Wai Lo

United States UConn

Article

Commented on Estimation of microtubule-generated forces using a DNA origami nanospring
In this article published in JSC, researchers have developed an experimental method using fluorescent spring-shaped DNA origami molecules to estimate microtubule-generated forces and monitor the recruitment of proteins at the force generation site simultaneously, providing a valuable tool for studying these processes without the need for complex instrumentation, such as optical trapping. The validation of DNA nanosprings against optical trapping results further confirms their effectiveness in studying the coupling of protein activity with microtubule growth and shortening.

Article

Commented on Monkey pox: A public health emergency
It is a rare viral disease. It can be transmitted to humans from animals or from person to person through respiratory droplets, bodily fluids, or contact with infected materials.

Hub

Commented on Standardizing Journal Articles
Yes, the world would likely be a better place if there were more standardization for how researchers report their results and protocols in peer-reviewed journals.

Hub

Commented on Science & Policy Engagement Hub
Engaging in policy-related work offers a unique opportunity to contribute to positive change, foster inclusive decision-making processes, and make a lasting impact on society.

Hub

Commented on Intellectual Property Rights
Intellectual property plays a crucial role in fostering innovation, protecting the rights of creators and inventors, and promoting economic growth by encouraging the development and dissemination of new ideas and products.

Funding

Commented on DoD Tick-Borne Disease Research Program Idea Development Award
The most common tick-borne disease in the United States is Lyme disease.

Article

Commented on Ten simple rules for serving as an editor
My favorite ten simple rules paper published in PLoS, here is the new paper on how to serve as an editor, I have copied and pasted the 10 rules here: Rule 1: Only accept an invitation if you can do it—be dedicated to it, and ensure you can realistically prioritize it Rule 2: Draw upon your experiences to guide your decision-making as an editor—Look backward (on your own experiences), and look forward (with appreciation and respect) Rule 3: Be fair and objective in judging the work, and treat all parties respectfully at all times Rule 4: Don’t communicate about a manuscript outside of the journal system Rule 5: Remember the 90:10 rule: 10% of manuscripts will take 90% of your time Rule 6: Be prepared to adjudicate the majority of papers Rule 7: View yourself as a matchmaker between manuscripts and the journal Rule 8: Use the reviews—and the journal’s tools—judiciously Rule 9: Beware conflicts of interest Rule 10: The review process should improve a paper in a finite amount of time

Article

Commented on Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators
Interesting work! But how do the 2,3-disubstituted 4H-chromen-4-ones, which were identified in the study, enhance BMP activity and promote bone formation (osteogenic efficacy)?

Article

Commented on A GP130-Targeting Small Molecule, LMT-28, Reduces LPS-Induced Bone Resorption around Implants in Diabetic Models by Inhibiting IL-6/GP130/JAK2/STAT3 Signaling
This study showed that LMT-28, a molecule targeting GP130, was effective in reducing bone resorption around implants caused by LPS in diabetic rats. By downregulating RANKL expression through the JAK2/STAT3 pathway, LMT-28 reduced bone resorption and decreased osteoclast activity. These findings suggest that LMT-28 has potential as a therapeutic option for managing peri-implantitis in individuals with diabetes.

Article

Commented on Sequential application of small molecule therapy enhances chondrogenesis and angiogenesis in murine segmental defect bone repair
In this study, scientists aimed to improve bone fracture healing by using two small molecules in a novel therapeutic approach. They administered smoothened agonist 21k (SAG21k) to activate the sonic hedgehog pathway and stimulate cartilage development, along with injections of prolyl hydroxylase domain 2 (PHD2) inhibitor, IOX2, to enhance endochondral bone formation. The combined SAG-IOX2 therapy proved successful in promoting cartilage and bone formation in a murine femoral segmental defect nonunion model, indicating its potential to enhance fracture callus development in challenging bone injuries. Very interesting work!

Article

Commented on Genetically modified cell spheroids for tissue engineering and regenerative medicine
In this article, the authors provided a comprehensive review of the progress, applications, development timeline, limitations, and future prospects concerning genetically modified cell spheroids.

Article

Commented on Regenerative engineering of long bones using the small molecule forskolin
One of my recent research articles published in PNAS last month. Briefly, the utilization of short-term small molecule forskolin treatment as a regenerative approach for long bone regeneration in rabbits is a focal point of interest in this context.

Article

Commented on Osteochondral Interface: Regenerative Engineering and Challenges
The tidemark, a selectively permeable membrane forming part of the OC interface, has received limited attention in current research. However, its regeneration is crucial for accurately replicating the native structure and function of osteochondral tissues.

Webinar

Commented on A New Theory: Lipedema is Caused by Subclinical Compartment Syndrome
The webinar linking lipedema to subclinical compartment syndrome presents a novel and intriguing perspective on the condition. It could significantly impact our understanding of lipedema's underlying causes and potential treatment approaches.

Webinar

Commented on Robotic Aortic Valve Replacement (RAVR) - A New Alternative for Aortic Valve Disease
The expert panelists shed light on this alternative approach, providing a global update on its advancements and implications in the field of cardiac surgery.