Nephritis, and Asplenia

(2010) Nita Radhakrishnan et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Hypoxia-inducible Factor-1 Activation in Nonhypoxic Conditions: The Essential Role of Mitochondrial-derived Reactive Oxygen Species

(2010) David A. Patten et al.   MOLECULAR BIOLOGY OF THE CELL

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

PROTECTION AGAINST ULTRAVIOLET-B RADIATION-INDUCED LOCAL and SYSTEMIC SUPPRESSION OF CONTACT HYPERSENSITIVITY and EDEMA RESPONSES IN C3H/HeN MICE BY GREEN TEA POLYPHENOLS

(2010) Santosh K. Katiyar et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Interleukin-1 (IL-1) Pathway

(2010) A. Weber et al.   Science Signaling

A Reaction-Diffusion Model of ROS-Induced ROS Release in a Mitochondrial Network

(2010) Lufang Zhou et al.   PLoS Computational Biology

Orchestrating Redox Signaling Networks through Regulatory Cysteine Switches

(2009) Candice E. Paulsen et al.   ACS Chemical Biology

Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH

(2009) Sabrina Serpillon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Small-Molecule NOX Inhibitors: ROS-Generating NADPH Oxidases as Therapeutic Targets

(2009) Vincent Jaquet et al.   ANTIOXIDANTS & REDOX SIGNALING

The UV response of the skin: a review of the MAPK, NFκB and TNFα signal transduction pathways

(2009) Visalini Muthusamy et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms

(2009) Joi A. Nichols et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Redox Regulation of SH2-Domain-Containing Protein Tyrosine Phosphatases by Two Backdoor Cysteines

(2009) Cheng-Yu Chen et al.   BIOCHEMISTRY

Aging skin is functionally anaerobic: Importance of coenzyme Q10for anti aging skin care

(2009) S. Prahl et al.   BIOFACTORS

A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding

(2009) Nathan R. Perron et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Molecular pathophysiology of psoriasis and molecular targets of antipsoriatic therapy

(2009) Emőke Rácz et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Nox proteins in signal transduction

(2009) David I. Brown et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress in the pathogenesis of psoriasis

(2009) Qiang Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Heme Oxygenase and Carbon Monoxide: Medicine Chemistry and Biological Effects Guest Editor: Yuji Naito Heme Oxygenase-1 is an Essential Cytoprotective Component in Oxidative Tissue Injury Induced by Hemorrhagic Shock

(2009) Toru Takahashi et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Protein denitrosylation: enzymatic mechanisms and cellular functions

(2009) Moran Benhar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Insulin resistance is a cellular antioxidant defense mechanism

(2009) K. L. Hoehn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bilirubin and glutathione have complementary antioxidant and cytoprotective roles

(2009) T. W. Sedlak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antioxidants prevent health-promoting effects of physical exercise in humans

(2009) M. Ristow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme oxygenase-1: from biology to therapeutic potential

(2009) Miguel P. Soares et al.   TRENDS IN MOLECULAR MEDICINE

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Radical-free biology of oxidative stress

(2008) Dean P. Jones   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Reactive Oxygen Species Regulate Neutrophil Recruitment and Survival in Pneumococcal Pneumonia

(2008) Helen M. Marriott et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal

(2008) Henry Jay Forman et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Catalase and glutathione peroxidase mimics

(2008) Brian J. Day   BIOCHEMICAL PHARMACOLOGY

Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy

(2008) Masuko Ushio-Fukai et al.   CANCER LETTERS

Molecular regulation of inflammation and cell death

(2008) Garabet Yeretssian et al.   CYTOKINE

Thiol chemistry and specificity in redox signaling

(2008) Christine C. Winterbourn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genetic deficiency of NADPH oxidase does not diminish, but rather enhances, LPS-induced acute inflammatory responses in vivo

(2008) Wei-Jian Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Decreasing Intracellular Superoxide Corrects Defective Ischemia-induced New Vessel Formation in Diabetic Mice

(2008) Daniel J. Ceradini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective Effects of Mitochondria-Targeted Antioxidant SkQ in Aqueous and Lipid Membrane Environments

(2008) Y. N. Antonenko et al.   JOURNAL OF MEMBRANE BIOLOGY

Reconciling the chemistry and biology of reactive oxygen species

(2008) Christine C Winterbourn   Nature Chemical Biology

Prevention of cognitive deficits and brain oxidative stress with superoxide dismutase/catalase mimetics in aged mice

(2008) Aaron Clausen et al.   NEUROBIOLOGY OF AGING

Pharmacological and Clinical Aspects of Heme Oxygenase

(2008) N. G. Abraham et al.   PHARMACOLOGICAL REVIEWS

The peroxidase-cyclooxygenase superfamily: Reconstructed evolution of critical enzymes of the innate immune system

(2008) Marcel Zamocky et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Regulated Protein Denitrosylation by Cytosolic and Mitochondrial Thioredoxins

(2008) M. Benhar et al.   SCIENCE

NOX enzymes as novel targets for drug development

(2008) J. David Lambeth et al.   Seminars in Immunopathology

NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

(2007) Weihai Ying   ANTIOXIDANTS & REDOX SIGNALING

Antipsoriatic effects of avarol-3′-thiosalicylate are mediated by inhibition of TNF-α generation and NF-κB activation in mouse skin

(2007) M Amigó et al.   BRITISH JOURNAL OF PHARMACOLOGY

Evaluation of survivin and NF-κB in psoriasis, an immunohistochemical study

(2007) Asmaa Gaber Abdou et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Extracellular superoxide dismutase (ecSOD) in vascular biology: an update on exogenous gene transfer and endogenous regulators of ecSOD

(2007) Zhenyu Qin et al.   Translational Research

Molecular, physiological and clinical aspects of the iron storage protein ferritin

(2007) Koichi Orino et al.   VETERINARY JOURNAL