Trial Watch—Small molecules targeting the immunological tumor microenvironment for cancer therapy
出版年份 2016 全文链接
标题
Trial Watch—Small molecules targeting the immunological tumor microenvironment for cancer therapy
作者
关键词
-
出版物
OncoImmunology
Volume 5, Issue 6, Pages e1149674
出版商
Informa UK Limited
发表日期
2016-03-11
DOI
10.1080/2162402x.2016.1149674
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Idelalisib
- (2015) Arpita Shah et al. ANNALS OF PHARMACOTHERAPY
- Lenalidomide, idelalisib, and rituximab are unacceptably toxic in patients with relapsed/refractory indolent lymphoma
- (2015) C. Y. Cheah et al. BLOOD
- Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy
- (2015) B.-S. Cho et al. BLOOD
- Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition
- (2015) Stephen Mok et al. BMC CANCER
- Macrophages and Therapeutic Resistance in Cancer
- (2015) Brian Ruffell et al. CANCER CELL
- Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents
- (2015) Lorenzo Galluzzi et al. CANCER CELL
- Phase 1 study of galunisertib, a TGF-beta receptor I kinase inhibitor, in Japanese patients with advanced solid tumors
- (2015) Yutaka Fujiwara et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Bone marrow derived myeloid cells orchestrate antiangiogenic resistance in glioblastoma through coordinated molecular networks
- (2015) B.R. Achyut et al. CANCER LETTERS
- Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages
- (2015) C. Frankenberger et al. CANCER RESEARCH
- Macrophage Blockade Using CSF1R Inhibitors Reverses the Vascular Leakage Underlying Malignant Ascites in Late-Stage Epithelial Ovarian Cancer
- (2015) D. L. Moughon et al. CANCER RESEARCH
- Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity
- (2015) Santiago Zelenay et al. CELL
- Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
- (2015) Padmanee Sharma et al. CELL
- Tadalafil Augments Tumor Specific Immunity in Patients with Head and Neck Squamous Cell Carcinoma
- (2015) J. A. Califano et al. CLINICAL CANCER RESEARCH
- Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy
- (2015) L. Zhai et al. CLINICAL CANCER RESEARCH
- The efficacy of oral adenosine A2Aantagonist istradefylline for the treatment of moderate to severe Parkinson’s disease
- (2015) Ruxandra Julia Vorovenci et al. Expert Review of Neurotherapeutics
- Involvement of purinergic system in the release of cytokines by macrophages exposed to glioma-conditioned medium
- (2015) Letícia Scussel Bergamin et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited
- (2015) Luke Boulter et al. JOURNAL OF CLINICAL INVESTIGATION
- VEGF-A modulates expression of inhibitory checkpoints on CD8+T cells in tumors
- (2015) Thibault Voron et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Intratumoral Delivery of IL-21 Overcomes Anti-Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype
- (2015) Meng Xu et al. JOURNAL OF IMMUNOLOGY
- Prostaglandin E2Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages
- (2015) Milena Sokolowska et al. JOURNAL OF IMMUNOLOGY
- Hypoxia/Reoxygenation Inhibits P2Y11 Receptor Expression and Its Immunosuppressive Activity in Human Dendritic Cells
- (2015) Stéphanie Chadet et al. JOURNAL OF IMMUNOLOGY
- α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5′-Nucleotidase (CD73) Inhibitors
- (2015) Sanjay Bhattarai et al. JOURNAL OF MEDICINAL CHEMISTRY
- Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
- (2015) Christina Twyman-Saint Victor et al. NATURE
- Natural and therapy-induced immunosurveillance in breast cancer
- (2015) Guido Kroemer et al. NATURE MEDICINE
- Kinase inhibitors and monoclonal antibodies in oncology: clinical implications
- (2015) Helen Gharwan et al. Nature Reviews Clinical Oncology
- Combination cancer immunotherapies tailored to the tumour microenvironment
- (2015) Mark J. Smyth et al. Nature Reviews Clinical Oncology
- Pioneering government-sponsored drug repositioning collaborations: progress and learning
- (2015) Donald E. Frail et al. NATURE REVIEWS DRUG DISCOVERY
