Article
Cell Biology
Guang-Ping Lang, Can Li, Ying-Ying Han
Summary: Pretreatment with rutin can promote the phenotypic switch of microglia from M1 to M2 by inhibiting the Toll-like receptor 4/nuclear factor-κB signaling pathway to alleviate lipopolysaccharide-induced neuroinflammation.
NEURAL REGENERATION RESEARCH
(2021)
Article
Chemistry, Medicinal
Weiwei Guo, Xiujun Liu, Junting Guo, Ruijuan Gao, Xiaodong Xiang, Xiqiang An, Liping Bai
Summary: Brassica rapa polysaccharides (BRP) have been shown to have anti-tumor effects by regulating macrophage polarization, promoting M1 markers expression and inhibiting M2 markers expression.
PHYTOTHERAPY RESEARCH
(2022)
Review
Medicine, Research & Experimental
Zuzana Strizova, Iva Benesova, Robin Bartolini, Rene Novysedlak, Eva Cecrdlova, Lily Koumbas Foley, Ilja Striz
Summary: Macrophages are a heterogeneous cell population with various roles in defense mechanisms and tissue homeostasis. They can adopt different activation states depending on the microenvironment and natural signals they receive.
Article
Oncology
Franziska Brauneck, Brit Fischer, Marius Witt, Jana Muschhammer, Jennyfer Oelrich, Pedro Henrique da Costa Avelar, Sophia Tsoka, Lars Bullinger, Elisa Seubert, Daniel J. Smit, Carsten Bokemeyer, Christin Ackermann, Jasmin Wellbrock, Friedrich Haag, Walter Fiedler
Summary: This study characterized macrophages in patients with acute myeloid leukemia, finding that immunosuppressive TIGIT(+) M2 LAMs can be redirected into an efficient effector population, which may have direct clinical relevance in the near future.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Anatomy & Morphology
Hengfang Zhang, Shuang Zhang, Xuan Dang, Lexun Lin, Liping Ren, Rong Song
Summary: Macrophages play a crucial role in the development of periodontitis and their phenotype is influenced by GPNMB protein. Overexpression of GPNMB in macrophages was found to enhance the secretion of anti-inflammatory factors and inhibit the secretion of pro-inflammatory factors.
Review
Biochemistry & Molecular Biology
Luis Alberto Videla, Rodrigo Valenzuela, Andrea Del Campo, Jessica Zuniga-Hernandez
Summary: The complex relationship between dietary factors, inflammation, and macrophage polarization plays a crucial role in the development of chronic liver diseases. Omega-3 fatty acids and their specialized pro-resolving mediators (SPMs) have shown the potential to modulate inflammation and promote a shift towards an anti-inflammatory macrophage phenotype. These substances have demonstrated hepatoprotective effects by reducing oxidative stress and inhibiting key inflammatory pathways, promoting tissue repair, and attenuating liver injury in various chronic liver diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Roxana-Olimpia Gheorghe, Andreea Violeta Grosu, Melania Magercu, Mihail-Sebastian Ghenghea, Cristina Elena Zbarcea, Alexandra Tanase, Simona Negres, Alexandru Filippi, Gabriela Chiritoiu, Mihaela Gherghiceanu, Sorina Dinescu, Gisela Gaina, Damir Sapunar, Violeta Ristoiu
Summary: In the early stages after traumatic nerve injury, resident macrophages in the dorsal root ganglia play a crucial role in the development of neuropathic pain. By interacting with the cytoskeleton, these macrophages can be transformed into an anti-inflammatory phenotype, leading to a reduction in neuropathic pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Jiuyang Liu, Xiafei Geng, Jinxuan Hou, Gaosong Wu
Summary: This article examines the critical roles of M1 and M2 macrophages in tumor progression, with M1 possessing anti-tumor properties and M2 promoting tumor growth and metastasis.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Hong Zhen, Hongbo Hu, Guojie Rong, Xiuxiu Huang, Chang Tan, Xinyuan Yu
Summary: Administration of vitamin A or vitamin D can alleviate BPD-linked pulmonary injury induced by LPS and have a significant impact on macrophage polarization.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Antong Wu, Janak Lal. Pathak, Xingyang Li, Wei Cao, Wenchao Zhong, Mingjing Zhu, Qiuyu Wu, Wanyi Chen, Qiao Han, Siqing Jiang, Yuzhuo Hei, Ziyi Zhang, Gang Wu, Qingbin Zhang
Summary: In this study, the efficacy of human salivary peptide histatin-1 (Hst1) in attenuating bone and cartilage damage in osteoarthritis (OA) was investigated. Hst1 was found to significantly attenuate cartilage and bone deconstruction as well as macrophage infiltration. It also triggered M1-to-M2 macrophage phenotype switching and restored the metabolic activity, migration, and chondrogenic differentiation of chondrogenic cells.
