This study explores the activation of cytoplasmic dynein by its cofactors, dynactin, and coiled-coil cargo adaptors. The researchers used a cryo-electron microscopy processing pipeline to determine the high-resolution structure of dynein-dynactin and the adaptor BICDR1 bound to microtubules, revealing the asymmetric interactions between dynein motor domains and their implications for motor recruitment by cargos in terms of stability and stoichiometry.
Published in JCS, the review article highlights the role of kinetochore dynein in efficient and accurate spindle assembly and delves into the molecular mechanisms and commonalities with dynein regulation at other subcellular locations.
This paper highlights the significant role of serotonin (5-HT) in the development of pulmonary arterial remodeling, a crucial process in pulmonary arterial hypertension (PAH). By directly stimulating pulmonary artery adventitial fibroblasts (PAFs) through the 5-HT2A receptor, 5-HT induces excessive proliferation, migration, and fibrotic activation of PAFs, leading to phenotypic alterations and adventitia fibrosis.
Yes, they are around. We need to implement effective regulatory measures and promoting digital literacy so we can prevent the spread of hate speech and foster a more tolerant and respectful online environment.
The diffusion technique proposed for synthesizing magnetic polymer microspheres with carboxyl groups offers a controlled and precise method to incorporate functional groups on the microsphere surface. This allows for potential applications in targeted drug delivery, biomedical imaging, and other biotechnological and nanomedical fields.
Molecular motors, such as cytoplasmic dynein and kinesins, play a central role in this process, and their activity is tightly controlled by adaptors and effectors.
In this article published in JSC, researchers have developed an experimental method using fluorescent spring-shaped DNA origami molecules to estimate microtubule-generated forces and monitor the recruitment of proteins at the force generation site simultaneously, providing a valuable tool for studying these processes without the need for complex instrumentation, such as optical trapping. The validation of DNA nanosprings against optical trapping results further confirms their effectiveness in studying the coupling of protein activity with microtubule growth and shortening.
It is a rare viral disease. It can be transmitted to humans from animals or from person to person through respiratory droplets, bodily fluids, or contact with infected materials.
Yes, the world would likely be a better place if there were more standardization for how researchers report their results and protocols in peer-reviewed journals.
Engaging in policy-related work offers a unique opportunity to contribute to positive change, foster inclusive decision-making processes, and make a lasting impact on society.
Intellectual property plays a crucial role in fostering innovation, protecting the rights of creators and inventors, and promoting economic growth by encouraging the development and dissemination of new ideas and products.
My favorite ten simple rules paper published in PLoS, here is the new paper on how to serve as an editor, I have copied and pasted the 10 rules here:
Rule 1: Only accept an invitation if you can do it—be dedicated to it, and ensure you can realistically prioritize it
Rule 2: Draw upon your experiences to guide your decision-making as an editor—Look backward (on your own experiences), and look forward (with appreciation and respect)
Rule 3: Be fair and objective in judging the work, and treat all parties respectfully at all times
Rule 4: Don’t communicate about a manuscript outside of the journal system
Rule 5: Remember the 90:10 rule: 10% of manuscripts will take 90% of your time
Rule 6: Be prepared to adjudicate the majority of papers
Rule 7: View yourself as a matchmaker between manuscripts and the journal
Rule 8: Use the reviews—and the journal’s tools—judiciously
Rule 9: Beware conflicts of interest
Rule 10: The review process should improve a paper in a finite amount of time
Article