Neural tissue engineering, focusing on novel treatments for nervous system diseases, increasingly utilizes three-dimensional (3D) cell culture systems and microfluidic platforms for better growth and differentiation of neural cells. This review discusses the integration of stem cells and microfluidics in neural tissue engineering, highlighting advancements in cell culture techniques and the potential for developing complex systems like a "brain-on-a-chip".
MicroRNAs (miRNAs) are noncoding RNAs that regulate mRNA translation and can influence various gene networks, playing a key role in normal and pathological tissue development and repair, with growing efforts in developing miRNA-based therapies for regenerative medicine and tissue engineering, as discussed in this review.
Recent advancements in 3D cell culture and microfluidics have led to more accurate human organ models, allowing for precise control of the cellular environment and improved screening of therapeutics. However, these models often overlook the immune system, which is crucial for effective preclinical testing of treatments for immune-related diseases. This review discusses designing immune-competent models and their applications in therapeutic screening, including cancer treatment, engineered T cell evaluation, autoimmune modeling, and vaccine efficacy testing, highlighting the need for better integration of immune responses in future models.
The review mentions the use of decellularization methodologies and tissue/cell-derived ECM as scaffolds or growth supplements in cell propagation and differentiation for 3D tissue culture in vitro. Additionally, it reviews current preclinical applications of ECM components in modulating the wound-healing process.
Open Data and Research Hubs provide crucial platforms for accessing, sharing, and modifying a wide range of data, fostering innovation, transparency, and collaboration in various research fields. These hubs democratize information, support diverse research projects, and emphasize responsible data use and sharing.
In this article, when they tested in an experimental setting with artificially induced coronary artery occlusion, quantitative icECG ST-segment shift and CNN using pathophysiologic prediction criteria detect myocardial ischemia with similarly high accuracy.
The finding of normal or nonobstructive epicardial coronary arteries at coronary angiography does not exclude the presence of myocardial ischemia in some patients.
Historical and recent clinical trials, including the ISCHEMIA trial, show mixed results on the effectiveness of revascularization in chronic coronary artery disease, highlighting the need for further research on the role of stress-induced myocardial ischemia and advanced imaging techniques in treatment decisions.
Heart failure, primarily driven by coronary artery disease and myocardial ischemia due to altered coronary circulation, is a complex condition requiring deeper understanding of its pathophysiology to improve patient outcomes.
Bamboo represents a promising, sustainable construction material with unique advantages, especially in the context of green building practices. However, its successful incorporation in construction projects requires careful consideration of its limitations and proper treatment to ensure long-term performance and safety.
This study highlights the complex interplay between land use, environmental health, and resource management, emphasizing the need for sustainable development practices to safeguard critical resources like groundwater.
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