- Tackling reproducibility in academic preclinical drug discovery
- (2015) Stephen V. Frye et al. NATURE REVIEWS DRUG DISCOVERY
- Big opportunities for small molecules in immuno-oncology
- (2015) Jerry L. Adams et al. NATURE REVIEWS DRUG DISCOVERY
- Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study
- (2015) Nicholas Butowski et al. NEURO-ONCOLOGY
- Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor
- (2015) William D. Tap et al. NEW ENGLAND JOURNAL OF MEDICINE
- CXCR4 pharmacogical inhibition reduces bone and soft tissue metastatic burden by affecting tumor growth and tumorigenic potential in prostate cancer preclinical models
- (2015) Giovanni Luca Gravina et al. PROSTATE
- The future of immune checkpoint therapy
- (2015) P. Sharma et al. SCIENCE
- Radiotherapy and Immunogenic Cell Death
- (2015) Encouse B. Golden et al. SEMINARS IN RADIATION ONCOLOGY
- Nitric oxide synthase in innate and adaptive immunity: an update
- (2015) Christian Bogdan TRENDS IN IMMUNOLOGY
- Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway
- (2015) Michael Lahn et al. Drug Design Development and Therapy
- Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model
- (2015) Claudia Sorrentino et al. Oncotarget
- Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway
- (2015) Manoj K. Kashyap et al. Oncotarget
- Autophagy is involved in TGF-β1-induced protective mechanisms and formation of cancer-associated fibroblasts phenotype in tumor microenvironment
- (2015) Fang-Lan Liu et al. Oncotarget
- POL5551, a novel and potent CXCR4 antagonist, enhances sensitivity to chemotherapy in pediatric ALL
- (2015) Edward Allan R. Sison et al. Oncotarget
- The efficacy of oral adenosine A2Aantagonist istradefylline for the treatment of moderate to severe Parkinson’s disease
- (2015) Ruxandra Julia Vorovenci et al. Expert Review of Neurotherapeutics
- Preladenant as an Adjunctive Therapy With Levodopa in Parkinson Disease
- (2015) Robert A. Hauser et al. JAMA Neurology
- T H 2-Polarized CD4 + T Cells and Macrophages Limit Efficacy of Radiotherapy
- (2015) Stephen L. Shiao et al. Cancer Immunology Research
- The effect of CCR2 inhibitor CCX140-B on residual albuminuria in patients with type 2 diabetes and nephropathy: a randomised trial
- (2015) Dick de Zeeuw et al. Lancet Diabetes & Endocrinology
- Increased sMICA and TGFβ1levels in HNSCC patients impair NKG2D-dependent functionality of activated NK cells
- (2015) Stephan Klöß et al. OncoImmunology
- Mast cell/MDSC a liaison immunosuppressive for tumor microenvironment
- (2015) Luca Danelli et al. OncoImmunology
- Metronomic cyclophosphamide eradicates large implanted GL261 gliomas by activating antitumor Cd8+T-cell responses and immune memory
- (2015) Junjie Wu et al. OncoImmunology
- CD73: A potential biomarker for anti-PD-1 therapy
- (2015) Paul A Beavis et al. OncoImmunology
- Natural killer cell mediated immunosurveillance of pediatric neuroblastoma
- (2015) Michaela Semeraro et al. OncoImmunology
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- (2015) Diletta Di Mitri et al. OncoImmunology
- CD39: A complementary target to immune checkpoints to counteract tumor-mediated immunosuppression
- (2015) Nathalie Bonnefoy et al. OncoImmunology
- Expression profile of the human IDO1 protein, a cancer drug target involved in tumoral immune resistance
- (2015) Nathalie Vigneron et al. OncoImmunology
- Characterization of the myeloid-derived suppressor cell subset regulated by NK cells in malignant lymphoma
- (2015) Yusuke Sato et al. OncoImmunology
- Histamine deficiency promotes accumulation of immunosuppressive immature myeloid cells and growth of murine gliomas
- (2015) Brian Ahn et al. OncoImmunology
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- (2015) Erika Vacchelli et al. OncoImmunology
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- (2015) Daniel Gonnermann et al. OncoImmunology
- Kynurenine and uric acid levels in chronic myeloid leukemia patients
