Review
Immunology
Xianzhe Zhou, Guishan Jin, Junwen Zhang, Fusheng Liu
Summary: As an important part of the glioma immune microenvironment, glioma-associated macrophages (GAMs) play crucial roles in tumor cell resistance to chemotherapy and radiotherapy as well as glioma pathogenesis. Research on GAM polarization and mechanisms of recruitment in the tumor microenvironment has been increasing. Suppressing GAMs at their source is likely to yield better therapeutic outcomes. This article summarizes the origin and recruitment mechanism of GAMs, as well as the therapeutic implications of inhibiting GAMs, aiming to facilitate future glioma-related research and the development of more effective treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Mathilde Bied, William W. Ho, Florent Ginhoux, Camille Bleriot
Summary: Macrophages are both important regulators of tissue homeostasis and abundant in the tumor microenvironment (TME), where they seem to support tumor development. However, tumor-associated macrophages (TAMs) exhibit vast heterogeneity and their associated functions have only recently been uncovered. This review outlines the various TAM populations identified thus far and their specialized roles in different stages of cancer progression. The article also discusses how macrophages may prime the premetastatic niche to facilitate metastasis and how subsequent metastasis-associated macrophages can support secondary tumor growth. Finally, the challenges in TAM research are addressed.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Oncology
Nan Xiao, Xiaodong Zhu, Kangshuai Li, Yifan Chen, Xuefeng Liu, Bin Xu, Ming Lei, Jiejie Xu, Hui-Chuan Sun
Summary: This study found that Siglec-10(hi) TAMs in HCC patients are associated with immune suppression and poor prognosis. Blocking Siglec-10 can enhance the anti-tumor effects of CD8(+) T cells and improve the efficacy of PD-1 inhibitors.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Review
Oncology
Liya Zhu, Xiu Juan Li, Prakash Gangadaran, Xiuli Jing, Byeong-Cheol Ahn
Summary: Macrophages play a significant role in the tumor microenvironment and have dual effects on the development of thyroid cancer. M1-like macrophages have cytotoxic effects on tumor cells and activate immune cells in the early stages of cancer, while M2-like macrophages promote tumor progression.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Lingli Long, Yue Hu, Tengfei Long, Xiaofang Lu, Ying Tuo, Yubing Li, Zunfu Ke
Summary: This study revealed a positive relationship between the formation of OvCa-TAMs spheroids and the malignancy of OvCa cells, with M2-TAMs inducing the epithelial-mesenchymal transition of OvCa cells through the release of CCL18. The overexpression of ZEB1 in OvCa cells in ovarian mice models promoted the formation of OvCa-TAMs spheroids in ascites, leading to faster transcoelomic metastasis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Pharmacology & Pharmacy
Mahboubeh Tajaldini, Mohsen Saeedi, Taghi Amiriani, Amir Hossein Amiriani, Sima Sedighi, Fatemeh Mohammad Zadeh, Mohammad Dehghan, Mehrdad Jahanshahi, Maziar Zanjan Ghandian, Pedram Khalili, Amir Houshang Poorkhani, Ali Mohammad Alizadeh, Vahid Khori
Summary: The tumor microenvironment (TME) plays a crucial role in cancer metastasis and drug resistance. Tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) regulate angiogenesis, tumor metastasis, and drug resistance by manipulating the composition and organization of extracellular matrix (ECM). Targeting TAMs and CAFs is essential for enhancing the effectiveness of anti-cancer agents.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Oncology
Xiaoxiao Li, Ling Chen, Xiaobo Peng, Xianbao Zhan
