Article
Immunology
Shivani Yadav, Parmeswar Dalai, Sharath Gowda, Manish Nivsarkar, Reena Agrawal-Rajput
Summary: Antibiotic treatment with azithromycin (AZM) affects bone marrow-derived macrophage (Mφ) generation and their functions, leading to altered Mφ phenotypes and subsequent effects on bacterial clearance and T-cell responses. AZM increases M2-skewed Mφ generation and promotes an anti-inflammatory phenotype, reducing proinflammatory cytokines and increasing anti-inflammatory cytokines. CSF-1R blockade reverses some of these effects, indicating the involvement of CSF-1R signaling. This study highlights the importance of investigating AZM-induced changes in Mφ generation during intracellular infections.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Editorial Material
Oncology
Won Jin Ho, Elizabeth M. Jaffee
Summary: The study conducted by Zhu and colleagues in 2014 demonstrated that macrophage-specific targeting by blocking CSF1 signaling through CSF1R, in combination with checkpoint immunotherapy, could enhance antitumor immunity in mouse models of pancreatic cancer. This mechanistic leap led to further efforts to translate CSF1/CSF1R-specific and other tumor-associated macrophage modulating therapies into clinical applications.
Article
Pharmacology & Pharmacy
Caigui Xiang, Heng Li, Wei Tang
Summary: CSF-1R, expressed in myeloid cells, regulates the proliferation, differentiation, migration, and activation of immune cells through activation of downstream signaling pathways. Its excessive activation is implicated in inflammatory diseases and has potential therapeutic implications in tumors by depleting and reprogramming tumor-associated macrophages. However, the pathological mechanism of CSF-1R in inflammation remains unclear and its role as a biomarker is controversial.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Caigui Xiang, Chen Fan, Qiukai Lu, Moting Liu, Huimin Lu, Chunlan Feng, Yanwei Wu, Bing Wu, Heng Li, Wei Tang
Summary: Our study demonstrated that CSF-1R expression was increased in HDM-induced experimental asthma and inhibition of CSF-1R significantly affected the disease severity of asthma by suppressing allergic mediators secretion, airway epithelium dysfunction, and inflammatory cells infiltration. Furthermore, CSF-1R inhibitor could notably restrain the polarization and expression of transcriptional factors of alternatively activated macrophages (AAMs) induced by IL-4/IL-13 and reduce the recruitment of CSF1R-dominant macrophages in both acute and chronic allergic airway inflammation models.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jie Yang, Shanshan Li, Zhenyan Li, Lutian Yao, Meijing Liu, Kui-Leung Tong, Qiutong Xu, Bo Yu, Rui Peng, Tao Gui, Wang Tang, Yidi Xu, Jiaxu Chen, Jun He, Kewei Zhao, Xiaogang Wang, Xiaoying Wang, Zhengang Zha, Huan-Tian Zhang
Summary: The enrichment of M1 macrophages and enhanced glycolysis of fibroblast-like synoviocytes (FLSs) play key roles in the pathogenesis of diabetic osteoarthritis (DOA). The yes-associated protein 1 (YAP1)/thioredoxin-interacting protein (TXNIP) signaling axis regulates the glycolysis of FLSs, which fine-tunes the recruitment and infiltration of M1 macrophages. Furthermore, M1 macrophage membrane-camouflaged verteporfin (Vt)-loaded nanoparticles significantly alleviate DOA by suppressing the YAP1/TXNIP signaling-regulated synovial glycolysis and M1 macrophage infiltration.
