Wai Lo

United States UConn

Article

Commented on Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators
Interesting work! But how do the 2,3-disubstituted 4H-chromen-4-ones, which were identified in the study, enhance BMP activity and promote bone formation (osteogenic efficacy)?

Article

Commented on A GP130-Targeting Small Molecule, LMT-28, Reduces LPS-Induced Bone Resorption around Implants in Diabetic Models by Inhibiting IL-6/GP130/JAK2/STAT3 Signaling
This study showed that LMT-28, a molecule targeting GP130, was effective in reducing bone resorption around implants caused by LPS in diabetic rats. By downregulating RANKL expression through the JAK2/STAT3 pathway, LMT-28 reduced bone resorption and decreased osteoclast activity. These findings suggest that LMT-28 has potential as a therapeutic option for managing peri-implantitis in individuals with diabetes.

Article

Commented on Sequential application of small molecule therapy enhances chondrogenesis and angiogenesis in murine segmental defect bone repair
In this study, scientists aimed to improve bone fracture healing by using two small molecules in a novel therapeutic approach. They administered smoothened agonist 21k (SAG21k) to activate the sonic hedgehog pathway and stimulate cartilage development, along with injections of prolyl hydroxylase domain 2 (PHD2) inhibitor, IOX2, to enhance endochondral bone formation. The combined SAG-IOX2 therapy proved successful in promoting cartilage and bone formation in a murine femoral segmental defect nonunion model, indicating its potential to enhance fracture callus development in challenging bone injuries. Very interesting work!

Article

Commented on Genetically modified cell spheroids for tissue engineering and regenerative medicine
In this article, the authors provided a comprehensive review of the progress, applications, development timeline, limitations, and future prospects concerning genetically modified cell spheroids.

Article

Commented on Regenerative engineering of long bones using the small molecule forskolin
One of my recent research articles published in PNAS last month. Briefly, the utilization of short-term small molecule forskolin treatment as a regenerative approach for long bone regeneration in rabbits is a focal point of interest in this context.

Article

Commented on Osteochondral Interface: Regenerative Engineering and Challenges
The tidemark, a selectively permeable membrane forming part of the OC interface, has received limited attention in current research. However, its regeneration is crucial for accurately replicating the native structure and function of osteochondral tissues.

Webinar

Commented on A New Theory: Lipedema is Caused by Subclinical Compartment Syndrome
The webinar linking lipedema to subclinical compartment syndrome presents a novel and intriguing perspective on the condition. It could significantly impact our understanding of lipedema's underlying causes and potential treatment approaches.

Webinar

Commented on Robotic Aortic Valve Replacement (RAVR) - A New Alternative for Aortic Valve Disease
The expert panelists shed light on this alternative approach, providing a global update on its advancements and implications in the field of cardiac surgery.

Poster

Commented on Effect of the modifying ruthenium additive on the structure and activity of iron-containing catalysts
By the way, what are the key findings and advantages of the ruthenium-doped iron catalyst synthesized by subcritical deposition, as observed in the study?

Poster

Commented on Synthesis and properties of bicomponent complex systems based on organic acid and polyoxometalate compound
The present poster work addresses the gap by focusing on the synthesis of deposited Mo-containing aluminum oxide systems, aiming to unravel their properties using modern physicochemical methods.

Poster

Commented on Unsaturated polyketones — a new type of functionalized rubbers
Nice work. But what is the effect of the content of 1,2-units in the butadiene rubber on the ketonization reaction with nitrous oxide (N2O)?

Article

Commented on NASA’s InSight mission on Mars—first glimpses of the planet’s interior from seismology
I feel missions like this can provide excellent opportunities for science outreach and education. Sharing the progress and findings of the mission with the public can spark interest in space exploration.

Article

Commented on Insights from early COVID-19 responses about promoting sustainable action
Great paper in a Nature journal. But how can we leverage the dynamics of personal norms that were observed during the COVID-19 pandemic to promote stronger public responses and effective mitigation of global environmental crises?

Poster

Commented on The effect of polyethylene with grafted maleic anhydride on the properties of secondary polypropylene with the inclusion of aluminosilicate microspheres
What is the effect of incorporating polyethylene with grafted maleic anhydride on the properties of secondary polypropylene when aluminosilicate microspheres are included?

Poster

Commented on The effect of polyethylene with grafted maleic anhydride on the properties of secondary polypropylene with the inclusion of aluminosilicate microspheres
Seems interesting! The effect of polyethylene with grafted maleic anhydride on the properties of secondary polypropylene with the inclusion of aluminosilicate microspheres?