Cellular Trafficking of Amyloid Precursor Protein in Amyloidogenesis Physiological and Pathological Significance
出版年份 2018 全文链接
标题
Cellular Trafficking of Amyloid Precursor Protein in Amyloidogenesis Physiological and Pathological Significance
作者
关键词
APP, BACE1, Cellular trafficking, Gamma-secretase, Amyloidogenesis
出版物
MOLECULAR NEUROBIOLOGY
Volume -, Issue -, Pages -
出版商
Springer Nature
发表日期
2018-05-24
DOI
10.1007/s12035-018-1106-9
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Sortilin inhibits amyloid pathology by regulating non-specific degradation of APP
- (2018) Chun-Sheng Ruan et al. EXPERIMENTAL NEUROLOGY
- GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates Aβ production
- (2018) Wei Hong Toh et al. MOLECULAR BIOLOGY OF THE CELL
- Alzheimer's Disease: Recent Advances and Future Perspectives
- (2018) Kiren Ubhi et al. JOURNAL OF ALZHEIMERS DISEASE
- Small Molecule p75NTR Ligands Reduce Pathological Phosphorylation and Misfolding of Tau, Inflammatory Changes, Cholinergic Degeneration, and Cognitive Deficits in AβPPL/S Transgenic Mice
- (2018) Thuy-Vi V. Nguyen et al. JOURNAL OF ALZHEIMERS DISEASE
- The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer’s Disease Neuropathology
- (2017) Nadia Canu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis
- (2017) Khalil Saadipour et al. JOURNAL OF NEUROCHEMISTRY
- Targeting amyloid precursor protein shuttling and processing - long before amyloid beta formation
- (2017) Sage Arbor Neural Regeneration Research
- Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b- and AP4-dependent pathway
- (2017) Wei Hong Toh et al. TRAFFIC
- Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum
- (2017) Xia Hu et al. Frontiers in Neuroanatomy
- Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1
- (2017) Na-Young Kim et al. Alzheimers Research & Therapy
- Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction
- (2017) Lukas P. Feilen et al. Frontiers in Molecular Neuroscience
- Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents
- (2017) Nadia Canu et al. Frontiers in Molecular Neuroscience
- Functional Roles of the Interaction of APP and Lipoprotein Receptors
- (2017) Theresa Pohlkamp et al. Frontiers in Molecular Neuroscience
- Amyloid-β Peptides Stimulate the Expression of the p75NTR Neurotrophin Receptor in SHSY5Y Human Neuroblastoma Cells and AD Transgenic Mice
- (2017) Balu Chakravarthy et al. JOURNAL OF ALZHEIMERS DISEASE
- NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease
- (2016) Viviana Triaca et al. AGING CELL
- 2016 Alzheimer's disease facts and figures
- (2016) Alzheimers & Dementia
- Genomic variants, genes, and pathways of Alzheimer's disease: An overview
- (2016) Adam C. Naj et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
- Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D‐serine homeostasis
- (2016) Chengyu Zou et al. EMBO JOURNAL
- Mice with Sort1 deficiency display normal cognition but elevated anxiety-like behavior
- (2016) Chun-Sheng Ruan et al. EXPERIMENTAL NEUROLOGY
- A small molecule p75NTRligand normalizes signalling and reduces Huntington’s disease phenotypes in R6/2 and BACHD mice
- (2016) Danielle A. Simmons et al. HUMAN MOLECULAR GENETICS
- Gamma Secretase Modulators: New Alzheimer’s Drugs on the Horizon?
