Cardiac and Respiratory Dysfunction in Duchenne Muscular Dystrophy and the Role of Second Messengers

Effects of Angiotensin-Converting Enzyme Inhibitors and/or Beta Blockers on the Cardiomyopathy in Duchenne Muscular Dystrophy

(2012) Laurence Viollet et al.   AMERICAN JOURNAL OF CARDIOLOGY

Long-Term Preservation of Cardiac Structure and Function After Adeno-Associated Virus Serotype 9-Mediated Microdystrophin Gene Transfer in mdx Mice

(2012) Stefanie Schinkel et al.   HUMAN GENE THERAPY

Nitric Oxide in Myogenesis and Therapeutic Muscle Repair

(2012) Clara De Palma et al.   MOLECULAR NEUROBIOLOGY

Comparison of skeletal muscle pathology and motor function of dystrophin and utrophin deficient mouse strains

(2012) Maaike van Putten et al.   NEUROMUSCULAR DISORDERS

Proteomic Analysis Reveals New Cardiac-Specific Dystrophin-Associated Proteins

(2012) Eric K. Johnson et al.   PLoS One

Long-Term Blocking of Calcium Channels in mdx Mice Results in Differential Effects on Heart and Skeletal Muscle

(2011) Louise H. Jørgensen et al.   AMERICAN JOURNAL OF PATHOLOGY

Restoring Dystrophin Expression in Duchenne Muscular Dystrophy Muscle

(2011) Eric P. Hoffman et al.   AMERICAN JOURNAL OF PATHOLOGY

Nitric oxide donors improve prednisone effects on muscular dystrophy in the mdx mouse diaphragm

(2011) Wataru Mizunoya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Stretch-activated calcium channel protein TRPC1 is correlated with the different degrees of the dystrophic phenotype in mdx mice

(2011) Cíntia Yuri Matsumura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Fibrotic response induced by angiotensin-II requires NAD(P)H oxidase-induced reactive oxygen species (ROS) in skeletal muscle cells

(2011) Claudio Cabello-Verrugio et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Membrane Sealant Poloxamer P188 Protects Against Isoproterenol Induced Cardiomyopathy in Dystrophin Deficient Mice

(2011) Christopher F Spurney et al.   BMC Cardiovascular Disorders

Early Treatment With Lisinopril and Spironolactone Preserves Cardiac and Skeletal Muscle in Duchenne Muscular Dystrophy Mice

(2011) Jill A. Rafael-Fortney et al.   CIRCULATION

Selective deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy

(2011) Hongqiang Cheng et al.   HUMAN MOLECULAR GENETICS

Losartan Decreases Cardiac Muscle Fibrosis and Improves Cardiac Function in Dystrophin-Deficient Mdx Mice

(2011) Christopher F. Spurney et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Angiotensin II receptor type 1 blockade decreases CTGF/CCN2-mediated damage and fibrosis in normal and dystrophic skeletal muscles

(2011) Claudio Cabello-Verrugio et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle

(2011) Sanjeewa A. Goonasekera et al.   JOURNAL OF CLINICAL INVESTIGATION

Ahnak1 is a tuneable modulator of cardiac Ca(v)1.2 calcium channel activity

(2011) Ines Pankonien et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

CTGF/CCN-2 over-expression can directly induce features of skeletal muscle dystrophy

(2011) María Gabriela Morales et al.   JOURNAL OF PATHOLOGY

Current Status of Pharmaceutical and Genetic Therapeutic Approaches to Treat DMD

(2011) Christophe Pichavant et al.   MOLECULAR THERAPY

Enalapril treatment discloses an early role of angiotensin II in inflammation- and oxidative stress-related muscle damage in dystrophic mdx mice

(2011) Anna Cozzoli et al.   PHARMACOLOGICAL RESEARCH

iNOS Ablation Does Not Improve Specific Force of the Extensor Digitorum Longus Muscle in Dystrophin-Deficient mdx4cv Mice

(2011) Dejia Li et al.   PLoS One

Voltage-Gated Ion Channel Dysfunction Precedes Cardiomyopathy Development in the Dystrophic Heart

(2011) Xaver Koenig et al.   PLoS One

X-ROS Signaling: Rapid Mechano-Chemo Transduction in Heart

(2011) B. L. Prosser et al.   SCIENCE

Therapeutic Potential of Proteasome Inhibition in Duchenne and Becker Muscular Dystrophies

