GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates Aβ production

Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b- and AP4-dependent pathway

(2017) Wei Hong Toh et al.   TRAFFIC

Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1

(2017) Na-Young Kim et al.   Alzheimers Research & Therapy

Dysregulation of intracellular trafficking and endosomal sorting in Alzheimer's disease: controversies and unanswered questions

(2016) W. H. Toh et al.   BIOCHEMICAL JOURNAL

Mononuclear, Dinuclear, and Trinuclear Iron Complexes Featuring a New Monoanionic SNS Thiolate Ligand

(2016) Uttam K. Das et al.   INORGANIC CHEMISTRY

A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex

(2016) Thomas Clairfeuille et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex

(2016) Thomas Clairfeuille et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Early etiology of Alzheimer’s disease: tipping the balance toward autophagy or endosomal dysfunction?

(2015) Aleksandar Peric et al.   ACTA NEUROPATHOLOGICA

Retromer and sorting nexins in endosomal sorting

(2015) Matthew Gallon et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Retromer in Alzheimer disease, Parkinson disease and other neurological disorders

(2015) Scott A. Small et al.   NATURE REVIEWS NEUROSCIENCE

Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase

(2014) Virginie Buggia-Prévot et al.   Molecular Neurodegeneration

Dysregulation of protein trafficking in neurodegeneration

(2014) Xin Wang et al.   Molecular Neurodegeneration

Pharmacological chaperones stabilize retromer to limit APP processing

(2014) Vincent J Mecozzi et al.   Nature Chemical Biology

The Use of Pharmacological Retromer Chaperones in Alzheimer’s Disease and other Endosomal-related Disorders

(2014) Diego E. Berman et al.   Neurotherapeutics

A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer

(2014) M. Gallon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane-associated cargo recycling by tubule-based endosomal sorting

(2014) Jan R.T. van Weering et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

High-Throughput Quantitation of Intracellular Trafficking and Organelle Disruption by Flow Cytometry

(2014) Pei Zhi Cheryl Chia et al.   TRAFFIC

A Paired RNAi and RabGAP Overexpression Screen Identifies Rab11 as a Regulator of β-Amyloid Production

(2014) Vinod Udayar et al.   Cell Reports

A Function for EHD Family Proteins in Unidirectional Retrograde Dendritic Transport of BACE1 and Alzheimer’s Disease Aβ Production

(2014) Virginie Buggia-Prévot et al.   Cell Reports

Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway

(2013) Utpal Das et al.   NEURON

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

(2013) R. Ghai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular Itinerary of Internalised β-Secretase, BACE1, and Its Potential Impact on β-Amyloid Peptide Biogenesis

(2013) Pei Zhi Cheryl Chia et al.   TRAFFIC

Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine - searching for the connections

(2012) Wojciech Danysz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adaptor protein 2–mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing

(2012) Yogikala Prabhu et al.   MOLECULAR BIOLOGY OF THE CELL

GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production

(2012) Jeremy H. Herskowitz et al.   MOLECULAR BIOLOGY OF THE CELL

Tracking protein aggregation and mislocalization in cells with flow cytometry

(2012) Yasmin M Ramdzan et al.   NATURE METHODS

Getting active: protein sorting in endocytic recycling

(2012) Victor W. Hsu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of Alzheimer disease-associated variants in genes that regulate retromer function

(2012) Badri N. Vardarajan et al.   NEUROBIOLOGY OF AGING

Retromers in Alzheimer’s Disease

(2012) Barbara M. Siegenthaler et al.   Neurodegenerative Diseases

Retromer Guides STxB and CD8-M6PR from Early to Recycling Endosomes, EHD1 Guides STxB from Recycling Endosome to Golgi

(2012) Jenna E. McKenzie et al.   TRAFFIC

SNX5 is essential for efficient macropinocytosis and antigen processing in primary macrophages

(2012) J. P. Lim et al.   Biology Open

BACE1 Retrograde Trafficking Is Uniquely Regulated by the Cytoplasmic Domain of Sortilin

(2011) Gina M. Finan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology

(2011) Lei Wen et al.   JOURNAL OF CELL BIOLOGY

Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease

(2011) Stephen D. Ginsberg et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Sorting nexins provide diversity for retromer-dependent trafficking events

(2011) Peter J. Cullen et al.   NATURE CELL BIOLOGY

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

(2011) Adam W Bero et al.   NATURE NEUROSCIENCE

Retromer disruption promotes amyloidogenic APP processing

(2011) Christopher P. Sullivan et al.   NEUROBIOLOGY OF DISEASE

Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27

(2011) B. Balana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transport at the recycling endosome

(2010) Victor W Hsu et al.   CURRENT OPINION IN CELL BIOLOGY

Sorting of the Alzheimer's Disease Amyloid Precursor Protein Mediated by the AP-4 Complex

(2010) Patricia V. Burgos et al.   DEVELOPMENTAL CELL

Ubiquitin Regulates GGA3-mediated Degradation of BACE1

(2010) Eugene L. Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated

(2010) Sandra I Vieira et al.   Molecular Neurodegeneration

Rapid and Direct Transport of Cell Surface APP to the Lysosome defines a novel selective pathway

(2010) Angela Lorenzen et al.   Molecular Brain

Automated organelle-based colocalization in whole-cell imaging

(2009) Ben J. Woodcroft et al.   CYTOMETRY PART A

The Retromer Coat Complex Coordinates Endosomal Sorting and Dynein-Mediated Transport, with Carrier Recognition by the trans-Golgi Network

(2009) Thomas Wassmer et al.   DEVELOPMENTAL CELL

S655 phosphorylation enhances APP secretory traffic

(2009) Sandra Isabel Vieira et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Subcellular targeting strategies for drug design and delivery

(2009) Lawrence Rajendran et al.   NATURE REVIEWS DRUG DISCOVERY

Pathways and mechanisms of endocytic recycling

(2009) Barth D. Grant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Analysis of Articulation Between Clathrin and Retromer in Retrograde Sorting on Early Endosomes

(2009) Vincent Popoff et al.   TRAFFIC

Inhibition of γ-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

(2008) Robyn A. Sharples et al.   FASEB JOURNAL

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and A  accumulation

(2008) A. Muhammad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure and Function of the Retromer Protein Complex

(2008) Brett M. Collins   TRAFFIC