Wai Lo

United States UConn

Hub

Commented on Ethical problems in academic peer review
To address these ethical issues, journals and academic institutions often have guidelines and codes of conduct in place, and transparency and open dialogue among all parties involved are crucial for maintaining the integrity of peer review.

Article

Commented on p25 protein is a modulator of gamma-cleavage through the mechanism common to TMP21
TMP21, from the p24 cargo-protein family, modulates gamma-secretase, which generates Aβ linked to Alzheimer's; while p24a lacks this function, the potential regulatory role of other p24 family members, such as p25, is yet to be explored.

Article

Commented on Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25
How does the overexpression or absence of calpastatin (CAST) influence the production of p25 and subsequently the deregulation of Cdk5, potentially impacting the onset of neurodegenerative diseases like Alzheimer's?

Article

Commented on CDK5 activator protein p25 preferentially binds and activates GSK3β
p25, but not p35, binds to GSK3β altering its activity and substrate specificity, suggesting that effects previously attributed to CDK5 hyperactivation might involve altered GSK3β activity, impacting Alzheimer’s treatment strategies.

Article

Commented on Self protein-protein interactions are involved in TPPP/p25 mediated microtubule bundling
TPPP/p25, linked to neurodegenerative diseases, has two microtubule binding sites in its disordered regions that contribute to its ability to stimulate and bundle microtubules. The central folded domain of TPPP/p25, once bound to microtubules, can induce protein interactions that result in bundled microtubules.

Article

Commented on CDK1, the Other ‘Master Regulator’ of Autophagy
Great review published in Trends series. During mitosis, autophagy initiation is repressed, but cap-dependent mRNA translation remains active, despite mTORC1 activity being suppressed. This regulation shift is primarily mediated by a transition from mTORC1 to cyclin-dependent kinase 1 (CDK1) control, resolving past controversies and providing a coherent model for understanding autophagy and mTORC1 during mitosis.

Article

Commented on Cohesin and Cdk1: an anaphase barricade
In metazoan cells, the separation of sister chromatids during anaphase involves cleaving the kleisin subunit of centromeric cohesin, while the effective movement of these separated sisters towards the poles necessitates a concurrent reduction in Cdk1 activity. This coordination of events is facilitated by the activation of the anaphase-promoting complex/cyclosome (APC/C).

Article

Commented on CDK1 makes the meiotic spindle wait
Interesting article published in JCB. Davydenko and colleagues found that delaying cyclin-dependent kinase CDK1 activity in oocytes further delayed the stabilization of kinetochore-microtubule attachments. Conversely, boosting CDK1 function prematurely led to earlier attachment stabilization and increased chromosome segregation errors, suggesting that oocytes employ this mechanism to prevent incorrect kinetochore-microtubule connections during meiosis.

Article

Commented on Cdk1 boosts mitochondrial energy production
The study revealed that cyclin B1/Cdk1 localizes to mitochondria and identified 12 mitochondrial proteins, including C1 complex subunits, as Cdk1 substrates. Furthermore, targeting cyclin B1/Cdk1 to mitochondria enhanced C1 activity and mitochondrial respiration, leading to cell cycle acceleration, particularly in the G1 phase, along with the expected peak in C1 activity at G2/M.

Article

Commented on Cell adhesion molecule 1 is a new osteoblastic cell adhesion molecule and a diagnostic marker for osteosarcoma
These paper indicated that CADM1 was a novel osteoblastic adhesion molecule that is expressed transiently during osteoblastic maturation, and a useful diagnostic marker for osteosarcoma cells.

Webinar

Commented on LuTan-1: An Innovative L-band Spaceborne Bistatic Interferimetric SAR Mission
Seems interesting talk. But the video is not available now, are they going to repost it?

Webinar

Commented on Demystifying AI and Its Generative Power
Interesting talk. It would be helpful to talk mora about the ethical issue.

Hub

Commented on Toxic Effects of Environmental Heavy Metals on Cardiovascular Pathophy
This is a book published by LAP LAMBERT Academic Publishing.

Hub

Commented on Nanoelectronic Materials Fundamentals and Applications
This book covers research in nanoelectronics, focusing on numerical calculations of electronic properties and quantum transport in nanoscale devices, discussing computational simulations, nanoelectronic materials, size effects, electronic characteristics, fabrication techniques, and functionality of nanomaterials.

Hub

Commented on Toxische Auswirkungen von Umweltschwermetallen auf Herz-Kreislauf-Erkrankungen Paperback German
Can someone translate the hub title in English? Thanks