Review
Immunology
Giovanni Monteleone, Claudia Maresca, Marco Colella, Teresa Pacifico, Daniele Congiu, Edoardo Troncone, Irene Marafini
Summary: This article reviews the current understanding of the involvement of interleukin-34 (IL-34) and its receptor, macrophage colony-stimulating factor-1 receptor (MCSF-1R), in colorectal cancer (CRC). It highlights the role of the IL-34/MCSF-1R axis in controlling tumor-associated macrophages (TAMs) and promoting cancer resistance to chemotherapy and immunotherapy. The findings suggest that targeting IL-34/MCSF-1R could be a potential therapeutic intervention in CRC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maliha Afroj Zinnia, Abul Bashar Mir Md. Khademul Islam
Summary: This study identified potential oral inhibitors from Fenugreek to lower osteoclastogenic bone resorption, with higher binding affinities and bioavailability than current drugs. The compounds were shown to block signaling pathways, resulting in decreased osteoclast survival, proliferation, and differentiation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Multidisciplinary Sciences
Justine Lengrand, Ievgenia Pastushenko, Sebastiaan Vanuytven, Yura Song, David Venet, Rahul M. Sarate, Melanie Bellina, Virginie Moers, Alice Boinet, Alejandro Sifrim, Nicolas Rama, Benjamin Ducarouge, Jens Van Herck, Christine Dubois, Samuel Scozzaro, Sophie Lemaire, Sarah Gieskes, Sophie Bonni, Amandine Collin, Nicolas Braissand, Justine Allard, Egor Zindy, Christine Decaestecker, Christos Sotiriou, Isabelle Salmon, Patrick Mehlen, Thierry Voet, Agnes Bernet, Cedric Blanpain
Summary: Epithelial-to-mesenchymal transition (EMT) plays a crucial role in cancer initiation, progression, metastasis, and resistance to therapy. In this study, the upregulation of netrin-1 in skin squamous cell carcinoma (SCC) was found to induce EMT, and pharmacological inhibition of netrin-1 decreased EMT and enhanced chemotherapy sensitivity. These findings suggest a potential therapeutic strategy for targeting EMT in cancer.
Article
Endocrinology & Metabolism
Asumi Iesato, Stephanie Li, Peter M. Sadow, Mohammadreza Abbasian, Ara Nazarian, Jack Lawler, Carmelo Nucera
Summary: Anaplastic thyroid carcinoma (ATC) is a rapidly fatal cancer, and understanding the genetics and tumor microenvironment is crucial for effective management. Pericytes in the microenvironment play a key role in ATC, and the effectiveness of lenvatinib in ATC is not well understood. This study found that ATC samples have elevated levels of pericytes and lenvatinib showed inhibitory effects in the presence of pericytes.
Article
Oncology
Lee Huang, Yougang Zhai, Jennifer La, Jason W. Lui, Stephen P. G. Moore, Elizabeth C. Little, Sixia Xiao, Adil J. Haresi, Candice Brem, Jag Bhawan, Deborah Lang
Summary: The study identifies multiple overlapping functions of the ETS family promoting melanoma and demonstrates the potential therapeutic impact of targeting these factors with the small molecule YK-4-279. By inhibiting multiple ETS family members, YK-4-279 shows promising antitumor effects in melanoma.
