Wai Lo

United States UConn

Webinar

Commented on The Neuroscience of Change with Susan Levin
The webinar features Dr Susan Levin from Columbia University delving into the brain's reactions to unwelcome or unexpected change and offering practical strategies to handle the ensuing conflict. But what are the practical approaches to manage the conflict that arises from such changes?

Article

Commented on Advances in Copper-Based Biomaterials With Antibacterial and Osteogenic Properties for Bone Tissue Engineering
Very important topic. This review focuses on antibacterial biomaterials and strategies; it presents recently reported biomaterials, including antibacterial implants, antibacterial scaffolds, antibacterial hydrogels, and antibacterial bone cement types, and aims to provide an overview of these antibacterial materials for application in biomedicine. The antibacterial mechanisms of these materials are discussed as well.

Article

Commented on Biomimetic Materials and Fabrication Approaches for Bone Tissue Engineering
Bone tissue engineering strategies employ biomimetic scaffolds to address critically sized bone defects, with these scaffolds offering stable tissue formation and aiding stem cell differentiation. Recent advancements focus on optimizing osteoinductive scaffold materials and using innovative fabrication methods like 3D printing to replicate native bone microarchitecture for effective tissue regeneration.

Article

Commented on Silk Biomaterials for Bone Tissue Engineering
This is my research interest. Silk's biocompatibility, biodegradability, and mechanical properties have spurred its use in bone tissue engineering, with recent advances in silk-based biomaterials, including the incorporation of growth factors, drugs, and stem cells, showcasing its potential in enhancing bone regeneration.

Article

Commented on Nanodevices for deep cartilage penetration
Recent advancements in nanotechnology, including the use of exosomes and cationic nanocarriers, offer promising solutions for penetrating deep into the cartilage, although more optimization is needed before clinical applications can be realized. It is known that osteoarthritis treatments often struggle with delivery due to the dense, negatively charged cartilage barrier.

Article

Commented on Goldfish neurokinin B: Cloning, tissue distribution, and potential role in regulating reproduction
I found this very interesting as Neurokinin B (NKB), part of the tackykinin family, plays a pivotal role in mammalian reproduction, but its functions in teleost fish remain uncertain. This study, using goldfish, discovered two NKB-related transcripts predominantly expressed in the brain, and it was found that certain NKB forms influenced reproductive hormone levels, suggesting their involvement in estrogen's regulatory feedback on reproduction in goldfish.

Article

Commented on Avian influenza overview March – April 2023
Recent occurrences of avian influenza, commonly known as "bird flu", have had a significant impact on various animal groups such as poultry, wild birds, and certain mammals. These outbreaks have also negatively affected the livelihoods of farmers and the food industry. While the primary victims are animals, there remains a persistent threat to human health.

Article

Commented on Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling
Great article. How do changes in the epithelial population, defined by a mixed luminal-basal phenotype, contribute to lineage plasticity in prostate cancer, and what role does the upregulation of JAK/STAT and FGFR signaling pathways play in antiandrogen resistance in both murine models and patients with metastatic disease?

Article

Commented on Inhibitory activity of narirutin on RBL-2H3 cells degranulation
What is the question? Context: It is an efficient strategy to apply inhibition of mast cell degranulation for evaluating anti-allergic effects of compounds. Previous works confirmed that narirutin had anti-allergic activity in OVA induced allergic asthma murine model. However, the mechanism is not clear. Objective: Here, inhibitory mechanism of narirutin on RBL-2H3 cells degranulation was investigated. Materials and methods: Cell viability was analyzed by CCK-8 kits, cell degranulation was analyzed by ELISA methods, morphology and ultrastructure of cells was observed by atomic force microscopy, intracellular Ca 2+ concentration was measured by fluorescence microscopre, mRNA expression were measured by PCR, and signaling pathways were measured by WB. Results: The results showed that narirutin have no direct effects on mRNA expression of FcεRI subunit. However, it inhibited Ca2+ influx by suppressing the phosphorylation of Syk, LAT and PLCγ1 signaling pathway transduction. Subsequently, the inhibition of Ca2+ influx directly leads to NF-κB signaling pathway transduction decreased. Narirutin can also suppress the phosphorylation of MAPK signaling pathways by decreasing the expression of P-p38, P-ERK and P-JNK, inhibit the synergistic effect for Ca2+ influx, and then reduce the release of IL-4, TNF-α, histamine and β-HEX. Conclusion: Our study suggested that the inhibitory mechanism of narirutin on RBL-2H3 cells degranulation could be related to regulate MAPK, NF-κB and Tyrosine kinase signaling pathway.

Webinar

Commented on Adapting Your Research Methods in Response to COVID 19
Adapting research methods in response to COVID-19 is essential for both the safety of participants and researchers, as well as for the integrity and feasibility of the research itself.

Article

Commented on The COVID-19 pandemic in 2023: far from over
@Garan, seems never end. It will be part of our life, just likes flu. Nowadays seems to me that no one really care about the Covid test and the vaccination, at least this happens in my region.

Article

Commented on The COVID-19 pandemic in 2023: far from over
There’s a new coronavirus variant topping the leaderboard in the United States: EG.5. New variant EG.5 is on the rise as Covid-19 cases and hospitalizations go up.

Article

Commented on Mesenchymal Stem Cell-Based Therapy for Retinal Degenerative Diseases: Experimental Models and Clinical Trials
This review article summarizes on the potential use of mesenchymal stem cells (MSCs) in treating retinal degenerative diseases, which are significant causes of impaired vision and blindness globally.

Article

Commented on SNF5 promotes cell proliferation and immune evasion in non-small cell lung cancer
How does the protein SNF5 help lung cancer cells hide from the immune system and grow more aggressively?

Article

Commented on Imparting Designer Biorecognition Functionality to Metal-Organic Frameworks by a DNA-Mediated Surface Engineering Strategy
This research work provides a versatile, efficient, and cost-effective method to modify the surface of MOFs for targeted applications, especially in fields like nanomedicine. The ability to specifically target certain cells (e.g., cancer cells) without apparent toxicity makes it a promising avenue for future therapeutic applications.