- (2015) Vladimir Vonka et al. OncoImmunology
- Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications
- (2015) Aitziber Buqué et al. OncoImmunology
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- (2015) Guido Kroemer et al. OncoImmunology
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- (2015) Jonathan Pol et al. OncoImmunology
- Myeloid derived suppressor cells—An overview of combat strategies to increase immunotherapy efficacy
- (2015) Oana Draghiciu et al. OncoImmunology
- Consensus nomenclature for CD8+T cell phenotypes in cancer
- (2015) Lionel Apetoh et al. OncoImmunology
- COX-2 promotes metastasis in nasopharyngeal carcinoma by mediating interactions between cancer cells and myeloid-derived suppressor cells
- (2015) Ze-Lei Li et al. OncoImmunology
- Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells
- (2015) Annie A Wu et al. OncoImmunology
- Idelalisib- a PI3Kδ targeting agent for B-cell malignancies
- (2015) Yvonne G Hewett et al. JOURNAL OF ONCOLOGY PHARMACY PRACTICE
- Plerixafor as a chemosensitizing agent in pediatric acute lymphoblastic leukemia: efficacy and potential mechanisms of resistance to CXCR4 inhibition
- (2015) Edward Allan R. Sison et al. Oncotarget
- Macrophages are recruited to hypoxic tumor areas and acquire a Pro-Angiogenic M2-Polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin
- (2015) Chakrapani Tripathi et al. Oncotarget
- A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors
- (2015) Hatem H. Soliman et al. Oncotarget
- Blockade of A2b Adenosine Receptor Reduces Tumor Growth and Immune Suppression Mediated by Myeloid-Derived Suppressor Cells in a Mouse Model of Melanoma
- (2015) Raffaella Iannone et al. NEOPLASIA
- Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110 , for relapsed/refractory chronic lymphocytic leukemia
- (2014) J. R. Brown et al. BLOOD
- Idelalisib, a selective inhibitor of phosphatidylinositol 3-kinase- , as therapy for previously treated indolent non-Hodgkin lymphoma
- (2014) I. W. Flinn et al. BLOOD
- A phase 1 study of the PI3K inhibitor idelalisib in patients with relapsed/refractory mantle cell lymphoma (MCL)
- (2014) B. S. Kahl et al. BLOOD
- Combination of an agonistic anti-CD40 monoclonal antibody and the COX-2 inhibitor celecoxib induces anti-glioma effects by promotion of type-1 immunity in myeloid cells and T-cells
- (2014) Akemi Kosaka et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Abstract 491: NLG919, a novel indoleamine-2,3-dioxygenase (IDO)-pathway inhibitor drug candidate for cancer therapy.
- (2014) Mario R. Mautino et al. CANCER RESEARCH
- Myeloid Expression of Adenosine A2A Receptor Suppresses T and NK Cell Responses in the Solid Tumor Microenvironment
- (2014) C. Cekic et al. CANCER RESEARCH
- Antimetastatic Effects of Blocking PD-1 and the Adenosine A2A Receptor
- (2014) D. Mittal et al. CANCER RESEARCH
- Prostaglandin E2 receptor EP4 as the common target on cancer cells and macrophages to abolish angiogenesis, lymphangiogenesis, metastasis, and stem-like cell functions
- (2014) Mousumi Majumder et al. CANCER SCIENCE
- Cardiac Safety of TGF-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Cancer Patients in a First-in-Human Dose Study
- (2014) Richard J. Kovacs et al. Cardiovascular Toxicology
- Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
- (2014) L Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- Tadalafil Reduces Myeloid-Derived Suppressor Cells and Regulatory T Cells and Promotes Tumor Immunity in Patients with Head and Neck Squamous Cell Carcinoma
- (2014) D. T. Weed et al. CLINICAL CANCER RESEARCH
- First-in-Human Dose Study of the Novel Transforming Growth Factor-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Patients with Advanced Cancer and Glioma
- (2014) Jordi Rodon et al. CLINICAL CANCER RESEARCH
- Sustained Inhibition of Receptor Tyrosine Kinases and Macrophage Depletion by PLX3397 and Rapamycin as a Potential New Approach for the Treatment of MPNSTs
- (2014) P. P. Patwardhan et al. CLINICAL CANCER RESEARCH
