Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes

Smad phospho-isoforms direct context-dependent TGF-β signaling

(2013) Koichi Matsuzaki   CYTOKINE & GROWTH FACTOR REVIEWS

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

Requirements of transcription factor Smad-dependent and -independent TGF-  signaling to control discrete T-cell functions

(2012) A.-D. Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Key role for ubiquitin protein modification in TGFβ signal transduction

(2012) Miriam De Boeck et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Synthesis and biological evaluation of 1-substituted-3-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

(2011) Cheng Hua Jin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Role of Smads in TGFβ signaling

(2011) Carl-Henrik Heldin et al.   CELL AND TISSUE RESEARCH

Exploring anti-TGF-β therapies in cancer and fibrosis

(2011) Lukas J. A. C. Hawinkels et al.   GROWTH FACTORS

Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-β Is Mediated by Suppression of Eomesodermin

(2011) Kenji Ichiyama et al.   IMMUNITY

T Cell Surveillance of Oncogene-Induced Prostate Cancer Is Impeded by T Cell-Derived TGF-β1 Cytokine

(2011) Moses K. Donkor et al.   IMMUNITY

The Kinases MEKK2 and MEKK3 Regulate Transforming Growth Factor-β-Mediated Helper T Cell Differentiation

(2011) Xing Chang et al.   IMMUNITY

Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice

(2011) Jennifer Nancy Hahn et al.   JOURNAL OF CLINICAL INVESTIGATION

Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation

(2011) Alexander Pedroza-Gonzalez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interferon-γ links ultraviolet radiation to melanomagenesis in mice

(2011) M. Raza Zaidi et al.   NATURE

Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling

(2011) Youn Sook Lee et al.   Nature Communications

Interferon   limits the effectiveness of melanoma peptide vaccines

(2010) H.-I. Cho et al.   BLOOD

TGF- -RI Kinase Inhibitor SD-208 Reduces the Development and Progression of Melanoma Bone Metastases

(2010) K. S. Mohammad et al.   CANCER RESEARCH

Smad2 Positively Regulates the Generation of Th17 Cells

(2010) Gustavo J. Martinez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smad2 and Smad3 Are Redundantly Essential for the TGF- -Mediated Regulation of Regulatory T Plasticity and Th1 Development

(2010) T. Takimoto et al.   JOURNAL OF IMMUNOLOGY

T-bet and Eomesodermin Are Required for T Cell-Mediated Antitumor Immune Responses

(2010) Y. Zhu et al.   JOURNAL OF IMMUNOLOGY

Human Th1 Cells That Express CD300a Are Polyfunctional and After Stimulation Up-Regulate the T-Box Transcription Factor Eomesodermin

(2010) Sriram Narayanan et al.   PLoS One

E3 ubiquitin ligases in T-cell tolerance

(2009) Magdalena Paolino et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cell-Intrinsic Transforming Growth Factor-β Signaling Mediates Virus-Specific CD8+ T Cell Deletion and Viral Persistence In Vivo

(2009) Roberto Tinoco et al.   IMMUNITY

Smad3 Differentially Regulates the Induction of Regulatory and Inflammatory T Cell Differentiation

(2009) Gustavo J. Martinez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

(2009) Fernando Cruz-Guilloty et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies

(2009) Marc Pellegrini et al.   NATURE MEDICINE

An Anti-Transforming Growth Factor   Antibody Suppresses Metastasis via Cooperative Effects on Multiple Cell Compartments

(2008) J.-S. Nam et al.   CANCER RESEARCH

Next Generation of Immunotherapy for Melanoma

(2008) John M. Kirkwood et al.   JOURNAL OF CLINICAL ONCOLOGY

Transforming growth factor-β in cutaneous melanoma

(2008) Delphine Javelaud et al.   Pigment Cell & Melanoma Research