Article
Dermatology
Wael M. Seoudy, Sara M. Mohy El Dien, Talal A. Abdel Reheem, Mona M. Elfangary, Moatasem A. Erfan
Summary: This study suggests that M1 and M2 macrophages play important roles in the pathogenesis of keloid formation. Keloid formation might be a result of an abnormal response to tissue injury with excessive entry of inflammatory cells, including macrophages, into the wound, and the incidence of keloid might be related to a decrease in M1 and an increase in M2.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Sathuwarman Raveenthiraraj, Griselda Awanis, Marcello Chieppa, Amy E. O'Connell, Anastasia Sobolewski
Summary: This study demonstrates the different effects of homeostatic and inflammatory macrophages on the colonic epithelium. Inflammatory macrophages reduce the numbers of goblet and tuft cells and increase the numbers of stem cells in the crypt, while homeostatic macrophages promote crypt cell proliferation through physical contact. The findings highlight the importance of understanding cellular interactions and immune cell subtypes in crypt cell biology during inflammation.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Oncology
Weilin Sun, Xi Wang, Daohan Wang, Li Lu, Hai Lin, Zhaoxiong Zhang, Yangpu Jia, Xinyang Nie, Tong Liu, Weihua Fu
Summary: The CCL2-ZC3H12A-TRAF6/3 signaling axis plays a crucial role in trastuzumab resistance in HER2-positive gastric cancer. The CD40 xHER2 bsAb shows great antitumor efficacy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Engineering, Biomedical
M. Bessa-Goncalves, C. Ribeiro-Machado, M. Costa, C. C. Ribeiro, J. N. Barbosa, M. A. Barbosa, S. G. Santos
Summary: This study demonstrated that the incorporation of 10mM of magnesium sulfate improved the mechanical properties of the fibrinogen scaffold and promoted macrophage polarization to M2 phenotype. In vivo experiments showed that FgMg10 scaffolds reduced inflammatory mediators and increased M2 macrophage polarization.
ACTA BIOMATERIALIA
(2023)
Article
Biotechnology & Applied Microbiology
Benxin Gong, Ying Zheng, Jiahua Li, Huafeng Lei, Kexin Liu, Jingyun Tang, Yanrong Peng
Summary: This study found that luteolin promotes M2 macrophage polarization and inhibits M1 macrophage polarization, while glycyrrhizic acid does not have these effects. Furthermore, it was discovered that luteolin achieves this regulation by upregulating the expression of hsa_circ_0001326.
Article
Immunology
Diyuan Xue, Benjamin Moon, Jing Liao, Jingya Guo, Zhuangzhi Zou, Yanfei Han, Shuaishuai Cao, Yang Wang, Yang-Xin Fu, Hua Peng
Summary: A tumor-conditional IL-12, pro-IL-12, was developed to selectively activate TILs and control tumor growth with reduced toxicity. Pro-IL-12 improved the efficacy of immune checkpoint blockade and targeted therapy when used in combination.