- Inhibition of Tumor-Derived Prostaglandin-E2 Blocks the Induction of Myeloid-Derived Suppressor Cells and Recovers Natural Killer Cell Activity
- (2014) Y. Mao et al. CLINICAL CANCER RESEARCH
- Durable Therapeutic Efficacy Utilizing Combinatorial Blockade against IDO, CTLA-4, and PD-L1 in Mice with Brain Tumors
- (2014) D. A. Wainwright et al. CLINICAL CANCER RESEARCH
- Chronic lymphocytic leukemia nurse-like cells express hepatocyte growth factor receptor (c-MET) and indoleamine 2,3-dioxygenase and display features of immunosuppressive type 2 skewed macrophages
- (2014) P. Giannoni et al. HAEMATOLOGICA
- Potential for Developing Purinergic Drugs for Gastrointestinal Diseases
- (2014) Fernando Ochoa-Cortes et al. INFLAMMATORY BOWEL DISEASES
- Adenosine Receptors: Expression, Function and Regulation
- (2014) Sandeep Sheth et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Pharmacokinetic, pharmacodynamic and biomarker evaluation of transforming growth factor-β receptor I kinase inhibitor, galunisertib, in phase 1 study in patients with advanced cancer
- (2014) Jordi Rodón et al. INVESTIGATIONAL NEW DRUGS
- Disruption of CCR5-Dependent Homing of Regulatory T Cells Inhibits Tumor Growth in a Murine Model of Pancreatic Cancer
- (2014) M. C. B. Tan et al. JOURNAL OF IMMUNOLOGY
- Noncanonical NF-κB Activation Mediates STAT3-Stimulated IDO Upregulation in Myeloid-Derived Suppressor Cells in Breast Cancer
- (2014) Jinpu Yu et al. JOURNAL OF IMMUNOLOGY
- Adenosine A2B receptor antagonist PSB603 suppresses tumor growth and metastasis by inhibiting induction of regulatory T cells
- (2014) Wakako Kaji et al. JOURNAL OF TOXICOLOGICAL SCIENCES
- Pten Null Prostate Epithelium Promotes Localized Myeloid-Derived Suppressor Cell Expansion and Immune Suppression during Tumor Initiation and Progression
- (2014) A. J. Garcia et al. MOLECULAR AND CELLULAR BIOLOGY
- Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer
- (2014) Khaled Ali et al. NATURE
- Organelle-specific initiation of cell death
- (2014) Lorenzo Galluzzi et al. NATURE CELL BIOLOGY
- Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2
- (2014) Alastair J O'Brien et al. NATURE MEDICINE
- Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors
- (2014) Gregory T Motz et al. NATURE MEDICINE
- Novel antiplatelet agents in acute coronary syndrome
- (2014) Francesco Franchi et al. Nature Reviews Cardiology
- Current and emerging strategies for the prevention of graft-versus-host disease
- (2014) Sung Won Choi et al. Nature Reviews Clinical Oncology
- PI3K and cancer: lessons, challenges and opportunities
- (2014) David A. Fruman et al. NATURE REVIEWS DRUG DISCOVERY
- Mechanisms, impact and management of pain in rheumatoid arthritis
- (2014) David A. Walsh et al. Nature Reviews Rheumatology
- PI3Kδ Inhibition by Idelalisib in Patients with Relapsed Indolent Lymphoma
- (2014) Ajay K. Gopal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Idelalisib and Rituximab in Relapsed Chronic Lymphocytic Leukemia
- (2014) Richard R. Furman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Amino Acids and Immune Response: A Role for Cysteine, Glutamine, Phenylalanine, Tryptophan and Arginine in T-cell Function and Cancer?
- (2014) Angelos K. Sikalidis PATHOLOGY & ONCOLOGY RESEARCH
- Phase I Study of GC1008 (Fresolimumab): A Human Anti-Transforming Growth Factor-Beta (TGFβ) Monoclonal Antibody in Patients with Advanced Malignant Melanoma or Renal Cell Carcinoma
- (2014) John C. Morris et al. PLoS One
- Inhibition of CSF-1R Supports T-Cell Mediated Melanoma Therapy
- (2014) Marjolein Sluijter et al. PLoS One
- ATP/P2X7 axis modulates myeloid-derived suppressor cell functions in neuroblastoma microenvironment
- (2014) G Bianchi et al. Cell Death & Disease
- Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation
- (2014) Hongmei Fu et al. Nature Communications
- Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity
- (2014) J. Bastid et al. Cancer Immunology Research