Summary: Tumor is a significant public health problem with high morbidity and mortality worldwide, with metastasis being the major contributor to patient deaths. Tumor-associated macrophages (TAMs) play a crucial role in the tumor microenvironment by interacting with tumor cells and influencing the EMT process of tumor cells.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Jennifer Sun, Chaelee Park, Nicole Guenthner, Shannon Gurley, Luna Zhang, Berit Lubben, Ola Adebayo, Hannah Bash, Yixuan Chen, Mina Maksimos, Barbara Muz, Abdel Kareem Azab
Summary: MM is a cancer of plasma cells in the bone marrow, with the tumor microenvironment playing a critical role in disease progression. TAMs in the TME have been found to support tumor survival and chemoresistance, highlighting the importance of exploring macrophage-targeted immunotherapy in MM treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Chunxiao Li, Xiaofei Xu, Shuhua Wei, Ping Jiang, Lixiang Xue, Junjie Wang
Summary: Macrophages play a crucial role in the tumor microenvironment, where they can be polarized into tumor-associated macrophages (TAMs). The abundance of TAMs in tumors is closely linked with poor prognosis, leading to investigations into therapeutic strategies targeting TAMs. These strategies include inhibiting macrophage recruitment to tumors, repolarizing TAMs towards an anti-tumor phenotype, and inducing macrophage-mediated destruction of cancer cells. As tumor immunotherapy gains more importance, new anti-tumor strategies focusing on TAMs are being discussed.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Yunzhou Pu, Qing Ji
Summary: This review summarizes the roles and mechanisms of tumor-associated macrophages (TAMs) in the resistance of PD-1/PD-L1 inhibitors. Various therapies, including inhibition of TAM differentiation and re-education of TAM activation, are available to recover the anticancer efficacy of PD-1/PD-L1 inhibitors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Roberto Coppo, Francesca Orso, Federico Virga, Alberto Dalmasso, Desiree Baruffaldi, Lei Nie, Fabiana Clapero, Daniela Dettori, Lorena Quirico, Elena Grassi, Paola Defilippi, Paolo Provero, Donatella Valdembri, Guido Serini, Mehran M. Sadeghi, Massimiliano Mazzone, Daniela Taverna
Summary: ESDN plays a critical role in melanoma progression by regulating the expression of E-selectin in endothelial cells, affecting melanoma cell adhesion, extravasation, and metastasis formation. The study proposes a protective role for ESDN in melanoma spread and highlights its therapeutic potential.
Article
Oncology
Melanie A. Dacheux, Sue Chin Lee, Yoojin Shin, Derek D. Norman, Kuan-Hung Lin, E. Shuyu, Junming Yue, Zoltan Benyo, Gabor J. Tigyi
Summary: This study investigates the role of autotaxin (ATX) produced by alveolar type II epithelial (ATII) pneumocytes in the progression of B16-F10 melanoma-derived lung metastases. The results show that ATX derived from ATII cells can affect the progression of lung metastasis by modulating cytokine levels and the infiltration of CD8(+) T cells.
Review
Oncology
Iva Truxova, David Cibula, Radek Spisek, Jitka Fucikova
Summary: Epithelial ovarian cancer (EOC) ranks among the top causes of cancer-related death in women due to early dissemination of malignant cells to the peritoneum. Despite improvements in medical therapies, EOC remains insensitive to immune checkpoint inhibitors, mainly due to a tumor microenvironment characterized by poor immune cell infiltration and immune suppression by tumor-associated macrophages (TAMs). TAMs have emerged as potential therapeutic targets to reverse immunosuppression and enhance the effectiveness of immunotherapy. This review focuses on the biological features of TAMs and their relevance as targets for treating EOC, including therapies that modulate TAM recruitment, polarization, survival, and function in the EOC tumor microenvironment for better combinatorial regimens with immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Nanoscience & Nanotechnology
