Wai Lo

United States UConn

Funding

Commented on Crime as a service
@ Gorman: The rise of Crime-as-a-Service (CaaS) is concerning and poses significant challenges for law enforcement and cybersecurity efforts. With illegal activities like Ransomware-as-a-Service, DDoS-as-a-Service, and Phishing Kits being readily available on the dark web, both cybercriminals and conventional criminals can access and use these services, exacerbating the threat landscape. It underscores the importance of continued efforts to combat cybercrime and enhance online security measures.

Article

Commented on Microneedles in the clinic
Published in J Controlled Release, this review outlines the tremendous progress made in the field of microneedle technology, with research focusing on its potential in cosmetic and therapeutic applications. It underscores the importance of clinical studies in assessing the safety and efficacy of microneedle-based systems, covering various applications ranging from skin rejuvenation and hair growth to vaccinations and diabetes management.

Poster

Commented on Optimization of a VHH targeting Tau nucleation core and inhibiting Tau seeding
Yes, optimizing a VHH (single-domain antibody) to target Tau's nucleation core and inhibit Tau seeding represents an important step in advancing potential treatments for neurodegenerative diseases such as Alzheimer's. Could they elaborate on the specific factors that contribute to this stability, and how it might be further optimized to increase the efficacy of VHH Z70 in reducing tau aggregation?

Article

Commented on Microneedle, bio-microneedle and bio-inspired microneedle: A review
This review provides a comprehensive overview of the mechanical challenges related to microneedle (MN) usage, an increasingly important tool for minimally invasive drug delivery.

Article

Commented on Microneedle technology for potential SARS-CoV-2 vaccine delivery
The review article highlights the promising future of microneedle technology in vaccine delivery. Fueled by the SARS-CoV-2 pandemic, the development of this painless, user-friendly vaccination method is evolving.

Funding

Commented on Crime as a service
"Crime as a service" refers to the practice of offering criminal services or tools as a commercialized and easily accessible service on the internet. This includes hacking, malware distribution, selling stolen data, and even dark web.

Article

Commented on Electroceuticals for peripheral nerve regeneration
This review discusses the potential of electroceuticals for peripheral nerve regeneration, highlighting the challenges in delivering effective and controllable electroceuticals via bioelectronic implantable devices.

Article

Commented on Past, present and future of living systematic review: a bibliometrics analysis
Very useful article published in BMJ Global Health. The study provides a comprehensive review of Living Systematic Reviews (LSRs) up to October 2021 using bibliometrics. LSRs have gained significant attention, with a growing number of studies conducted since 2020, especially in Europe, North America, and Australia. COVID-19 is the predominant focus of LSRs, and potential future research directions include rehabilitation of COVID-19 patients and virological studies.

Article

Commented on 3D two-photon polymerization of smart cell gelatin – collagen matrixes with incorporated ruthenium complexes for the monitoring of local oxygen tensions
Researchers developed stable gelatin-collagen matrices using two-photon polymerization with incorporated ruthenium complexes as photo-activators. These matrices allowed continuous monitoring of local oxygen levels (pO2) at the pericellular level in 3D cell cultures. The study demonstrated the potential for analyzing cancer cell metabolic adaptations and migration in a more in vivo-like microenvironment, offering new therapeutic insights and drug screening platforms.

Article

Commented on Herbal medicine: the magic way crouching microbial resistance
This review article highlights nine highly effective and key herbs, with unique molecular mechanisms of action, to be used alongside antibiotics in overcoming the crisis of antibiotic resistance.

Article

Commented on Glucaric acids from Leonurus japonicus
These findings add valuable information to our understanding of the potential bioactive compounds present in Leonurus japonicus Houtt. They also shed light on how these compounds may influence hepatoprotection and cytotoxicity.

Webinar

Commented on GPT-3 & Beyond
Is it a older version? Now is GPT-4 and potentially more advanced versions as technology progresses.

Webinar

Commented on Visible Biology: A 3D Showcase
Interesting seminar. These interactive resources provide an excellent opportunity for educators to create engaging and interactive assignments for their students.

Webinar

Commented on Preparing medical imaging data for machine learning by Martin Willemink
For medical imaging, ensuring model accuracy and safety is of paramount significance, making thorough preparation and evaluation indispensable steps in the machine learning process.

Article

Commented on Kinesin-1 autoinhibition facilitates the initiation of dynein cargo transport
Published in JCB, the study demonstrated the functional significance of Kinesin-1 autoinhibition in dynein-mediated early endosome transport. Kinesin-1 autoinhibition facilitates dynein to initiate early endosome transport, independently of direct competition between dynein and kinesin-1, and is related to cargo adapter-mediated dynein activation beyond the switching of dynein from its autoinhibited conformation.