(2010) Elisabetta Gazzerro et al.   AMERICAN JOURNAL OF PATHOLOGY

Upregulation of store-operated Ca2+ entry in dystrophic mdx mouse muscle

(2010) Joshua N. Edwards et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Stress-induced opening of the permeability transition pore in the dystrophin-deficient heart is attenuated by acute treatment with sildenafil

(2010) Alexis Ascah et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Microarchitecture Is Severely Compromised but Motor Protein Function Is Preserved in Dystrophic mdx Skeletal Muscle

(2010) O. Friedrich et al.   BIOPHYSICAL JOURNAL

Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice

(2010) Alessandra Sacco et al.   CELL

Potential Therapeutic Targets for Cardiac Fibrosis

(2010) Andrew Leask   CIRCULATION RESEARCH

Superior calcium homeostasis of extraocular muscles

(2010) Ulrike Zeiger et al.   EXPERIMENTAL EYE RESEARCH

Overexpression of SERCA1a in the mdx Diaphragm Reduces Susceptibility to Contraction-Induced Damage

(2010) Kevin J. Morine et al.   HUMAN GENE THERAPY

Diaphragm rescue alone prevents heart dysfunction in dystrophic mice

(2010) Alastair Crisp et al.   HUMAN MOLECULAR GENETICS

Duchenne muscular dystrophy – What causes the increased membrane permeability in skeletal muscle?

(2010) David G. Allen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Increased connective tissue growth factor associated with cardiac fibrosis in the mdx mouse model of dystrophic cardiomyopathy

(2010) Carol G. Au et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Golgi and sarcolemmal neuronal NOS differentially regulate contraction-induced fatigue and vasoconstriction in exercising mouse skeletal muscle

(2010) Justin M. Percival et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic administration of membrane sealant prevents severe cardiac injury and ventricular dilatation in dystrophic dogs

(2010) DeWayne Townsend et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting Fibrosis in Duchenne Muscular Dystrophy

(2010) Lan Zhou et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

One-year Treatment of Morpholino Antisense Oligomer Improves Skeletal and Cardiac Muscle Functions in Dystrophic mdx Mice

(2010) Bo Wu et al.   MOLECULAR THERAPY

Timeline of cardiac dystrophy in 3-18-month-old MDX mice

(2010) Christel Van Erp et al.   MUSCLE & NERVE

Dystrophin Immunity in Duchenne's Muscular Dystrophy

(2010) Jerry R. Mendell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ahnak1 modulates L-type Ca2+ channel inactivation of rodent cardiomyocytes

(2010) Julio L. Alvarez et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Functional TRPV4 channels are expressed in mouse skeletal muscle and can modulate resting Ca2+ influx and muscle fatigue

(2010) Bernd W. Pritschow et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Arginine Metabolism by Macrophages Promotes Cardiac and Muscle Fibrosis in mdx Muscular Dystrophy

(2010) Michelle Wehling-Henricks et al.   PLoS One

Our trails and trials in the subsarcolemmal cytoskeleton network and muscular dystrophy researches in the dystrophin era

(2010) Eijiro OZAWA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy

(2010) J. Fauconnier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy

(2010) C. M. Adamo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Human-Specific Deletion in Mouse Cmah Increases Disease Severity in the mdx Model of Duchenne Muscular Dystrophy

(2010) K. Chandrasekharan et al.   Science Translational Medicine

Exploring the caves: cavins, caveolins and caveolae

(2010) Carsten G. Hansen et al.   TRENDS IN CELL BIOLOGY

How Respiratory Muscle Strength Correlates with Cough Capacity in Patients with Respiratory Muscle Weakness

(2010) Jung Hyun Park et al.   YONSEI MEDICAL JOURNAL

Hypersensitivity of excitation-contraction coupling in dystrophic cardiomyocytes

(2009) Nina D. Ullrich et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Long-term improvement in mdx cardiomyopathy after therapy with peptide-conjugated morpholino oligomers†

(2009) Natee Jearawiriyapaisarn et al.   CARDIOVASCULAR RESEARCH

Pathways of abnormal stress-induced Ca2+ influx into dystrophic mdx cardiomyocytes

(2009) M. Fanchaouy et al.   CELL CALCIUM

Contrasting effects of steroids and angiotensin-converting-enzyme inhibitors in a mouse model of dystrophin-deficient cardiomyopathy