SCIENCE IMMUNOLOGY
(2022)
Article
Oncology
Ming Wang, Zhongyu Qin, Jiajia Wan, Yan Yan, Xixi Duan, Xiaohan Yao, Ziming Jiang, Wenqing Li, Zhihai Qin
Summary: This study found that tumor-derived exosomes can induce the formation of pre-metastatic niche in the lung by promoting the differentiation of regulatory T cells. This is achieved through the activation of the specific receptor CCR8 by secreted CCL1, resulting in the establishment of an immunologically tolerant microenvironment.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Oncology
Hong Cao, Chen Ni, Le Han, Ruoqi Wang, Rosel Blasig, Reiner Haseloff, Yue Qin, Jie Lan, Xiaohan Lou, Pan Ma, Xiaohan Yao, Linlin Wang, Fei Wang, Linyu Zhu, Ningjing Lei, Ingolf E. Blasig, Zhihai Qin
Summary: This study found that the absence of tight junction protein Claudin-12 (Cldn12) inhibited the growth of transplanted tumors and reduced the accumulation of myeloid-derived suppressor cells (MDSCs) within tumors, resulting in increased anti-tumor immune responses. The study also revealed that expression of Cldn12 on the cell surface of both MDSCs and endothelial cells (EC) is necessary for MDSCs to cross tumor vascular ECs. Therefore, Cldn12 shows promise as a target for restoring anti-tumor response by interfering with MDSCs transendothelial migration.
Article
Multidisciplinary Sciences
Yunjia Zhang, Boxun Li, Sergio Cananzi, Chuanhui Han, Lei-Lei Wang, Yuhua Zou, Yang-Xin Fu, Gary C. Hon, Chun-Li Zhang
Summary: The study reveals that the transcription factor DLX2 can unlock the multipotentiality of adult astrocytes, allowing them to rapidly become neural progenitor cells and differentiate into neurons, astrocytes, and oligodendrocytes. Single-cell transcriptomics and pseudotime trajectories confirm the neural stem cell-like behavior of reprogrammed astrocytes. This discovery provides insights into potential neural regeneration strategies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Jiao Shen, Zhuangzhi Zou, Jingya Guo, Yueqi Cai, Diyuan Xue, Yong Liang, Wenyan Wang, Hua Peng, Yang-Xin Fu
Summary: The engineered αPD-1-IL-15-R fusion protein successfully redirects IL-15 to PD-1(+)CD8(+)T cells, resulting in effective tumor control and reduced toxicity.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Sirui Li, Bhalchandra Mirlekar, Brandon M. Johnson, W. June Brickey, John A. Wrobel, Na Yang, Dingka Song, Sarah Entwistle, Xianming Tan, Meng Deng, Ya Cui, Wei Li, Benjamin G. Vincent, Michael Gale, Yuliya Pylayeva-Gupta, Jenny P. -Y. Ting
Summary: An immunosuppressive tumor microenvironment poses a major obstacle in controlling pancreatic and other solid cancers. Activation of the STING-IL-35 axis in regulatory B cells can expand their activity and overcome tumor immunosuppression. However, this inhibition also attenuates the anti-tumor response of NK cells.
