Renin-Angiotensin System: An Old Player with Novel Functions in Skeletal Muscle

Angiotensin-(1–7) decreases skeletal muscle atrophy induced by angiotensin II through a Mas receptor-dependent mechanism

(2015) Franco Cisternas et al.   CLINICAL SCIENCE

Chronic oral administration of Ang-(1–7) improves skeletal muscle, autonomic and locomotor phenotypes in muscular dystrophy

(2014) Rasna Sabharwal et al.   CLINICAL SCIENCE

The Ang-(1–7)/Mas-1 axis attenuates the expression and signalling of TGF-β1 induced by AngII in mouse skeletal muscle

(2014) María Gabriela Morales et al.   CLINICAL SCIENCE

Expression of the Mas receptor is upregulated in skeletal muscle wasting

(2014) María Gabriela Morales et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Angiotensin Type 2 Receptor Signaling in Satellite Cells Potentiates Skeletal Muscle Regeneration

(2014) Tadashi Yoshida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The angiotensin-(1–7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice

(2014) Carla Meneses et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

ACE2 Is Augmented in Dystrophic Skeletal Muscle and Plays a Role in Decreasing Associated Fibrosis

(2014) Cecilia Riquelme et al.   PLoS One

Inflammation in Muscle Repair, Aging, and Myopathies

(2014) Marina Bouché et al.   Biomed Research International

Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis

(2014) Daniel Cabrera et al.   Skeletal Muscle

Transforming growth factor type beta 1 increases the expression of angiotensin II receptor type 2 by a SMAD- and p38 MAPK-dependent mechanism in skeletal muscle

(2013) Paula Painemal et al.   BIOFACTORS

Angiotensin (1–7) counteracts the negative effect of angiotensin II on insulin signalling in HUVECs

(2013) Eliezer Joseph Tassone et al.   CARDIOVASCULAR RESEARCH

Inhibition of the angiotensin-converting enzyme decreases skeletal muscle fibrosis in dystrophic mice by a diminution in the expression and activity of connective tissue growth factor (CTGF/CCN-2)

(2013) María Gabriela Morales et al.   CELL AND TISSUE RESEARCH

Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans

(2013) Felipe Simon et al.   CELLULAR SIGNALLING

Recent Progress in Molecular Mechanisms of Angiotensin II Type 1 and 2 Receptors

(2013) Shin-ichiro Miura et al.   CURRENT PHARMACEUTICAL DESIGN

Heat Shock Prevents Insulin Resistance-Induced Vascular Complications by Augmenting Angiotensin-(1-7) Signaling

(2013) P. A. Karpe et al.   DIABETES

The angiotensin converting enzyme insertion/deletion polymorphism alters the response of muscle energy supply lines to exercise

(2013) David Vaughan et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Role of proteoglycans in the regulation of the skeletal muscle fibrotic response

(2013) Enrique Brandan et al.   FEBS Journal

Activation of the Mas Receptor by Angiotensin-(1–7) in the Renin–Angiotensin System Mediates Mesenteric Vasodilatation in Cirrhosis

(2013) Josephine A. Grace et al.   GASTROENTEROLOGY

Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-β signalling

(2013) María José Acuña et al.   HUMAN MOLECULAR GENETICS

Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy

(2013) Maria Gabriela Morales et al.   HUMAN MOLECULAR GENETICS

Angiotensin-Converting Enzyme 2 Activation Improves Endothelial Function

(2013) Rodrigo A. Fraga-Silva et al.   HYPERTENSION

Angiotensin II Inhibits Satellite Cell Proliferation and Prevents Skeletal Muscle Regeneration

(2013) Tadashi Yoshida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Use of an Antifibrotic Agent Improves the Effect of Platelet-Rich Plasma on Muscle Healing After Injury

(2013) Satoshi Terada et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Prolonged treatment with angiotensin 1–7 improves endothelial function in diet-induced obesity

(2013) Andreas M. Beyer et al.   JOURNAL OF HYPERTENSION

Protein carbonylation and muscle function in COPD and other conditions

(2013) Esther Barreiro   MASS SPECTROMETRY REVIEWS

Cardiac and Respiratory Dysfunction in Duchenne Muscular Dystrophy and the Role of Second Messengers

(2013) Matias Mosqueira et al.   MEDICINAL RESEARCH REVIEWS

Angiotensin 1–7 improves insulin sensitivity by increasing skeletal muscle glucose uptake in vivo

(2013) Omar Echeverría-Rodríguez et al.   PEPTIDES

Disruption of muscle renin-angiotensin system in AT1a−/− mice enhances muscle function despite reducing muscle mass but compromises repair after injury

