期刊
ONCOTARGET
卷 7, 期 15, 页码 19430-19444出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.7103
关键词
amyloid precursor protein; amyloid precursor-like protein 2; cancer; growth; migration
资金
- Nebraska Research Initiative
- Fred & Pamela Buffett Cancer Center's NIH Cancer Center Support Grant [P30CA036727]
- Nebraska Center for Cellular Signaling (NIH Grant) [P30GM106397]
- State of Nebraska through the Pediatric Cancer Research Group [NIH R03CA169953, NIH R03CA176557, NIH SPORE P50CA127297]
- University of Nebraska Medical Center Graduate Studies Office Emley and Regents Tuition Fellowships
- NIH Training Grant [T32CA009476]
- Wellcome Trust/DBT India Alliance Intermediate Fellowship Award
- Wellcome Trust/DBT Alliance
- CSIR-IMTECH
Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane glycoproteins that are highly conserved across species. The transcriptional regulation of APP and APLP2 is similar but not identical, and the cleavage of both proteins is regulated by phosphorylation. APP has been implicated in Alzheimer's disease causation, and in addition to its importance in neurology, APP is deregulated in cancer cells. APLP2 is likewise overexpressed in cancer cells, and APLP2 and APP are linked to increased tumor cell proliferation, migration, and invasion. In this present review, we discuss the unfolding account of these APP family members' roles in cancer progression and metastasis.
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