Wai Lo

United States UConn

Article

Commented on Structural basis for the bypass of the major oxaliplatin–DNA adducts by human DNA polymerase η
The study reveals the first structure of DNA polymerase η (Polη) interacting with oxaliplatin-modified DNA, explaining how Polη bypasses oxaliplatin-induced (DACH)Pt–GpG DNA adducts, which contribute to tumor resistance to platinum-based chemotherapy. This structural insight into enzyme adaptation offers a pathway to potentially overcoming chemoresistance.

Article

Commented on Calcium-Calmodulin Gating of a pH-insensitive isoform of Connexin43 Gap Junctions
The study investigates how calcium ions affect the junctional conductance of connexin43 (Cx43) gap junctions, particularly when the pH-sensitivity of these junctions is disabled using mutants. Using techniques such as patch clamp experiments on cells expressing either standard Cx43 or a pH-insensitive mutant, researchers found that calcium reduction via chelation or calmodulin inhibitors prevented the loss of conductance caused by calcium. These results suggest that the distal carboxyl-terminal domain of Cx43 influences voltage-dependent inactivation, but calcium/calmodulin-dependent gating still operates without this domain, indicating potential targets for modulating Cx43 function.

Article

Commented on Metabolic profiling of visceral adipose tissue from obese subjects with or without metabolic syndrome
Obesity has escalated to epidemic levels and is a major cause of metabolic syndrome, characterized by factors like dyslipidemia, hypertension, and hyperglycemia, which also increase cancer risk. A study examining metabolomic profiles in visceral adipose tissue from various obese groups using advanced techniques revealed increased oxidative stress markers and other changes associated with metabolic complications, potentially guiding new treatments for these conditions.

Webinar

Commented on Updates in the Management of Portal Hypertension
This is an important webinar for people who suffer from high blood pressure.

Article

Commented on Antibody specificity and promiscuity
This review explores the balance between antibody specificity and promiscuity, the structural adaptations enabling this behavior, and the implications of rapid antigen evolution and molecular mimicry.

Article

Commented on The chemical diversity of RNA modifications
Interesting review. Over 150 RNA modifications exist, impacting various RNAs and playing crucial roles in biological processes like stem cell differentiation. These modifications are dynamically regulated by specific enzymes and their dysregulation can lead to diseases, including cancer. This review delves into the chemical and biological roles of these modifications in RNA species.

Article

Commented on Mechanisms of lipid droplet biogenesis
Lipid droplets (LDs) are organelles found in the cytoplasm of most organisms, including animals, plants, and microorganisms, where they store nonbilayer-forming lipids such as triacylglycerols and steryl esters. These LDs are typically derived from the endoplasmic reticulum in eukaryotes through a budding process that varies across species due to the use of distinct, sometimes unique, LD-packaging proteins, highlighting the complex and diverse mechanisms of LD biogenesis.

Article

Commented on The growth of amyloid fibrils: rates and mechanisms
Amyloid fibrils are β-sheet-rich protein polymers involved in various human disorders but also play beneficial roles in biological systems due to their unique structural properties. This article reviews in vitro studies on amyloid fibril growth, comparing their elongation kinetics to other protein polymers and summarizing experimental data on factors affecting their growth rates.

Article

Commented on STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain
Upon detecting viral or bacterial DNA, mammalian cells activate the cGAS-STING pathway, triggering interferon β expression and initiating innate immune defenses. This pathway also promotes an unconventional LC3B lipidation on single-membrane perinuclear vesicles, a process mediated by ATG16L1 that bypasses traditional autophagy mechanisms and is inhibited by both bafilomycin A1 and the bacterial effector SopF, highlighting a unique host defense mechanism against infections.

Article

Commented on SuperPlots: Communicating reproducibility and variability in cell biology
P values and error bars help readers infer whether a reported difference would likely recur, with the sample size n used for statistical tests representing biological replicates, independent measurements of the population from separate experiments.

Article

Commented on Wapl releases Scc1-cohesin and regulates chromosome structure and segregation in mouse oocytes
Cohesin, crucial for genome folding and inheritance, operates differently in mammalian oocytes where Rec8-cohesin mediates cohesion, with Scc1-cohesin's role unclear despite its presence. Research reveals Wapl's essential role in meiosis I chromosome segregation by primarily releasing Scc1-cohesin and facilitating euploid egg production, while also highlighting Scc1's necessity for chromosome organization, with Wapl depletion leading to abnormal chromosomal structures.

Article

Commented on An intrinsic compartmentalization code for peripheral membrane proteins in photoreceptor neurons
Peripheral membrane proteins in neurons, key for information transfer and transduction, are compartmentalized through unknown mechanisms; this study used probes with lipidation motifs and differently charged linkers expressed in Xenopus rod photoreceptors to investigate. Live imaging revealed variations in probe distribution based on lipid and charge, challenging previous ciliary enrichment models by demonstrating weak membrane binding and diffusion without needing chaperone proteins, suggesting a leaky cilium barrier facilitates a recycling enrichment process.

Journal

Commented on Translational Behavioral Medicine
This journal is longer published by Springer Nature. It has been transferred to other publisher -Oxford Academic.

Journal

Commented on PHOTOSYNTHETICA
This journal is no lonfer published by Springer Nature. It is currently published by the Institute of Experimental Botany.

Journal

Commented on BIOLOGIA PLANTARUM
This journal is no longer published by Spirnger Narure. It is currently published by the Institute of Experimental Botany, Academy of Sciences of the Czech Republic.