- Regulation of Macrophage Polarization by RON Receptor Tyrosine Kinase Signaling
- (2014) Amitabha Chaudhuri Frontiers in Immunology
- CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+T cells
- (2014) Debbie C Strachan et al. OncoImmunology
- Novel immune checkpoint blocker approved for the treatment of advanced melanoma
- (2014) Lorenzo Galluzzi et al. OncoImmunology
- An autophagy-dependent anticancer immune response determines the efficacy of melanoma chemotherapy
- (2014) Mickaël Michaud et al. OncoImmunology
- Novel insights into the mechanism of action of lenalidomide
- (2014) Michaela Semeraro et al. OncoImmunology
- Immunosurveillance of senescent cancer cells by natural killer cells
- (2014) Alexandre Iannello et al. OncoImmunology
- Chemotherapy engages multiple pathways leading to IL-1β production by myeloid leukocytes
- (2014) Christina Antonopoulos et al. OncoImmunology
- Chemokines and chemokine receptors required for optimal responses to anticancer chemotherapy
- (2014) Yuting Ma et al. OncoImmunology
- Tumor-infiltrating lymphocytes in breast cancer
- (2014) Yasmin Issa-Nummer et al. OncoImmunology
- T cell immunosurveillance controls B lymphoma development
- (2014) Axel Kallies OncoImmunology
- Targeting the adenosine A2b receptor in the tumor microenvironment overcomes local immunosuppression by myeloid-derived suppressor cells
- (2014) Silvana Morello et al. OncoImmunology
- Synergistic antitumor effects of a TGFβ inhibitor and cyclophosphamide
- (2014) Xin Chen et al. OncoImmunology
- Sarcoma response to targeted therapy dynamically polarizes tumor-associated macrophages
- (2014) Michael J Cavnar et al. OncoImmunology
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- (2014) Fernando Aranda et al. OncoImmunology
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- (2014) Nicola Hardwick et al. OncoImmunology
- Ménage à trois
- (2014) Derek A Wainwright et al. OncoImmunology
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- (2014) Norma Bloy et al. OncoImmunology
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- (2014) Irena Adkins et al. OncoImmunology
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- (2014) Arabella Young et al. OncoImmunology
- Tumor-infiltrating lymphocytes favor the response to chemoradiotherapy of head and neck cancer
- (2014) Panagiotis Balermpas et al. OncoImmunology
- AMD3100 protects from UV-induced skin cancer
- (2014) Scott N Byrne et al. OncoImmunology
- Abscopal effects of radiotherapy on advanced melanoma patients who progressed after ipilimumab immunotherapy
- (2014) Antonio M Grimaldi et al. OncoImmunology
- Notch and TGFβ
- (2014) Hidetaka Ohnuki et al. OncoImmunology
- The hedgehog’s trick for escaping immunosurveillance
- (2014) Jingwu Xie OncoImmunology
- Tumor-infiltrating T-cells: important players in clinical outcome of advanced melanoma patients
- (2014) Esther P M Tjin et al. OncoImmunology
- Immune checkpoints
- (2014) Akhil Chawla et al. OncoImmunology
- Trial Watch
- (2014) Fernando Aranda et al. OncoImmunology
- The pancreatic cancer microenvironment: an immunologic battleground
- (2014) Venu G Pillarisetty OncoImmunology
- Trial watch
- (2014) Erika Vacchelli et al. OncoImmunology
- Two is better than one: Complementing oncolytic virotherapy with gemcitabine to potentiate antitumor immune responses
- (2014) Shashi Gujar et al. OncoImmunology
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- (2013) Minoru Tanaka et al. BIOORGANIC & MEDICINAL CHEMISTRY
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- (2013) Joanna Lecka et al. BRITISH JOURNAL OF PHARMACOLOGY
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- (2013) Thomas F Gajewski et al. NATURE IMMUNOLOGY
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- (2013) Stephanie M Pyonteck et al. NATURE MEDICINE
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- (2013) Jordi Rodon et al. Nature Reviews Clinical Oncology
- Adenosine receptors as drug targets — what are the challenges?
