Cellular Trafficking of Amyloid Precursor Protein in Amyloidogenesis Physiological and Pathological Significance

Sortilin inhibits amyloid pathology by regulating non-specific degradation of APP

(2018) Chun-Sheng Ruan et al.   EXPERIMENTAL NEUROLOGY

GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates Aβ production

(2018) Wei Hong Toh et al.   MOLECULAR BIOLOGY OF THE CELL

Alzheimer's Disease: Recent Advances and Future Perspectives

(2018) Kiren Ubhi et al.   JOURNAL OF ALZHEIMERS DISEASE

Small Molecule p75NTR Ligands Reduce Pathological Phosphorylation and Misfolding of Tau, Inflammatory Changes, Cholinergic Degeneration, and Cognitive Deficits in AβPPL/S Transgenic Mice

(2018) Thuy-Vi V. Nguyen et al.   JOURNAL OF ALZHEIMERS DISEASE

The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer’s Disease Neuropathology

(2017) Nadia Canu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis

(2017) Khalil Saadipour et al.   JOURNAL OF NEUROCHEMISTRY

Targeting amyloid precursor protein shuttling and processing - long before amyloid beta formation

(2017) Sage Arbor   Neural Regeneration Research

Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b- and AP4-dependent pathway

(2017) Wei Hong Toh et al.   TRAFFIC

Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum

(2017) Xia Hu et al.   Frontiers in Neuroanatomy

Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1

(2017) Na-Young Kim et al.   Alzheimers Research & Therapy

Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction

(2017) Lukas P. Feilen et al.   Frontiers in Molecular Neuroscience

Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents

(2017) Nadia Canu et al.   Frontiers in Molecular Neuroscience

Functional Roles of the Interaction of APP and Lipoprotein Receptors

(2017) Theresa Pohlkamp et al.   Frontiers in Molecular Neuroscience

Amyloid-β Peptides Stimulate the Expression of the p75NTR Neurotrophin Receptor in SHSY5Y Human Neuroblastoma Cells and AD Transgenic Mice

(2017) Balu Chakravarthy et al.   JOURNAL OF ALZHEIMERS DISEASE

NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease

(2016) Viviana Triaca et al.   AGING CELL

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

Genomic variants, genes, and pathways of Alzheimer's disease: An overview

(2016) Adam C. Naj et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D‐serine homeostasis

(2016) Chengyu Zou et al.   EMBO JOURNAL

Mice with Sort1 deficiency display normal cognition but elevated anxiety-like behavior

(2016) Chun-Sheng Ruan et al.   EXPERIMENTAL NEUROLOGY

A small molecule p75NTRligand normalizes signalling and reduces Huntington’s disease phenotypes in R6/2 and BACHD mice

(2016) Danielle A. Simmons et al.   HUMAN MOLECULAR GENETICS

Gamma Secretase Modulators: New Alzheimer’s Drugs on the Horizon?

(2016) Matthew G. Bursavich et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vivo knockdown of basal forebrain p75 neurotrophin receptor stimulates choline acetyltransferase activity in the mature hippocampus

(2016) Graham L. Barrett et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cleavage of p75 neurotrophin receptor is linked to Alzheimer’s disease

(2016) M V Chao   MOLECULAR PSYCHIATRY

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

(2016) Poomy Pandey et al.   Oncotarget

Tyrosine Binding Protein Sites Regulate the Intracellular Trafficking and Processing of Amyloid Precursor Protein through a Novel Lysosome-Directed Pathway

(2016) Joshua H. K. Tam et al.   PLoS One

New Insights to Clathrin and Adaptor Protein 2 for the Design and Development of Therapeutic Strategies

(2015) Ebbe Poulsen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Pro-Nerve Growth Factor (proNGF) and NGF Binding Protein, α2-Macroglobulin, Differentially Regulates p75 and TrkA Receptors and Is Relevant to NeurodegenerationEx VivoandIn Vivo

(2015) Pablo F. Barcelona et al.   MOLECULAR AND CELLULAR BIOLOGY

p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer’s disease

(2015) X-Q Yao et al.   MOLECULAR PSYCHIATRY

The p75 neurotrophin receptor: at the crossroad of neural repair and death

(2015) RickB Meeker et al.   Neural Regeneration Research

The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)

(2015) Bjoern von Einem et al.   PLoS One

The Normal and Pathologic Roles of the Alzheimer's β-secretase, BACE1

(2014) Patty Kandalepas et al.   Current Alzheimer Research

A Role for the p75 Neurotrophin Receptor in Axonal Degeneration and Apoptosis Induced by Oxidative Stress

