期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 33, 期 -, 页码 S185-S194出版社
IOS PRESS
DOI: 10.3233/JAD-2012-129028
关键词
Autophagy; chaperone; dementia; immunotherapy; neurotrophic factors; transgenic
资金
- NIH [AG18840, AG022074, NS057096]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P30NS057096, P30NS076411] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P50AG005131, P01AG031097, P01AG010435, P01AG022074, R37AG018440] Funding Source: NIH RePORTER
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by progressive memory deficits and other cognitive disturbances. Neuropathologically, AD is characterized by the progressive loss of basal forebrain cholinergic neurons that innervate the hippocampus and cortex and the abnormal extracellular accumulation of amyloid-beta and intracellular tau protein. Current research on AD is focused on the mechanisms underlying the abnormal oligomerization, fibrillation, and accumulation of the amyloid-beta and tau proteins, mechanisms that may alter the dynamics of this accumulation and on experimental therapeutics approaches aimed at the clearance of the abnormally folded proteins and other potentially neuroprotective interventions. This review will summarize the main areas of investigation in AD and present ways forward for future work.
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