Article
Cell Biology
Elisabetta Vergani, Giovanni L. Beretta, Mariachiara Aloisi, Matteo Costantino, Cristina Corno, Simona Frigerio, Stella Tinelli, Matteo Dugo, Felice Maria Accattatis, Agnese Granata, Lorenzo Arnaboldi, Monica Rodolfo, Paola Perego, Laura Gatti
Summary: The study investigated the impact of lipid metabolism on melanoma sensitivity to BRAF inhibitors, revealing that targeting lipid metabolism pathways in resistant cells reduces cell growth, increases drug sensitivity, and induces the expression of enzymes involved in fatty acid and cholesterol metabolism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Salvatore Ulisse, Enke Baldini, Daniele Pironi, Federica Gagliardi, Domenico Tripodi, Augusto Lauro, Sabino Carbotta, Danilo Tarroni, Matteo D'Armiento, Aldo Morrone, Flavio Forte, Flaminia Frattaroli, Severino Persechino, Teresa Odorisio, Vito D'Andrea, Eleonora Lori, Salvatore Sorrenti
Summary: There is evidence suggesting a relationship between thyroid diseases and melanoma, with hypothyroidism potentially promoting melanoma spread and thyroid hormones playing a protective role. Other hormonal factors in the hypothalamic-pituitary-thyroid (HPT) axis may also affect melanoma cell behavior. Further research is needed to understand the precise action of HPT hormones on melanoma cells, which could lead to improved and personalized clinical management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jingtai Zhi, Linfei Hu, Yuyang Qian, Ning Kang, Xinwei Yun, Xin Wang, Xianhui Ruan, Dongmei Huang, Weiwei Yang, Xiangrui Meng, Tianze Zhu, Wei Wang, Xiangqian Zheng
Summary: This study reveals the crucial role of Aurora-A in regulating energy supply in thyroid cancer cells, and highlights the potential of combining Alisertib with Sorafenib for treating advanced thyroid carcinoma.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Mi-Hyeon You, Min Ji Jeon, Seong ryeong Kim, Woo Kyung Lee, Sheue-yann Cheng, Goo Jang, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Won Gu Kim
Summary: The study revealed that MFN2 may act as a tumor suppressor in thyroid cancer, affecting cell migration and invasion by modulating epithelial to mesenchymal transition.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Chanmi Jeong, Jeongdong Kim, Ik-Hwan Han, Soyoung Kim, Ilseob Choi, Hongsung Kim, Jin-Hyun Jeong, Hyunsu Bae
Summary: This study evaluates the therapeutic effects of M-DM1 on melanoma. The results show that M-DM1 can specifically reduce M2-like tumor-associated macrophages, inhibit tumor growth and invasion, and improve survival rates. Additionally, M-DM1 enhances the infiltration of CD8+ cytotoxic T cells and natural killer cells in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Allen W. Zhang, Sejal Morjaria, Anna Kaltsas, Tobias M. Hohl, Rekha Parameswaran, Dhruvkumar Patel, Wei Zhou, Jacqueline Predmore, Rocio Perez-Johnston, Justin Jee, Anthony F. Daniyan, Miguel-Angel Perales, Ying Taur
Summary: The use of G-CSF in cancer patients with COVID-19 may increase the risk of hospitalization, respiratory failure, and death. Careful consideration should be given to the potential risks and benefits of G-CSF treatment in neutropenic cancer patients with COVID-19.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Elizabeth Robilotti, Karissa Whiting, Anabella Lucca, Chester Poon, Rebecca Guest, Tracy McMillen, Krupa Jani, Alexander Solovyov, Suzanne Kelson, Kevin Browne, Scott Freeswick, Tobias M. Hohl, Deborah Korenstein, Denis Ruchnewitz, Michael Lassig, Marta Luksza, Benjamin Greenbaum, Venkatraman E. Seshan, N. Esther Babady, Mini Kamboj
Summary: A study of over 13000 healthcare personnel (HCP) showed that messenger RNA (mRNA) vaccine effectiveness (VE) against coronavirus disease 2019 (COVID-19) was 94% through initial 5 months of follow-up, with moderate VE reduction to 75% during subsequent Delta-dominant period. No hospitalizations occurred among vaccinated HCP throughout the study period.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Genetics & Heredity
Caoimhe E. O'Brien, Bing Zhai, Mihaela Ola, Sean A. Bergin, Eoin O. Cinneide, Isla O'Connor, Thierry Rolling, Edwin Miranda, N. Esther Babady, Tobias M. Hohl, Geraldine Butler
Summary: The Candida metapsilosis AC isolate, originating from a separate hybridization event, is different from the AB isolates, as it has not undergone introgression at the mating type-like locus and is in the early stages of genome stabilization.
G3-GENES GENOMES GENETICS
(2022)
Article
Medicine, Research & Experimental
Thierry Rolling, Bing Zhai, John Frame, Tobias M. Hohl, Ying Taur
Summary: Identification and analysis of fungal communities commonly rely on ITS-based amplicon sequencing. In this study, a customized DADA2-based pipeline was used to achieve high-resolution inference of fungal constituents. Quality filtering, sequencing bias, and database selection were identified as key variables determining the accuracy of sample inference. By fine-tuning the filtering process and introducing a wobble nucleotide, the representation of fungal communities was improved. Additionally, a BLAST-based algorithm showed higher reliability in species-level taxonomic annotation compared with the naive Bayesian classifier implemented in DADA2.