- (2016) Matthew G. Bursavich et al. JOURNAL OF MEDICINAL CHEMISTRY
- In vivo knockdown of basal forebrain p75 neurotrophin receptor stimulates choline acetyltransferase activity in the mature hippocampus
- (2016) Graham L. Barrett et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Cleavage of p75 neurotrophin receptor is linked to Alzheimer’s disease
- (2016) M V Chao MOLECULAR PSYCHIATRY
- Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
- (2016) Poomy Pandey et al. Oncotarget
- Tyrosine Binding Protein Sites Regulate the Intracellular Trafficking and Processing of Amyloid Precursor Protein through a Novel Lysosome-Directed Pathway
- (2016) Joshua H. K. Tam et al. PLoS One
- New Insights to Clathrin and Adaptor Protein 2 for the Design and Development of Therapeutic Strategies
- (2015) Ebbe Poulsen et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A Pro-Nerve Growth Factor (proNGF) and NGF Binding Protein, α2-Macroglobulin, Differentially Regulates p75 and TrkA Receptors and Is Relevant to NeurodegenerationEx VivoandIn Vivo
- (2015) Pablo F. Barcelona et al. MOLECULAR AND CELLULAR BIOLOGY
- p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer’s disease
- (2015) X-Q Yao et al. MOLECULAR PSYCHIATRY
- The p75 neurotrophin receptor: at the crossroad of neural repair and death
- (2015) RickB Meeker et al. Neural Regeneration Research
- The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)
- (2015) Bjoern von Einem et al. PLoS One
- The Normal and Pathologic Roles of the Alzheimer's β-secretase, BACE1
- (2014) Patty Kandalepas et al. Current Alzheimer Research
- A Role for the p75 Neurotrophin Receptor in Axonal Degeneration and Apoptosis Induced by Oxidative Stress
- (2014) Bradley R. Kraemer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease
- (2014) Edgar Dawkins et al. JOURNAL OF NEUROCHEMISTRY
- Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport
- (2014) Kyoko Chiba et al. MOLECULAR BIOLOGY OF THE CELL
- Trafficking regulation of proteins in Alzheimer’s disease
- (2014) Shangtong Jiang et al. Molecular Neurodegeneration
- The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid
- (2014) Joshua HK Tam et al. Molecular Brain
- Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Aβ) peptide, guiding it to lysosomes for degradation in basal forebrain cholinergic neurons
- (2013) Saak V. Ovsepian et al. Brain Structure & Function
- ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice
- (2013) C Tiveron et al. CELL DEATH AND DIFFERENTIATION
- Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms
- (2013) Amy R. Wyatt et al. FEBS LETTERS
- The amyloid precursor protein: A biochemical enigma in brain development, function and disease
- (2013) Natalia N. Nalivaeva et al. FEBS LETTERS
- Amyloid beta1-42(Aβ42) up-regulates the expression of sortilin via the p75NTR/RhoA signaling pathway
- (2013) Khalil Saadipour et al. JOURNAL OF NEUROCHEMISTRY
- Up-regulation of sortilin mediated by amyloid-β and p75NTR: safety lies in the middle course
- (2013) Elizabeth J. Coulson et al. JOURNAL OF NEUROCHEMISTRY
- The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid- Peptide in the Brain
- (2013) A.-S. Carlo et al. JOURNAL OF NEUROSCIENCE
- Sortilin and SorLA Display Distinct Roles in Processing and Trafficking of Amyloid Precursor Protein
- (2013) C. Gustafsen et al. JOURNAL OF NEUROSCIENCE
- Pharmacologic Inhibition of ROCK2 Suppresses Amyloid- Production in an Alzheimer's Disease Mouse Model
- (2013) J. H. Herskowitz et al. JOURNAL OF NEUROSCIENCE
- A small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model
- (2013) Juliet K. Knowles et al. NEUROBIOLOGY OF AGING
- The Intracellular Domain of Sortilin Interacts with Amyloid Precursor Protein and Regulates Its Lysosomal and Lipid Raft Trafficking
- (2013) Miao Yang et al. PLoS One
- Soluble β-amyloid Precursor Protein Alpha Binds to p75 Neurotrophin Receptor to Promote Neurite Outgrowth
- (2013) Noriko Hasebe et al. PLoS One
- Two gigs of Munc18 in membrane fusion
- (2013) Y.-K. Shin PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins
- (2013) R. Ghai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
- (2013) Xiaojie Zhang et al. Alzheimers Research & Therapy
- Trafficking and Proteolytic Processing of APP
- (2013) C. Haass et al. Cold Spring Harbor Perspectives in Medicine
- Reprint of “Alzheimer’s disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein”
- (2012) George G. Glenner BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Functions of neurotrophins and growth factors in neurogenesis and brain repair
- (2012) Sophia L. B. Oliveira et al. CYTOMETRY PART A
- CutA Divalent Cation Tolerance Homolog (Escherichia coli) (CUTA) Regulates β-Cleavage of β-Amyloid Precursor Protein (APP) through Interacting with β-Site APP Cleaving Protein 1 (BACE1)
- (2012) Yingjun Zhao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis
- (2012) Sune Skeldal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hippocampal ProNGF Signaling Pathways and β-Amyloid Levels in Mild Cognitive Impairment and Alzheimer Disease
- (2012) Elliott J. Mufson et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Intracellular Amyloid Precursor Protein Sorting and Amyloid- Secretion Are Regulated by Src-Mediated Phosphorylation of Mint2
- (2012) J. Chaufty et al. JOURNAL OF NEUROSCIENCE
- Adaptor protein 2–mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing
- (2012) Yogikala Prabhu et al. MOLECULAR BIOLOGY OF THE CELL
- GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production
- (2012) Jeremy H. Herskowitz et al. MOLECULAR BIOLOGY OF THE CELL
- LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer’s disease
- (2012) Julie Brodeur et al. Molecular Neurodegeneration
- Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
- (2012) Yonghao Zhao et al. Molecular Neurodegeneration
- Membrane Trafficking Pathways in Alzheimer's Disease
- (2012) Lawrence Rajendran et al. TRAFFIC
- p75 neurotrophin receptor signaling in nervous system injury and degeneration: paradox and opportunity
- (2012) Carlos F. Ibáñez et al. TRENDS IN NEUROSCIENCES
- Roles of p75NTR in the pathogenesis of Alzheimer's disease: A novel therapeutic target
- (2011) Fan Zeng et al. BIOCHEMICAL PHARMACOLOGY
- APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP
- (2011) Sascha W Weyer et al. EMBO JOURNAL
- Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling
- (2011) Xuan Xu et al. EMBO REPORTS
- Intracellular trafficking of the β-secretase and processing of amyloid precursor protein
- (2011) Pei Zhi et al. IUBMB LIFE
- BACE1 Retrograde Trafficking Is Uniquely Regulated by the Cytoplasmic Domain of Sortilin
- (2011) Gina M. Finan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology
- (2011) Lei Wen et al. JOURNAL OF CELL BIOLOGY
- The physiology of the β-amyloid precursor protein intracellular domain AICD
- (2011) Raphaëlle Pardossi-Piquard et al. JOURNAL OF NEUROCHEMISTRY
- p75NTR Regulates A Deposition by Increasing A Production But Inhibiting A Aggregation with Its Extracellular Domain
- (2011) Y.-J. Wang et al. JOURNAL OF NEUROSCIENCE
- ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1
- (2011) R. Sannerud et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Does the term ‘trophic’ actually mean anti-amyloidogenic? The case of NGF
- (2010) P Calissano et al. CELL DEATH AND DIFFERENTIATION
- The Upside of APP at Synapses
- (2010) Hyang-Sook Hoe et al. CNS Neuroscience & Therapeutics
- Sorting of the Alzheimer's Disease Amyloid Precursor Protein Mediated by the AP-4 Complex
- (2010) Patricia V. Burgos et al. DEVELOPMENTAL CELL
- Nerve growth factor as a paradigm of neurotrophins related to Alzheimer's disease
- (2010) P. Calissano et al. Developmental Neurobiology
- Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing
- (2010) Hirokazu Okada et al. FASEB JOURNAL
- Neurotrophic factors in Alzheimer’s disease: role of axonal transport
- (2010) K. Schindowski et al. GENES BRAIN AND BEHAVIOR
- BACE: Therapeutic target and potential biomarker for Alzheimer's disease
- (2010) Geneviève Evin et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a β-Secretase-dependent Pathway
- (2010) Nikolai D. Belyaev et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dab1 binds to Fe65 and diminishes the effect of Fe65 or LRP1 on APP processing
- (2010) Oh Yeun Kwon et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Phosphorylation of APP-CTF-AICD domains and interaction with adaptor proteins: signal transduction and/or transcriptional role - relevance for Alzheimer pathology
- (2010) Gennaro Schettini et al. JOURNAL OF NEUROCHEMISTRY
- Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain
- (2010) Maho Kondo et al. Molecular Neurodegeneration
- Preservation of cortical sortilin protein levels in MCI and Alzheimer's disease
- (2010) Elliott J. Mufson et al. NEUROSCIENCE LETTERS
- Selective vulnerability in Alzheimer's disease: Amyloid precursor protein and p75NTRinteraction
- (2009) Joanna Fombonne et al. ANNALS OF NEUROLOGY
- The proNGF-p75NTR-Sortilin Signalling Complex as New Target for the Therapeutic Treatment of Parkinsons Disease
- (2009) L. Chen et al. CNS & Neurological Disorders-Drug Targets
- Enhanced spatial memory and hippocampal long-term potentiation in p75 neurotrophin receptor knockout mice
- (2009) Graham L. Barrett et al. HIPPOCAMPUS
- The -Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential
- (2009) R. Vassar et al. JOURNAL OF NEUROSCIENCE
- The p75 Neurotrophin Receptor Promotes Amyloid- (1-42)-Induced Neuritic Dystrophy In Vitro and In Vivo
- (2009) J. K. Knowles et al. JOURNAL OF NEUROSCIENCE
- The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains
- (2009) Robert Tamayev et al. Molecular Neurodegeneration
- A Novel Sorting Nexin Modulates Endocytic Trafficking and α-Secretase Cleavage of the Amyloid Precursor Protein
- (2008) Susanne Schöbel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Adaptor Protein Sorting Nexin 17 Regulates Amyloid Precursor Protein Trafficking and Processing in the Early Endosomes
- (2008) Jiyeon Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Amyloid Precursor Protein Trafficking, Processing, and Function
- (2008) Gopal Thinakaran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing
- (2008) Takashi Sakurai et al. JOURNAL OF CELL BIOLOGY
- -Amyloid1-42 Induces Neuronal Death through the p75 Neurotrophin Receptor
- (2008) A. Sotthibundhu et al. JOURNAL OF NEUROSCIENCE
- The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics—Relevance for Alzheimer's disease
- (2008) Thorsten Müller et al. PROGRESS IN NEUROBIOLOGY
- Mint3/X11γ Is an ADP-Ribosylation Factor-dependent Adaptor that Regulates the Traffic of the Alzheimer's Precursor Protein from the Trans-Golgi Network
- (2007) Punya Shrivastava-Ranjan et al. MOLECULAR BIOLOGY OF THE CELL
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