- (2013) Jiang-Fan Chen et al. NATURE REVIEWS DRUG DISCOVERY
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- (2013) N Weizman et al. ONCOGENE
- A randomized, double-blind, placebo-controlled trial of a chemokine receptor 2 (CCR2) antagonist in posttraumatic neuralgia
- (2013) Jarkko Kalliomäki et al. PAIN
- Maraviroc, a CCR5 Antagonist, Prevents Development of Hepatocellular Carcinoma in a Mouse Model
- (2013) Laura Ochoa-Callejero et al. PLoS One
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- (2013) Mabel Ryder et al. PLoS One
- Blockade of A2Areceptors potently suppresses the metastasis of CD73+tumors
- (2013) Paul A. Beavis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting CXCL12/CXCR4 signaling with oncolytic virotherapy disrupts tumor vasculature and inhibits breast cancer metastases
- (2013) M. Gil et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
- (2013) C. Feig et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An Adenosine-Mediated Signaling Pathway Suppresses Prenylation of the GTPase Rap1B and Promotes Cell Scattering
- (2013) E. Ntantie et al. Science Signaling
- CD39 and CD73 in immunity and inflammation
- (2013) Luca Antonioli et al. TRENDS IN MOLECULAR MEDICINE
- Small Molecule Inhibitors of CXCR4
- (2013) Bikash Debnath et al. Theranostics
- A prostaglandin E (PGE) receptor EP4 antagonist protects natural killer cells from PGE2-mediated immunosuppression and inhibits breast cancer metastasis
- (2013) Xinrong Ma et al. OncoImmunology
- IFN-γ–Driven IDO Production from Macrophages Protects IL-4Rα–Deficient Mice against Lethality during Schistosoma mansoni Infection
- (2012) Reena Rani et al. AMERICAN JOURNAL OF PATHOLOGY
- Immunogenic Cell Death in Cancer Therapy
- (2012) Guido Kroemer et al. Annual Review of Immunology
- Selectivity profiling of the novel EP2receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP2receptor
- (2012) Mark A Birrell et al. BRITISH JOURNAL OF PHARMACOLOGY
- Phase I/II trial of non-cytotoxic suramin in combination with weekly paclitaxel in metastatic breast cancer treated with prior taxanes
- (2012) Maryam B. Lustberg et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Metastatic melanoma patients treated with dendritic cell vaccination, Interleukin-2 and metronomic cyclophosphamide: results from a phase II trial
- (2012) Eva Ellebaek et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Effects of 1-methyltryptophan stereoisomers on IDO2 enzyme activity and IDO2-mediated arrest of human T cell proliferation
- (2012) Feng Qian et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- CCR5 Antagonist Blocks Metastasis of Basal Breast Cancer Cells
- (2012) M. Velasco-Velazquez et al. CANCER RESEARCH
- Importance of direct macrophage - Tumor cell interaction on progression of human glioma
- (2012) Yoshihiro Komohara et al. CANCER SCIENCE
- Development of novel CXCR4-based therapeutics
- (2012) Amnon Peled et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Tumor-Infiltrating Monocytic Myeloid-Derived Suppressor Cells Mediate CCR5-Dependent Recruitment of Regulatory T Cells Favoring Tumor Growth
- (2012) E. Schlecker et al. JOURNAL OF IMMUNOLOGY
- Inhibition of CD73 Improves B Cell-Mediated Anti-Tumor Immunity in a Mouse Model of Melanoma
- (2012) G. Forte et al. JOURNAL OF IMMUNOLOGY
- Modulation of Host Natural Killer Cell Functions in Breast Cancer via Prostaglandin E2 Receptors EP2 and EP4
- (2012) Dawn M. Holt et al. JOURNAL OF IMMUNOTHERAPY
- Effective inhibition of metastases and primary tumor growth with CTCE-9908 in esophageal cancer
- (2012) Astrid Drenckhan et al. JOURNAL OF SURGICAL RESEARCH
- Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials
- (2012) Annemijn M Algra et al. LANCET ONCOLOGY
- Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
- (2012) Hirokazu Matsushita et al. NATURE
- Cancer prevention by targeting angiogenesis
- (2012) Adriana Albini et al. Nature Reviews Clinical Oncology
- Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer
- (2012) Harald von Boehmer et al. NATURE REVIEWS DRUG DISCOVERY
- Blockade of Lymphocyte Chemotaxis in Visceral Graft-versus-Host Disease
- (2012) Ran Reshef et al. NEW ENGLAND JOURNAL OF MEDICINE
- Aspirin Use, TumorPIK3CAMutation, and Colorectal-Cancer Survival
- (2012) Xiaoyun Liao et al. NEW ENGLAND JOURNAL OF MEDICINE
- Development of a Unique Small Molecule Modulator of CXCR4
- (2012) Zhongxing Liang et al. PLoS One
- Regulation of COX2 Expression in Mouse Mammary Tumor Cells Controls Bone Metastasis and PGE2-Induction of Regulatory T Cell Migration
- (2012) John Karavitis et al. PLoS One
- Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase
- (2012) L. Pilotte et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CXCR4 Inhibitors: Tumor Vasculature and Therapeutic Challenges
- (2012) Filomena de Nigris et al. Recent Patents on Anti-Cancer Drug Discovery
- Crystal Structure of the Human Ecto-5′-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling
- (2012) Karen Knapp et al. STRUCTURE
- Indoleamine 2,3 dioxygenase and metabolic control of immune responses