(2012) Kate T. Murphy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

ANG-(1–7) reduces ANG II-induced insulin resistance by enhancing Akt phosphorylation via a Mas receptor-dependent mechanism in rat skeletal muscle

(2012) Mujalin Prasannarong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biological approaches to improve skeletal muscle healing after injury and disease

(2012) Burhan Gharaibeh et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice

(2012) Asuka Shiota et al.   Cardiovascular Diabetology

Losartan Improves Adipose Tissue-Derived Stem Cell Niche by Inhibiting Transforming Growth Factor-β and Fibrosis in Skeletal Muscle Injury

(2012) Jin-Kyu Park et al.   CELL TRANSPLANTATION

Renin–angiotensin system blockade: a novel therapeutic approach in chronic obstructive pulmonary disease

(2012) Dinesh Shrikrishna et al.   CLINICAL SCIENCE

Angiotensin-(1–7): beyond the cardio-renal actions

(2012) Danielle G. Passos-Silva et al.   CLINICAL SCIENCE

TGFβ signaling

(2012) Elizabeth M. MacDonald et al.   CURRENT OPINION IN RHEUMATOLOGY

Role of Renin-Angiotensin System in Inflammation, Immunity and Aging

(2012) Luciano S.A. Capettini et al.   CURRENT PHARMACEUTICAL DESIGN

Angiotensin II: Role in Skeletal Muscle Atrophy

(2012) Claudio Cabello-Verrugio et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Loss of ACE2 Exaggerates High-Calorie Diet–Induced Insulin Resistance by Reduction of GLUT4 in Mice

(2012) Masao Takeda et al.   DIABETES

Activation of the ACE2/Angiotensin-(1-7)/Mas Receptor Axis Enhances the Reparative Function of Dysfunctional Diabetic Endothelial Progenitors

(2012) Y. P. R. Jarajapu et al.   DIABETES

Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrix-associated fibrin-driven inflammation coupled to the αMβ2 leukocyte integrin receptor

(2012) Berta Vidal et al.   HUMAN MOLECULAR GENETICS

Angiotensin II-induced pro-fibrotic effects require p38MAPK activity and transforming growth factor beta 1 expression in skeletal muscle cells

(2012) María Gabriela Morales et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The timing of administration of a clinically relevant dose of losartan influences the healing process after contusion induced muscle injury

(2012) Tetsuo Kobayashi et al.   JOURNAL OF APPLIED PHYSIOLOGY

Angiotensin-converting enzyme 2, angiotensin-(1–7) and Mas: new players of the renin–angiotensin system

(2012) Robson A S Santos et al.   JOURNAL OF ENDOCRINOLOGY

New therapeutic pathways in the RAS

(2012) Michael Bader et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

The role of the renin-angiotensin system in the development of insulin resistance in skeletal muscle

(2012) Erik J. Henriksen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Relationship between Human Aging Muscle and Oxidative System Pathway

(2012) Enrico Doria et al.   Oxidative Medicine and Cellular Longevity

ACE2 Deficiency Enhances Angiotensin II-Mediated Aortic Profilin-1 Expression, Inflammation and Peroxynitrite Production

(2012) Hai-Yan Jin et al.   PLoS One

The Mas receptor mediates modulation of insulin signaling by angiotensin-(1–7)

(2012) Marina C. Muñoz et al.   REGULATORY PEPTIDES

Contribution of the serine kinase c-Jun N-terminal kinase (JNK) to oxidant-induced insulin resistance in isolated rat skeletal muscle

(2012) Fernando R. Santos et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-α2-deficient congenital muscular dystrophy (MDC1A)

(2012) Sarina Meinen et al.   Skeletal Muscle

Regulation of angiotensin-(1–7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure

(2011) Wen-na Zong et al.   ACTA PHARMACOLOGICA SINICA

Acute and chronic angiotensin-(1–7) restores vasodilation and reduces oxidative stress in mesenteric arteries of salt-fed rats

(2011) Gábor Raffai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Chronic renin inhibition with aliskiren improves glucose tolerance, insulin sensitivity, and skeletal muscle glucose transport activity in obese Zucker rats

(2011) Elizabeth M. Marchionne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Losartan, a therapeutic candidate in congenital muscular dystrophy: Studies in the dy2J/dy2J Mouse

(2011) Moran Elbaz et al.   ANNALS OF NEUROLOGY

Angiotensin II induced catabolic effect and muscle atrophy are redox dependent

(2011) Laura C. Semprun-Prieto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fibrotic response induced by angiotensin-II requires NAD(P)H oxidase-induced reactive oxygen species (ROS) in skeletal muscle cells