Article
Oncology
Roni Shouval, Nicholas R. Waters, Antonio L. C. Gomes, Corrado Zuanelli Brambilla, Teng Fei, Sean M. Devlin, Chi L. Nguyen, Kate A. Markey, Anqi Dai, John B. Slingerland, Annelie G. Clurman, Emily Fontana, Luigi A. Amoretti, Roberta J. Wright, Tobias M. Hohl, Ying Taur, Anthony D. Sung, Daniela Weber, Daigo Hashimoto, Takanori Teshima, Nelson J. Chao, Ernst Holler, Michael Scordo, Sergio A. Giralt, Miguel-Angel Perales, Jonathan U. Peled, Marcel R. M. van den Brink
Summary: We investigated the relationship between gut microbiota disruption and preparative conditioning regimens in allogeneic hematopoietic cell transplantation (allo-HCT) recipients. Our findings suggest that high-intensity conditioning regimens are associated with the most severe microbiota injury, while non-myeloablative regimens are associated with mild injury. Pretransplant microbial compositions are best preserved with certain conditioning regimens, while others result in loss of commensal bacteria and expansion of Enterococcus.
CLINICAL CANCER RESEARCH
(2023)
Article
Microbiology
Sean A. Bergin, Fang Zhao, Adam P. Ryan, Carolin A. Muller, Conrad A. Nieduszynski, Bing Zhai, Thierry Rolling, Tobias M. Hohl, Florent Morio, Jillian Scully, Kenneth H. Wolfe, Geraldine Butler
Summary: We analyzed the genomes of 170 C. parapsilosis isolates and identified multiple copy number variations (CNVs). We found that the increased copy number of the RTA3 gene is associated with resistance to the drug miltefosine. Additionally, we discovered that mutations in flippase genes can also contribute to resistance.
Article
Oncology
Laura Boucai, Mahesh Saqcena, Fengshen Kuo, Ravinder K. Grewal, Nicholas Socci, Jeffrey A. Knauf, Gnana P. Krishnamoorthy, Mabel Ryder, Alan L. Ho, Ronald A. Ghossein, Luc G. T. Morris, Venkatraman Seshan, James A. Fagin
Summary: The determinants of response or resistance to radio-iodine (RAI) are unknown. The study aimed to identify genomic and transcriptomic factors associated with structural responses to RAI treatment of metastatic thyroid cancer. It was found that high MAPK pathway output was associated with RAI refractoriness. ER tumors have a lower MAPK output and higher TDS than NR, whereas NR have a high frequency of BRAFV600E and 1q-gain. Molecular profiling of thyroid cancers may help predict response to RAI therapy.
CLINICAL CANCER RESEARCH
(2023)
Review
Endocrinology & Metabolism
Matti L. Gild, Roderick J. Clifton-Bligh, Lori J. Wirth, Bruce G. Robinson
Summary: A personalized approach to MTC management has overcome challenges through advancements in diagnostic and treatment modalities, including RET testing and novel imaging techniques. Systemic therapy for persistent and metastatic disease has greatly improved with the use of targeted kinase inhibitors such as selpercatinib and pralsetinib. This article discusses the changing paradigms in MTC patient care and the evolving management strategies for this heterogeneous malignancy.