- (2012) David H. Munn et al. TRENDS IN IMMUNOLOGY
- The development and immunosuppressive functions of CD4+ CD25+ FoxP3+ regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway
- (2012) Akio Ohta et al. Frontiers in Immunology
- Trial watch
- (2012) Laura Senovilla et al. OncoImmunology
- Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells
- (2011) N. Obermajer et al. BLOOD
- In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP2 receptor antagonist
- (2011) KJ af Forselles et al. BRITISH JOURNAL OF PHARMACOLOGY
- Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression
- (2011) Michael C. Schmid et al. CANCER CELL
- Prostaglandin E2 (PGE2) suppresses natural killer cell function primarily through the PGE2 receptor EP4
- (2011) Dawn Holt et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Prognostic and Predictive Impact of Intra- and Peritumoral Immune Infiltrates
- (2011) W. H. Fridman et al. CANCER RESEARCH
- CD73-Deficient Mice Have Increased Antitumor Immunity and Are Resistant to Experimental Metastasis
- (2011) J. Stagg et al. CANCER RESEARCH
- Monocytic CCR2+ Myeloid-Derived Suppressor Cells Promote Immune Escape by Limiting Activated CD8 T-cell Infiltration into the Tumor Microenvironment
- (2011) A. M. Lesokhin et al. CANCER RESEARCH
- PGE2-Induced CXCL12 Production and CXCR4 Expression Controls the Accumulation of Human MDSCs in Ovarian Cancer Environment
- (2011) N. Obermajer et al. CANCER RESEARCH
- COX-2 Blockade Suppresses Gliomagenesis by Inhibiting Myeloid-Derived Suppressor Cells
- (2011) M. Fujita et al. CANCER RESEARCH
- Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
- (2011) L Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- Antibody Targeting of TGF-β in Cancer Patients
- (2011) Scott Lonning et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Altered purinergic signaling in CD73-deficient mice inhibits tumor progression
- (2011) Gennady G. Yegutkin et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Adenosine promotes alternative macrophage activation via A2A and A2B receptors
- (2011) Balázs Csóka et al. FASEB JOURNAL
- CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice
- (2011) Long Wang et al. JOURNAL OF CLINICAL INVESTIGATION
- Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells
- (2011) Barbara Molon et al. JOURNAL OF EXPERIMENTAL MEDICINE
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- (2011) Maria Antonova et al. JOURNAL OF HEADACHE AND PAIN
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- (2011) A. Clayton et al. JOURNAL OF IMMUNOLOGY
- Regulation of Macrophage Arginase Expression and Tumor Growth by the Ron Receptor Tyrosine Kinase
- (2011) D. R. Sharda et al. JOURNAL OF IMMUNOLOGY
- Adenosinergic Regulation of the Expansion and Immunosuppressive Activity of CD11b+Gr1+ Cells
- (2011) S. Ryzhov et al. JOURNAL OF IMMUNOLOGY
- CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
- (2011) Bin-Zhi Qian et al. NATURE
- Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy
- (2011) Qian Huang et al. NATURE MEDICINE
- Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
- (2011) Vinod P Balachandran et al. NATURE MEDICINE
- Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice
- (2011) M. Michaud et al. SCIENCE
- Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion
- (2011) R. D. Schreiber et al. SCIENCE
- Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors
- (2011) Mark J. Anderton et al. TOXICOLOGIC PATHOLOGY
- Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy
- (2011) David G. DeNardo et al. Cancer Discovery
- PGE2 inhibits natural killer and γδ T cell cytotoxicity triggered by NKR and TCR through a cAMP-mediated PKA type I-dependent signaling
- (2010) Ludovic Martinet et al. BIOCHEMICAL PHARMACOLOGY
- Synthesis, SAR and evaluation of [1,4′]-bipiperidinyl-4-yl-imidazolidin-2-one derivatives as novel CCR5 antagonists
- (2010) David M. Rotstein et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity
- (2010) X. Liu et al. BLOOD
- COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function
- (2010) Joris D Veltman et al. BMC CANCER
- Phase I trial of non-cytotoxic suramin as a modulator of docetaxel and gemcitabine therapy in previously treated patients with non-small cell lung cancer
- (2010) Elaine T. Lam et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- CD73 on Tumor Cells Impairs Antitumor T-Cell Responses: A Novel Mechanism of Tumor-Induced Immune Suppression
- (2010) D. Jin et al. CANCER RESEARCH
- Antiangiogenic Agents Can Increase Lymphocyte Infiltration into Tumor and Enhance the Effectiveness of Adoptive Immunotherapy of Cancer
- (2010) R. K. Shrimali et al. CANCER RESEARCH
- CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model
- (2010) Saima Hassan et al. INTERNATIONAL JOURNAL OF CANCER
- Hydroxyamidine Inhibitors of Indoleamine-2,3-dioxygenase Potently Suppress Systemic Tryptophan Catabolism and the Growth of IDO-Expressing Tumors
- (2010) H. K. Koblish et al. MOLECULAR CANCER THERAPEUTICS
- Targeting Toll-like receptors: emerging therapeutics?