Jiaxing Feng, Ling Xiang, Changlong Fang, Yulu Tan, Yan Li, Ting Gong, Qingsi Wu, Tao Gong, Zhirong Zhang
Summary: THP-PSA NPs exhibit stronger cytotoxicity against 4T1 and M2 macrophages compared with THP-HSA NPs in vitro. In vivo, MDSCs infiltration and immunosuppressive cytokines secretion significantly decrease after effective elimination of TAMs through THP-PSA NPs treatment, accompanied by an increase in immunostimulatory cytokine expression.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Immunology
Alberto Mantovani, Federica Marchesi, Sebastien Jaillon, Cecilia Garlanda, Paola Allavena
Summary: Myeloid cells in tumor tissues, including tumor-associated macrophages and tumor-associated neutrophils, play crucial roles in tumor growth and invasion. In recent years, successful therapeutic approaches have been developed and tested in preclinical cancer models, with some strategies reaching clinical trials.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Meeting Abstract
Oncology
Daniel C. Rabe, Casey Frankenberger, Russell Bainer, Devipriya Sankarasharma, Kiran Chada, Thomas Krausz, Yoav Gilad, Lev Becker, Marsha R. Rosner
Meeting Abstract
Oncology
Ali E. Yesilkanal, Casey Frankenberger, Daniel C. Rabe, Gary L. Johnson, Marsha Rosner
Article
Multidisciplinary Sciences
Russell Bainer, Casey Frankenberger, Daniel Rabe, Gary An, Yoav Gilad, Marsha Rich Rosner
SCIENTIFIC REPORTS
(2016)
Meeting Abstract
Oncology
Daniel C. Rabe, Jiyoung Lee, Felicia Rustandy, Marsha R. Rosner
Article
Multidisciplinary Sciences
Jiyoung Lee, Ali E. Yesilkanal, Joseph P. Wynne, Casey Frankenberger, Juan Liu, Jielin Yan, Mohamad Elbaz, Daniel C. Rabe, Felicia D. Rustandy, Payal Tiwari, Elizabeth A. Grossman, Peter C. Hart, Christie Kang, Sydney M. Sanderson, Jorge Andrade, Daniel K. Nomura, Marcelo G. Bonini, Jason W. Locasale, Marsha Rich Rosner
Article
Multidisciplinary Sciences
Avanish Mishra, Taronish D. Dubash, Jon F. Edd, Michelle K. Jewett, Suhaas G. Garre, Nezihi Murat Karabacak, Daniel C. Rabe, Baris R. Mutlu, John R. Walsh, Ravi Kapur, Shannon L. Stott, Shyamala Maheswaran, Daniel A. Haber, Mehmet Toner
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Shannon N. Tessier, Lauren D. Bookstaver, Cindy Angpraseuth, Cleo J. Stannard, Beatriz Marques, Uyen K. Ho, Alona Muzikansky, Berent Aldikacti, Eduardo Reategui, Daniel C. Rabe, Mehmet Toner, Shannon L. Stott
Summary: Extracellular vesicles (EVs) are potential candidates for biomarker discovery and diagnostics. Cryopreservation of EV-containing samples at -80 degrees C for up to 12 days resulted in a significant decrease in EV concentration and RNA yield in both plasma- and media-derived samples. Direct comparison between fresh and cryopreserved samples without cryoprotectant agents showed significant losses in total RNA, but the addition of DMSO and controlled cooling/warming rates improved RNA yield.
Article
Oncology
Daniel C. Rabe, Nykia D. Walker, Felicia D. Rustandy, Jessica Wallace, Jiyoung Lee, Shannon L. Stott, Marsha Rich Rosner
Summary: TNBC is a subtype of breast cancer lacking ER, PR, and HER2 receptors. Tumors are infiltrated by TAMs promoting tumorigenesis. Study shows how tumors recruit macrophages through EVs, altering macrophage phenotype and driving metastasis. EVs could serve as biomarkers and play a role in modulating tumor immune response.