(2011) Claudio Cabello-Verrugio et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Losartan Enhances the Success of Myoblast Transplantation

(2011) Raouia Fakhfakh et al.   CELL TRANSPLANTATION

Roles of Interleukin 17 in Angiotensin II Type 1 Receptor–Mediated Insulin Resistance

(2011) Kousei Ohshima et al.   HYPERTENSION

Losartan Decreases Cardiac Muscle Fibrosis and Improves Cardiac Function in Dystrophin-Deficient Mdx Mice

(2011) Christopher F. Spurney et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Angiotensin II receptor type 1 blockade decreases CTGF/CCN2-mediated damage and fibrosis in normal and dystrophic skeletal muscles

(2011) Claudio Cabello-Verrugio et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

CTGF/CCN-2 over-expression can directly induce features of skeletal muscle dystrophy

(2011) María Gabriela Morales et al.   JOURNAL OF PATHOLOGY

Effects of angiotensin II AT1 receptor inhibition and exercise training on insulin action in rats on high-fat diet

(2011) Zhonghua Wang et al.   LIFE SCIENCES

Enalapril treatment discloses an early role of angiotensin II in inflammation- and oxidative stress-related muscle damage in dystrophic mdx mice

(2011) Anna Cozzoli et al.   PHARMACOLOGICAL RESEARCH

Losartan Restores Skeletal Muscle Remodeling and Protects Against Disuse Atrophy in Sarcopenia

(2011) T. N. Burks et al.   Science Translational Medicine

The ACE Gene and Human Performance

(2011) Zudin Puthucheary et al.   SPORTS MEDICINE

Aberrant repair and fibrosis development in skeletal muscle

(2011) Christopher J Mann et al.   Skeletal Muscle

Angiotensin-Converting Enzyme 2: The First Decade

(2011) Nicola E. Clarke et al.   International Journal of Hypertension

IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and Foxo-dependent inhibition of the ubiquitin ligase atrogin-1 expression

(2010) Tadashi Yoshida et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Stem Cell Therapies to Treat Muscular Dystrophy

(2010) Mirella Meregalli et al.   BIODRUGS

Characterization of angiotensin-converting enzymes 1 and 2 in the soleus and plantaris muscles of rats

(2010) T. Fernandes et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?

(2010) E. M. V. de Cavanagh et al.   CARDIOVASCULAR RESEARCH

Angiotensin I-Converting Enzyme Type 2 (ACE2) Gene Therapy Improves Glycemic Control in Diabetic Mice

(2010) S. M. Bindom et al.   DIABETES

Angiotensin II revisited: new roles in inflammation, immunology and aging

(2010) Ariela Benigni et al.   EMBO Molecular Medicine

Irbesartan enhances GLUT4 translocation and glucose transport in skeletal muscle cells

(2010) Tatsuo Kobayashi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Regulation and dysregulation of fibrosis in skeletal muscle

(2010) Antonio L. Serrano et al.   EXPERIMENTAL CELL RESEARCH

Oxidative stress and the etiology of insulin resistance and type 2 diabetes

(2010) Erik J. Henriksen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Loss of ACE2 accelerates time-dependent glomerular and tubulointerstitial damage in streptozotocin-induced diabetic mice

(2010) Atsushi Shiota et al.   HYPERTENSION RESEARCH

Anti-Inflammatory Effects of the Activation of the Angiotensin-(1-7) Receptor, Mas, in Experimental Models of Arthritis

(2010) K. D. da Silveira et al.   JOURNAL OF IMMUNOLOGY

Satellite Cell Dysfunction and Impaired IGF-1 Signaling Cause CKD-Induced Muscle Atrophy

(2010) L. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Skeletal muscle myoblasts possess a stretch-responsive local angiotensin signalling system

(2010) Adam P W Johnston et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis

(2010) Hideaki Kaneto et al.   MEDIATORS OF INFLAMMATION

Angiotensin II Inhibits Insulin-Stimulated GLUT4 Translocation and Akt Activation through Tyrosine Nitration-Dependent Mechanisms

(2010) Alfredo Csibi et al.   PLoS One

Regulation of Muscle Satellite Cell Activation and Chemotaxis by Angiotensin II

(2010) Adam P. W. Johnston et al.   PLoS One

Angiotensin-(1-7) stimulates the phosphorylation of Akt in rat extracardiac tissues in vivo via receptor Mas

(2010) Marina C. Muñoz et al.   REGULATORY PEPTIDES

Direct inhibition by angiotensin II of insulin-dependent glucose transport activity in mammalian skeletal muscle involves a ROS-dependent mechanism

(2010) Maggie K. Diamond-Stanic et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting

(2009) J. M. McClung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Developmentally spliced PKCβII provides a possible link between mTORC2 and Akt kinase to regulate 3T3-L1 adipocyte insulin-stimulated glucose transport

(2009) E. Kleiman et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reduction in renal ACE2 expression in subtotal nephrectomy in rats is ameliorated with ACE inhibition

(2009) Elena Velkoska et al.   CLINICAL SCIENCE

Direct Renin Inhibition Improves Systemic Insulin Resistance and Skeletal Muscle Glucose Transport in a Transgenic Rodent Model of Tissue Renin Overexpression

(2009) Guido Lastra et al.   ENDOCRINOLOGY

Oxidant stress-induced loss of IRS-1 and IRS-2 proteins in rat skeletal muscle: Role of p38 MAPK

(2009) Tara L. Archuleta et al.   FREE RADICAL BIOLOGY AND MEDICINE

Devil and angel in the renin–angiotensin system: ACE–angiotensin II–AT1 receptor axis vs. ACE2–angiotensin-(1–7)–Mas receptor axis

(2009) Masaru Iwai et al.   HYPERTENSION RESEARCH

Decreased muscle ACE activity enhances functional response to endurance training in rats, without change in muscle oxidative capacity or contractile phenotype

(2009) Estelle Habouzit et al.   JOURNAL OF APPLIED PHYSIOLOGY

IL-6 and Serum Amyloid A Synergy Mediates Angiotensin II-Induced Muscle Wasting

(2009) L. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Intramuscular renin–angiotensin system is activated in human muscular dystrophy

(2009) Guilian Sun et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Mechanisms of Cancer Cachexia

(2009) Michael J. Tisdale   PHYSIOLOGICAL REVIEWS

Renin-angiotensin system in the pathogenesis of liver fibrosis

(2009) Regina Maria Pereira et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Mechanism of attenuation of muscle protein degradation induced by tumor necrosis factor-α and angiotensin II by β-hydroxy-β-methylbutyrate

(2008) Helen L. Eley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Chronic infusion of angiotensin-(1–7) improves insulin resistance and hypertension induced by a high-fructose diet in rats

(2008) Jorge F. Giani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Angiotensin II and tumor necrosis factor-α synergistically promote monocyte chemoattractant protein-1 expression: roles of NF-κB, p38, and reactive oxygen species

(2008) Masao Takahashi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Angiotensin II Receptor Blockade Administered after Injury Improves Muscle Regeneration and Decreases Fibrosis in Normal Skeletal Muscle

(2008) Hany S. Bedair et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

(2008) Tsuneo Ikenoue et al.   EMBO JOURNAL

Renin–angiotensin system inhibitors protect against age-related changes in rat liver mitochondrial DNA content and gene expression

(2008) Elena M.V. de Cavanagh et al.   EXPERIMENTAL GERONTOLOGY

Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis

(2008) Robson A. S. Santos et al.   EXPERIMENTAL PHYSIOLOGY

Transgenic Angiotensin-Converting Enzyme 2 Overexpression in Vessels of SHRSP Rats Reduces Blood Pressure and Improves Endothelial Function

(2008) Brit Rentzsch et al.   HYPERTENSION

Endothelial Dysfunction and Elevated Blood Pressure in Mas Gene-Deleted Mice

(2008) Ping Xu et al.   HYPERTENSION

Effects of Antihypertensive Drugs and Exercise Training on Insulin Sensitivity in Spontaneously Hypertensive Rats

(2008) Qi GUO et al.   HYPERTENSION RESEARCH

Ablation of angiotensin (1-7) receptor Mas in C57Bl/6 mice causes endothelial dysfunction

(2008) Luiza A. Rabelo et al.   Journal of the American Society of Hypertension

Novel regulatory mechanisms for the proteoglycans decorin and biglycan during muscle formation and muscular dystrophy

(2008) Enrique Brandan et al.   MATRIX BIOLOGY

The sweeter side of ACE2: Physiological evidence for a role in diabetes

(2008) Sharell M. Bindom et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Local RAS and inflammatory factors are involved in cardiovascular hypertrophy in spontaneously hypertensive rats

(2008) L LI et al.   PHARMACOLOGICAL RESEARCH

Angiotensin II-induced skeletal muscle insulin resistance mediated by NF-κB activation via NADPH oxidase

(2007) Yongzhong Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Genetically altered animal models for Mas and angiotensin-(1-7)

(2007) Natalia Alenina et al.   EXPERIMENTAL PHYSIOLOGY

Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation

(2007) Cecilia Vial et al.   JOURNAL OF CELLULAR PHYSIOLOGY