- (2010) Elizabeth J. Hennessy et al. NATURE REVIEWS DRUG DISCOVERY
- Apoptotic Cells Activate the "Phoenix Rising" Pathway to Promote Wound Healing and Tissue Regeneration
- (2010) F. Li et al. Science Signaling
- Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis
- (2009) Soo-Hong Min et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Spiropiperidine CCR5 antagonists
- (2009) David M. Rotstein et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy
- (2009) A. K. Azab et al. BLOOD
- Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy
- (2009) S. J. Priceman et al. BLOOD
- Human Follicular Lymphoma CD39+-Infiltrating T Cells Contribute to Adenosine-Mediated T Cell Hyporesponsiveness
- (2009) S. P. Hilchey et al. JOURNAL OF IMMUNOLOGY
- NF546 [4,4'-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene- , '-diphosphonic Acid) Tetrasodium Salt] Is a Non-Nucleotide P2Y11 Agonist and Stimulates Release of Interleukin-8 from Human Monocyte-Derived Dendritic Cells
- (2009) S. Meis et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors
- (2009) François Ghiringhelli et al. NATURE MEDICINE
- Imatinib and beyond—exploring the full potential of targeted therapy for CML
- (2009) Alfonso Quintás-Cardama et al. Nature Reviews Clinical Oncology
- Effects of CXCR4 antagonist CTCE-9908 on prostate tumor growth
- (2009) Stacy Porvasnik et al. PROSTATE
- Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary disease
- (2009) Riccardo Polosa et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Noncytotoxic suramin as a chemosensitizer in patients with advanced non-small-cell lung cancer: a phase II study
- (2008) M. A. Villalona-Calero et al. ANNALS OF ONCOLOGY
- Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction
- (2008) S. M. Devine et al. BLOOD
- Adenosine receptors in regulation of dendritic cell differentiation and function
- (2008) S. V. Novitskiy et al. BLOOD
- Antagonism of the prostaglandin E receptor EP4 inhibits metastasis and enhances NK function
- (2008) Namita Kundu et al. BREAST CANCER RESEARCH AND TREATMENT
- Phase I/II Trial of 5-Fluorouracil and a Noncytotoxic Dose Level of Suramin in Patients with Metastatic Renal Cell Carcinoma
- (2008) Saby George et al. Clinical Genitourinary Cancer
- Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase
- (2008) Alberto Molano et al. IMMUNOLOGY LETTERS
- Indoleamine 2,3-Dioxygenase Is the Anticancer Target for a Novel Series of Potent Naphthoquinone-Based Inhibitors
- (2008) Sanjeev Kumar et al. JOURNAL OF MEDICINAL CHEMISTRY
- A CXCR4 Antagonist CTCE-9908 Inhibits Primary Tumor Growth and Metastasis of Breast Cancer
- (2008) Eugene H. Huang et al. JOURNAL OF SURGICAL RESEARCH
- Biomimetic synthesis of the IDO inhibitors exiguamine A and B
- (2008) Matthew Volgraf et al. Nature Chemical Biology
- Subgroup Analyses of Maraviroc in Previously Treated R5 HIV-1 Infection
- (2008) Gerd Fätkenheuer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Progress in the discovery of selective, high affinity A2B adenosine receptor antagonists as clinical candidates
- (2008) Rao V. Kalla et al. Purinergic Signalling
- Structure-activity relationships of anthraquinone derivatives derived from bromaminic acid as inhibitors of ectonucleoside triphosphate diphosphohydrolases (E-NTPDases)
- (2008) Younis Baqi et al. Purinergic Signalling
- Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-β kinase antagonist, in mice
- (2007) Lorea Bueno et al. EUROPEAN JOURNAL OF CANCER
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