(2014) Bradley R. Kraemer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease

(2014) Edgar Dawkins et al.   JOURNAL OF NEUROCHEMISTRY

Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport

(2014) Kyoko Chiba et al.   MOLECULAR BIOLOGY OF THE CELL

Trafficking regulation of proteins in Alzheimer’s disease

(2014) Shangtong Jiang et al.   Molecular Neurodegeneration

The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid

(2014) Joshua HK Tam et al.   Molecular Brain

Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Aβ) peptide, guiding it to lysosomes for degradation in basal forebrain cholinergic neurons

(2013) Saak V. Ovsepian et al.   Brain Structure & Function

ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice

(2013) C Tiveron et al.   CELL DEATH AND DIFFERENTIATION

Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms

(2013) Amy R. Wyatt et al.   FEBS LETTERS

The amyloid precursor protein: A biochemical enigma in brain development, function and disease

(2013) Natalia N. Nalivaeva et al.   FEBS LETTERS

Amyloid beta1-42(Aβ42) up-regulates the expression of sortilin via the p75NTR/RhoA signaling pathway

(2013) Khalil Saadipour et al.   JOURNAL OF NEUROCHEMISTRY

Up-regulation of sortilin mediated by amyloid-β and p75NTR: safety lies in the middle course

(2013) Elizabeth J. Coulson et al.   JOURNAL OF NEUROCHEMISTRY

The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid-  Peptide in the Brain

(2013) A.-S. Carlo et al.   JOURNAL OF NEUROSCIENCE

Sortilin and SorLA Display Distinct Roles in Processing and Trafficking of Amyloid Precursor Protein

(2013) C. Gustafsen et al.   JOURNAL OF NEUROSCIENCE

Pharmacologic Inhibition of ROCK2 Suppresses Amyloid-  Production in an Alzheimer's Disease Mouse Model

(2013) J. H. Herskowitz et al.   JOURNAL OF NEUROSCIENCE

A small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model

(2013) Juliet K. Knowles et al.   NEUROBIOLOGY OF AGING

The Intracellular Domain of Sortilin Interacts with Amyloid Precursor Protein and Regulates Its Lysosomal and Lipid Raft Trafficking

(2013) Miao Yang et al.   PLoS One

Soluble β-amyloid Precursor Protein Alpha Binds to p75 Neurotrophin Receptor to Promote Neurite Outgrowth

(2013) Noriko Hasebe et al.   PLoS One

Two gigs of Munc18 in membrane fusion

(2013) Y.-K. Shin   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

(2013) R. Ghai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation

(2013) Xiaojie Zhang et al.   Alzheimers Research & Therapy

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Reprint of “Alzheimer’s disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein”

(2012) George G. Glenner   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functions of neurotrophins and growth factors in neurogenesis and brain repair

(2012) Sophia L. B. Oliveira et al.   CYTOMETRY PART A

CutA Divalent Cation Tolerance Homolog (Escherichia coli) (CUTA) Regulates β-Cleavage of β-Amyloid Precursor Protein (APP) through Interacting with β-Site APP Cleaving Protein 1 (BACE1)

(2012) Yingjun Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis

(2012) Sune Skeldal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hippocampal ProNGF Signaling Pathways and β-Amyloid Levels in Mild Cognitive Impairment and Alzheimer Disease

(2012) Elliott J. Mufson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Intracellular Amyloid Precursor Protein Sorting and Amyloid-  Secretion Are Regulated by Src-Mediated Phosphorylation of Mint2

(2012) J. Chaufty et al.   JOURNAL OF NEUROSCIENCE

Adaptor protein 2–mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing

(2012) Yogikala Prabhu et al.   MOLECULAR BIOLOGY OF THE CELL

GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production

(2012) Jeremy H. Herskowitz et al.   MOLECULAR BIOLOGY OF THE CELL

LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer’s disease

(2012) Julie Brodeur et al.   Molecular Neurodegeneration

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing

(2012) Yonghao Zhao et al.   Molecular Neurodegeneration

Membrane Trafficking Pathways in Alzheimer's Disease

(2012) Lawrence Rajendran et al.   TRAFFIC

p75 neurotrophin receptor signaling in nervous system injury and degeneration: paradox and opportunity

(2012) Carlos F. Ibáñez et al.   TRENDS IN NEUROSCIENCES

Roles of p75NTR in the pathogenesis of Alzheimer's disease: A novel therapeutic target

(2011) Fan Zeng et al.   BIOCHEMICAL PHARMACOLOGY

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

(2011) Sascha W Weyer et al.   EMBO JOURNAL

Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling

(2011) Xuan Xu et al.   EMBO REPORTS

Intracellular trafficking of the β-secretase and processing of amyloid precursor protein

(2011) Pei Zhi et al.   IUBMB LIFE

BACE1 Retrograde Trafficking Is Uniquely Regulated by the Cytoplasmic Domain of Sortilin

(2011) Gina M. Finan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology

(2011) Lei Wen et al.   JOURNAL OF CELL BIOLOGY

The physiology of the β-amyloid precursor protein intracellular domain AICD

(2011) Raphaëlle Pardossi-Piquard et al.   JOURNAL OF NEUROCHEMISTRY

p75NTR Regulates A  Deposition by Increasing A  Production But Inhibiting A  Aggregation with Its Extracellular Domain

(2011) Y.-J. Wang et al.   JOURNAL OF NEUROSCIENCE

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

(2011) R. Sannerud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Does the term ‘trophic’ actually mean anti-amyloidogenic? The case of NGF

(2010) P Calissano et al.   CELL DEATH AND DIFFERENTIATION

The Upside of APP at Synapses

(2010) Hyang-Sook Hoe et al.   CNS Neuroscience & Therapeutics

Sorting of the Alzheimer's Disease Amyloid Precursor Protein Mediated by the AP-4 Complex

(2010) Patricia V. Burgos et al.   DEVELOPMENTAL CELL

Nerve growth factor as a paradigm of neurotrophins related to Alzheimer's disease

(2010) P. Calissano et al.   Developmental Neurobiology

Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing

(2010) Hirokazu Okada et al.   FASEB JOURNAL

Neurotrophic factors in Alzheimer’s disease: role of axonal transport

(2010) K. Schindowski et al.   GENES BRAIN AND BEHAVIOR

BACE: Therapeutic target and potential biomarker for Alzheimer's disease

(2010) Geneviève Evin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a β-Secretase-dependent Pathway

(2010) Nikolai D. Belyaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dab1 binds to Fe65 and diminishes the effect of Fe65 or LRP1 on APP processing

(2010) Oh Yeun Kwon et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Phosphorylation of APP-CTF-AICD domains and interaction with adaptor proteins: signal transduction and/or transcriptional role - relevance for Alzheimer pathology

(2010) Gennaro Schettini et al.   JOURNAL OF NEUROCHEMISTRY

Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain

(2010) Maho Kondo et al.   Molecular Neurodegeneration

Preservation of cortical sortilin protein levels in MCI and Alzheimer's disease

(2010) Elliott J. Mufson et al.   NEUROSCIENCE LETTERS

Selective vulnerability in Alzheimer's disease: Amyloid precursor protein and p75NTRinteraction

(2009) Joanna Fombonne et al.   ANNALS OF NEUROLOGY

The proNGF-p75NTR-Sortilin Signalling Complex as New Target for the Therapeutic Treatment of Parkinsons Disease

(2009) L. Chen et al.   CNS & Neurological Disorders-Drug Targets

Enhanced spatial memory and hippocampal long-term potentiation in p75 neurotrophin receptor knockout mice

(2009) Graham L. Barrett et al.   HIPPOCAMPUS

The  -Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

(2009) R. Vassar et al.   JOURNAL OF NEUROSCIENCE

The p75 Neurotrophin Receptor Promotes Amyloid- (1-42)-Induced Neuritic Dystrophy In Vitro and In Vivo

(2009) J. K. Knowles et al.   JOURNAL OF NEUROSCIENCE

The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains

(2009) Robert Tamayev et al.   Molecular Neurodegeneration

A Novel Sorting Nexin Modulates Endocytic Trafficking and α-Secretase Cleavage of the Amyloid Precursor Protein

(2008) Susanne Schöbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adaptor Protein Sorting Nexin 17 Regulates Amyloid Precursor Protein Trafficking and Processing in the Early Endosomes

(2008) Jiyeon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing

(2008) Takashi Sakurai et al.   JOURNAL OF CELL BIOLOGY

 -Amyloid1-42 Induces Neuronal Death through the p75 Neurotrophin Receptor

(2008) A. Sotthibundhu et al.   JOURNAL OF NEUROSCIENCE

The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics—Relevance for Alzheimer's disease

(2008) Thorsten Müller et al.   PROGRESS IN NEUROBIOLOGY

Mint3/X11γ Is an ADP-Ribosylation Factor-dependent Adaptor that Regulates the Traffic of the Alzheimer's Precursor Protein from the Trans-Golgi Network

(2007) Punya Shrivastava-Ranjan et al.   MOLECULAR BIOLOGY OF THE CELL