Correction
Multidisciplinary Sciences
Manish A. Shah, Zev A. Wainberg, Daniel V. T. Catenacci, Howard S. Hochster, James Ford, Pamela Kunz, Fa-Chyi Lee, Howard Kallender, Fabiola Cecchi, Daniel C. Rabe, Harold Keer, Anne-Marie Martin, Yuan Liu, Robert Gagnon, Peter Bonate, Li Liu, Tona Gilmer, Donald P. Bottaro
Correction
Multidisciplinary Sciences
Manish A. Shah, Zev A. Wainberg, Daniel V. T. Catenacci, Howard S. Hochster, James Ford, Pamela Kunz, Fa-Chyi Lee, Howard Kallender, Fabiola Cecchi, Daniel C. Rabe, Harold Keer, Anne-Marie Martin, Yuan Liu, Robert Gagnon, Peter Bonate, Li Liu, Tona Gilmer, Donald P. Bottaro
Article
Multidisciplinary Sciences
Jennifer Cable, Kenneth W. Witwer, Robert J. Coffey, Aleksandar Milosavljevic, Ariana K. von Lersner, Lizandra Jimenez, Ferdinando Pucci, Maureen M. Barr, Niek Dekker, Bahnisikha Barman, Daniel Humphrys, Justin Williams, Michele de Palma, Wei Guo, Nuno Bastos, Andrew F. Hill, Efrat Levy, Michael P. Hantak, Clair Crewe, Elena Aikawa, Alan M. Adamczyk, Tamires M. Zanotto, Matias Ostrowski, Tanina Arab, Daniel C. Rabe, Aadil Sheikh, Danilo Rodrigues da Silva, Jennifer C. Jones, Chioma Okeoma, Thomas Gaborski, Qin Zhang, Olesia Gololobova
Summary: Extracellular vesicles (EVs) are small particles released by cells that carry important biomolecules and can act as messengers to coordinate tissue homeostasis and systemic responses. EVs are of growing interest for their potential as diagnostic biomarkers and drug-delivery vehicles. Researchers gathered at the Keystone symposium to discuss standardized language and methodology, new data on EV biology and clinical utility, and novel technologies for EV isolation and characterization.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Daniel C. Rabe, Uyen K. Ho, Adarsh Choudhury, Jessica C. Wallace, Evelyn G. Luciani, Dasol Lee, Elizabeth A. Flynn, Shannon L. Stott
Summary: This work demonstrates a method of depositing biotin onto the surface of a plastic microfluidic chip using aryl-diazonium, which chemically bonds biotin to the surface and allows for the addition of streptavidin nanoparticles. The nanoparticles increase the chip's surface area and improve the orientation of capture moieties. This method offers faster, cost-effective, and scalable production of devices, including those used for diagnostic testing.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Medicine, Research & Experimental
Rebecca L. Porter, Siyu Sun, Micayla N. Flores, Emily Berzolla, Eunae You, Ildiko E. Phillips, K. C. Neelima, Niyati Desai, Eric C. Tai, Annamaria Szabolcs, Evan R. Lang, Amaya Pankaj, Michael J. Raabe, Vishal Thapar, Katherine H. Xu, Linda T. Nieman, Daniel C. Rabe, David L. Kolin, Elizabeth H. Stover, David Pepin, Shannon L. Stott, Vikram Deshpande, Joyce F. Liu, Alexander Solovyov, Ursula A. Matulonis, Benjamin D. Greenbaum, David T. Ting
Summary: The aberrant expression of viral-like repeat elements is a common characteristic of epithelial cancers and their substantial diversity offers a unique perspective on the cancer transcriptome. In-depth analysis of ovarian cancer cell lines reveals that the expression of the satellite repeat element HSATII is highly associated with epithelial-mesenchymal transition (EMT) and negatively correlated with IFN-response genes, indicating a more aggressive cancer phenotype. Moreover, repeat RNAs are enriched in tumor-derived extracellular vesicles that can modulate the tumor microenvironment. Targeting HSATII with antisense locked nucleic acids stimulates IFN response and induces MHC I expression, suggesting a potential strategy for modulating the repeatome to enhance anti-tumor immune surveillance.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Meeting Abstract
Oncology
M. M. Lee, D. C. Rabe, T. C. Mckee, G. M. Woldemichael, J. R. Vasselli, J. B. McMahon, D. M. De Silva, A. Roy, W. M. Linehan, D. P. Bottaro
EUROPEAN JOURNAL OF CANCER
(2018)
Meeting Abstract
Oncology
Daniel C. Rabe, Casey Frankenberger, Russell Bainer, Devipriya Sankarasharma, Kiran Chada, Thomas Krausz, Yoav Gilad, Lev Becker, Marsha Rich Rosner