Article
Multidisciplinary Sciences
Yuankun Zhang, Qingxiao Song, Kaniel Cassady, Michael Lee, Haidong Tang, Moqian Zheng, Bixin Wang, Dustin E. Schones, Yang-Xin Fu, Arthur D. Riggs, Paul J. Martin, Ru Feng, Defu Zeng
Summary: Previous assumptions about PD-L1/CD80 interactions being trans have been challenged by recent reports, which suggest that these interactions are actually cis. Blocking PD-L1/CD80 interactions on antigen-presenting cells has been found to reduce antitumor immunity, while blocking both cis and trans interactions or just the trans interactions can enhance antitumor immunity by increasing IFN-γ-producing CD8+ T cells and IFN-γ-dependent NOS2-expressing tumor-associated macrophages. Overall, blocking PD-L1/CD80 interactions in vivo has a net positive effect on CD8+ T cell-mediated antitumor immunity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Multidisciplinary
Yongjuan Li, Ningjing Lei, Xiaohan Yao, Yu Zhang, Ya Dong, Jinmeng Yi, Xinyan Li, Wenjing Deng, Guangjun Nie, Zhihai Qin
Summary: A polyvalent ferroptosis agonist, hPPAA18C6, is developed to stimulate ferroptosis by releasing endogenous iron and depleting glutathione in hypoxia. In addition, hPPAA18C6 acts as an immune adjuvant, facilitating dendritic cells maturation and CD8(+) T-cell activation. The combination of hPPAA18C6 and Ce6 leads to combined therapeutic outcomes in primary, distant, and metastatic tumors.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Wenqing Li, Zihao Wang, Ziming Jiang, Yan Yan, Xiaohan Yao, Zhenzhen Pan, Lin Chen, Fei Wang, Ming Wang, Zhihai Qin
Summary: The study found that miR-3960 levels in bladder cancer tissue were positively correlated with patient survival time. miR-3960 inhibited bladder cancer growth and promoted drug-induced apoptosis by suppressing DEXI expression. These findings suggest that miR-3960 could be a potential therapeutic strategy against bladder cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Yong Liang, Yang-Xin Fu
Article
Chemistry, Medicinal
Jing Ma, Xu Chen, Rui Xue, Fei Wang, Jun Dong, Ning Tao, Zhihai Qin
Summary: This study screened several natural compounds for their inhibitory effects on cytokine storms and found that cinnamaldehyde can effectively inhibit the production of cytokine storms and restore the number of T cells.
PHYTOTHERAPY RESEARCH
(2023)
Letter
Biochemistry & Molecular Biology
Xue Wang, Longchao Liu, Tao Yue, Zhichen Sun, Joonbeom Bae, Kuo-Fu Tseng, Anli Zhang, Jian Qiao, Yang-Xin Fu
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Cell Biology
Bhalchandra Mirlekar, Yan Wang, Sirui Li, Mi Zhou, Sarah Entwistle, Tristan De Buysscher, Ashley Morrison, Gabriela Herrera, Cameron Harris, Benjamin G. Vincent, Jenny P. -Y. Ting, Naim Rashid, William Y. Kim, Jen Jen Yeh, Yuliya Pylayeva-Gupta
Summary: The dysregulation of B cells in patients and tumor-bearing mice often leads to the failure of anti-tumor immune responses. By targeting the signaling network in B cells, the differentiation of B cells into anti-tumor plasma cells can be restored, resulting in increased accumulation of effector T cells and plasma cells in tumors and making pancreatic tumors sensitive to immunotherapy.
CELL REPORTS MEDICINE
(2022)
Article
Oncology
Longchao Liu, Jiahui Chen, Hongyi Zhang, Jianfeng Ye, Casey Moore, Changzheng Lu, Yan Fang, Yang-Xin Fu, Bo Li
Summary: Tumor-specific T cells generated by neoantigen vaccines can synergize with immune checkpoint blockade to effectively control tumors. This unique population of T cells is associated with better survival rates in humans.
Article
Medicine, Research & Experimental
Zhenhua Ren, Anli Zhang, Zhichen Sun, Yong Liang, Jianfeng Ye, Jian Qiao, Bo Li, Yang-Xin Fu
Summary: The study shows that delivering IL-2 to PD-1(+)CD8(+) TILs can enhance the efficacy of anti-PD-1 therapy and reduce toxicity for better tumor control. PD-1-laIL-2 can effectively expand dysfunctional and tumor-specific CD8(+) T cells, with a particular positive effect on PD-1(+)TIM3(+) TILs.
JOURNAL OF CLINICAL INVESTIGATION
(2022)