期刊
ONCOIMMUNOLOGY
卷 3, 期 5, 页码 -出版社
LANDES BIOSCIENCE
DOI: 10.4161/onci.29029
关键词
Notch; Tgf beta; tumor-infiltrating myeloid cells; head and neck tumors; tumor microenvironment; tumor progression
Cell signals integral to the tumor microenvironment influence cancer progression. Tumor-associated myeloid cells secrete pro-tumorigenic agents including, but not limited to, the potent cytokine transforming growth factor beta (TGF beta). We have discovered a network of extrinsic signals including delta-like 4 (Dll4), Notch and TGF beta, linking malignant cells and tumor-infiltrating myeloid cells, a nexus portending a clinically-relevant anticancer treatment.
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