Wai Lo

United States UConn

Article

Commented on Structure of dynein–dynactin on microtubules shows tandem adaptor binding
This study explores the activation of cytoplasmic dynein by its cofactors, dynactin, and coiled-coil cargo adaptors. The researchers used a cryo-electron microscopy processing pipeline to determine the high-resolution structure of dynein-dynactin and the adaptor BICDR1 bound to microtubules, revealing the asymmetric interactions between dynein motor domains and their implications for motor recruitment by cargos in terms of stability and stoichiometry.

Article

Commented on Dynein at the kinetochore
Published in JCS, the review article highlights the role of kinetochore dynein in efficient and accurate spindle assembly and delves into the molecular mechanisms and commonalities with dynein regulation at other subcellular locations.

Article

Commented on Serotonin drives the activation of pulmonary artery adventitial fibroblasts and TGF-β1/Smad3-mediated fibrotic responses through 5-HT2A receptors
This paper highlights the significant role of serotonin (5-HT) in the development of pulmonary arterial remodeling, a crucial process in pulmonary arterial hypertension (PAH). By directly stimulating pulmonary artery adventitial fibroblasts (PAFs) through the 5-HT2A receptor, 5-HT induces excessive proliferation, migration, and fibrotic activation of PAFs, leading to phenotypic alterations and adventitia fibrosis.

Hub

Commented on Regulation of AI
AIs can be danger to human beings. Some of the major dangers of AI include misinformation, privacy concerns, the loss of jobs etc........

Funding

Commented on Combating hate speech online and offline
Yes, they are around. We need to implement effective regulatory measures and promoting digital literacy so we can prevent the spread of hate speech and foster a more tolerant and respectful online environment.

Webinar

Commented on ChatGPT: What is it and how will it impact me?
The impact is massive when AIs are learning how to train each other. It can't be revered.

Poster

Commented on Synthesis of magnetic polymer microspheres for bio-medical applications
The diffusion technique proposed for synthesizing magnetic polymer microspheres with carboxyl groups offers a controlled and precise method to incorporate functional groups on the microsphere surface. This allows for potential applications in targeted drug delivery, biomedical imaging, and other biotechnological and nanomedical fields.

Article

Commented on Selective motor activation in organelle transport along axons
Molecular motors, such as cytoplasmic dynein and kinesins, play a central role in this process, and their activity is tightly controlled by adaptors and effectors.

Article

Commented on Estimation of microtubule-generated forces using a DNA origami nanospring
In this article published in JSC, researchers have developed an experimental method using fluorescent spring-shaped DNA origami molecules to estimate microtubule-generated forces and monitor the recruitment of proteins at the force generation site simultaneously, providing a valuable tool for studying these processes without the need for complex instrumentation, such as optical trapping. The validation of DNA nanosprings against optical trapping results further confirms their effectiveness in studying the coupling of protein activity with microtubule growth and shortening.

Article

Commented on Monkey pox: A public health emergency
It is a rare viral disease. It can be transmitted to humans from animals or from person to person through respiratory droplets, bodily fluids, or contact with infected materials.

Hub

Commented on Standardizing Journal Articles
Yes, the world would likely be a better place if there were more standardization for how researchers report their results and protocols in peer-reviewed journals.

Hub

Commented on Science & Policy Engagement Hub
Engaging in policy-related work offers a unique opportunity to contribute to positive change, foster inclusive decision-making processes, and make a lasting impact on society.

Hub

Commented on Intellectual Property Rights
Intellectual property plays a crucial role in fostering innovation, protecting the rights of creators and inventors, and promoting economic growth by encouraging the development and dissemination of new ideas and products.

Funding

Commented on DoD Tick-Borne Disease Research Program Idea Development Award
The most common tick-borne disease in the United States is Lyme disease.

Article

Commented on Ten simple rules for serving as an editor
My favorite ten simple rules paper published in PLoS, here is the new paper on how to serve as an editor, I have copied and pasted the 10 rules here: Rule 1: Only accept an invitation if you can do it—be dedicated to it, and ensure you can realistically prioritize it Rule 2: Draw upon your experiences to guide your decision-making as an editor—Look backward (on your own experiences), and look forward (with appreciation and respect) Rule 3: Be fair and objective in judging the work, and treat all parties respectfully at all times Rule 4: Don’t communicate about a manuscript outside of the journal system Rule 5: Remember the 90:10 rule: 10% of manuscripts will take 90% of your time Rule 6: Be prepared to adjudicate the majority of papers Rule 7: View yourself as a matchmaker between manuscripts and the journal Rule 8: Use the reviews—and the journal’s tools—judiciously Rule 9: Beware conflicts of interest Rule 10: The review process should improve a paper in a finite amount of time