Review
Immunology
Lena J. Heung, Darin L. Wiesner, Keyi Wang, Amariliz Rivera, Tobias M. Hohl
Summary: The respiratory tree plays a crucial role in maintaining sterilizing immunity against fungal pathogens. Fungal pneumonia usually occurs in individuals with compromised immune systems, such as HIV/AIDS patients, organ transplant recipients, and those undergoing corticosteroids treatment. Additionally, respiratory viruses and medical therapies used to treat viral infections can impair the lung's immune defense against fungi. Understanding lung-specific antifungal immunity has the potential to improve diagnostic, preventive, therapeutic, and vaccine strategies against fungal diseases of the lung.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Matti L. Gild, Martyn Bullock, Venessa Tsang, Roderick J. Clifton-Bligh, Bruce G. Robinson, Lori J. Wirth
Summary: This study identified actionable targets in thyroid cancer, including mutations in BRAF(V600E), N/H/K RAS, and oncogenic kinase fusions involving NTRK, RET, ALK, and ROS1. However, acquired resistance may develop, necessitating the exploration of new therapeutic strategies.
Article
Immunology
Mariano A. Aufiero, Neta Shlezinger, Mergim Gjonbalaj, Kathleen A. M. Mills, Andrea Ballabio, Tobias M. Hohl
Summary: Research has shown that myeloid phagocytes activate TFEB and TFE3 in response to Aspergillus fumigatus infection, which is crucial for lung immunity. However, genetic loss of TFEB and TFE3 does not significantly impact fungal control and host survival.
INFECTION AND IMMUNITY
(2023)
Article
Microbiology
Matthew R. James, Mariano A. Aufiero, Elisa M. Vesely, Sourabh Dhingra, Ko-Wei Liu, Tobias M. Hohl, Robert A. Cramer
Summary: This study identifies an important aspect of fungal biology in A. fumigatus that impacts susceptibility to leukocyte killing.
Article
Respiratory System
Guang-Shing Cheng, Kristina Crothers, Stefano Aliberti, Anne Bergeron, Michael Boeckh, Jason W. Chien, Catia Cilloniz, Keira Cohen, Nathan Dean, Charles S. Dela Cruz, Robert P. Dickson, Alexander L. Greninger, Chadi A. Hage, Tobias M. Hohl, Steven M. Holland, Barbara E. Jones, Joseph Keane, Mark Metersky, Rachel Miller, Anne Puel, Julio Ramirez, Marcos Restrepo, Ajay Sheshadri, Bashar Staitieh, Jeffrey Tarrand, Kevin L. Winthrop, Richard G. Wunderink, Scott E. Evans
Summary: Pneumonia poses a clinical burden on immunocompromised individuals, who are often excluded from clinical guidelines and trials. The lack of a widely accepted definition for immunocompromised host pneumonia hampers consistent care and research. To address this, the American Thoracic Society convened a workshop to define immunocompromised host pneumonia and its diagnostic criteria.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Review
Immunology
Michail S. S. Lionakis, Rebecca A. A. Drummond, Tobias M. M. Hohl
Summary: Pathogenic fungi have become major causes of infectious morbidity and mortality in patients with immunodeficiency conditions, and the spread of multidrug-resistant Candida auris has raised global public health concerns. Advances in understanding the cellular and molecular determinants of antifungal immunity provide potential strategies for risk stratification, prognosis, prophylaxis, and therapy against life-threatening fungal infections.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Deepika Awasthi, Sahil Chopra, Byuri A. Cho, Alexander Emmanuelli, Tito A. Sandoval, Sung-Min Hwang, Chang-Suk Chae, Camilla Salvagno, Chen Tan, Liliana Vasquez-Urbina, Jose J. Fernandez Rodriguez, Sara F. Santagostino, Takao Iwawaki, E. Alfonso Romero-Sandoval, Mariano Sanchez Crespo, Diana K. Morales, Iliyan D. Iliev, Tobias M. Hohl, Juan R. Cubillos-Ruiz
Summary: Infection with Candida albicans triggers hyperactivation of IRE1 alpha, leading to kidney immunopathology. Activation of MyD88 and dectin-1 by C. albicans causes ROS generation, ER stress, and overexpression of inflammatory mediators through IRE1 alpha. Inhibiting IRE1 alpha can mitigate inflammation and improve survival in systemic C. albicans infection.
JOURNAL OF CLINICAL INVESTIGATION
(2023)