Research on the SARS-CoV-2 spike glycoprotein, a key target for COVID-19 vaccines, reveals its ability to bind and oxidize heme, potentially helping the virus evade the immune system by reducing free heme levels during infection.
Interesting review in JBC. Covalent modifications like phosphorylation, sulfation, adenylation, halogenation, and nitration significantly expand the functional capabilities of proteins, particularly through modifications of tyrosine residues. An updated database of 908 human nitrated proteins reveals that tyrosine nitration, often overlapping with phosphorylation sites, plays a significant role in cell signaling and cancer biology, presenting new opportunities for research.
This is a good article published in JBC. Take a look of what we can use AI. The Journal of Biological Chemistry is releasing a position statement to define appropriate and inappropriate uses of AI-based chat technologies in the preparation and review of manuscripts being considered for publication.
A new study published in JBC shows that some bacteria have beneficially evolved the ability to mistranslate specific parts of the genetic code, a trait that allows improved antibiotic resistance.
What are the specific strategies and plans that leaders in care improvement for adults with Cerebral Palsy will implement in the next phase of their work to address pain management, a significant factor affecting quality of life in these adults?
Interesting paper published in Cell. The high-throughput studies have shown that enhancer dysfunction and 3D genomic interactions play a key role in cancer development, with genetic variations in enhancer regions affecting gene expression and cancer susceptibility, leading to advances in cancer treatment and management.
A series of carbamate-bearing derivatives based on DDO-6101, derived from the natural product gambogic acid, were synthesized to enhance its physicochemical properties and in vivo cytotoxic potency. One such derivative, 8n (DDO-6337), with a bipiperidine carbamate moiety, demonstrated improved drug properties, potential in vivo antitumor activity, and works by inhibiting the ATPase activity of Hsp90, leading to anti-angiogenesis and antitumor effects.
Observing neutrinoless double β decay is crucial for proving that neutrinos are their own antiparticles, but its detection is challenging due to its extremely long lifetime and the need to distinguish it from similar radioactive backgrounds. The proposed method involves a 'barium-tagging' experiment, using a novel sensor with a fluorescent bicolour indicator to detect single Ba2+ ions, a product of the decay of 136Xe, in high-pressure xenon gas detectors, enhancing the ability to identify this rare decay event.
Seems this website has all relevant postdoctoral fellowships, check this:
https://scholarship-positions.com/category/postdoctoral-fellowships-positions-jobs/
Clinicians should not prescribe tetracyclines and fluoroquinolones for young children under normal circumstances. Macrolides are generally considered the treatment of choice.
Last week, WHO has made an official request to China for detailed information on an increase in respiratory illnesses and reported clusters of pneumonia in children.
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