(2009) Ralf Bauer et al.   EUROPEAN JOURNAL OF HEART FAILURE

Abdominal volume contribution to tidal volume as an early indicator of respiratory impairment in Duchenne muscular dystrophy

(2009) A. Lo Mauro et al.   EUROPEAN RESPIRATORY JOURNAL

Regulation of TRPC1 and TRPC4 Cation Channels Requires an α1-Syntrophin-dependent Complex in Skeletal Mouse Myotubes

(2009) Jessica Sabourin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy

(2009) Yi Lai et al.   JOURNAL OF CLINICAL INVESTIGATION

Current understanding and management of dilated cardiomyopathy in Duchenne and Becker muscular dystrophy

(2009) Rita Wen Kaspar et al.   Journal of the American Academy of Nurse Practitioners

Intramuscular renin–angiotensin system is activated in human muscular dystrophy

(2009) Guilian Sun et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Sarcoplasmic-endoplasmic-reticulum Ca2+-ATPase and calsequestrin are overexpressed in spared intrinsic laryngeal muscles of dystrophin-deficientmdxmice

(2009) Renato Ferretti et al.   MUSCLE & NERVE

Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

(2009) Andrew M Bellinger et al.   NATURE MEDICINE

Reciprocal amplification of ROS and Ca2+ signals in stressed mdx dystrophic skeletal muscle fibers

(2009) Vyacheslav M. Shkryl et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism

(2009) Douglas P. Millay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connective tissue growth factor and cardiac fibrosis

(2008) A. Daniels et al.   Acta Physiologica

Mechanisms of Muscle Degeneration, Regeneration, and Repair in the Muscular Dystrophies

(2008) Gregory Q. Wallace et al.   Annual Review of Physiology

Cardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death

(2008) M. Zheng et al.   HUMAN MOLECULAR GENETICS

Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy

(2008) S. A. Villalta et al.   HUMAN MOLECULAR GENETICS

Dominant-negative inhibition of Ca2+ influx via TRPV2 ameliorates muscular dystrophy in animal models

(2008) Yuko Iwata et al.   HUMAN MOLECULAR GENETICS

Beneficial effects of beta-blockers and angiotensin-converting enzyme inhibitors in Duchenne muscular dystrophy

(2008) Hitoko Ogata et al.   Journal of Cardiology

Nav1.4 Deregulation in Dystrophic Skeletal Muscle Leads to Na+Overload and Enhanced Cell Death

(2008) Carole Hirn et al.   JOURNAL OF GENERAL PHYSIOLOGY

Abnormal cardiac morphology, function and energy metabolism in the dystrophic mdx mouse: An MRI and MRS study

(2008) Wen Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac Expression of a Mini-dystrophin That Normalizes Skeletal Muscle Force Only Partially Restores Heart Function in Aged Mdx Mice

(2008) Brian Bostick et al.   MOLECULAR THERAPY

STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle

(2008) Jonathan Stiber et al.   NATURE CELL BIOLOGY

Mdx respiratory impairment following fibrosis of the diaphragm

(2008) Masatoshi Ishizaki et al.   NEUROMUSCULAR DISORDERS

Transient receptor potential cation channels in normal and dystrophic mdx muscle

(2008) Jana Krüger et al.   NEUROMUSCULAR DISORDERS

L-Type Ca2+ Channel Function Is Linked to Dystrophin Expression in Mammalian Muscle

(2008) Oliver Friedrich et al.   PLoS One

Inhibitory Control Over Ca2+ Sparks via Mechanosensitive Channels Is Disrupted in Dystrophin Deficient Muscle but Restored by Mini-Dystrophin Expression

(2008) Martin D. H. Teichmann et al.   PLoS One

Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency

(2008) M. Khairallah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer

(2008) B. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevention of Dystrophin-Deficient Cardiomyopathy in Twenty-One-Month-Old Carrier Mice by Mosaic Dystrophin Expression or Complementary Dystrophin/Utrophin Expression

(2007) Brian Bostick et al.   CIRCULATION RESEARCH

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY

Reactive oxygen species contribute to Ca2+signals produced by osmotic stress in mouse skeletal muscle fibres

(2007) Adriano S. Martins et al.   JOURNAL OF PHYSIOLOGY-LONDON

Connective tissue growth factor is overexpressed in muscles of human muscular dystrophy

(2007) Guilian Sun et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Haploinsufficiency of utrophin gene worsens skeletal muscle inflammation and fibrosis in mdx mice

(2007) Lan Zhou et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES