Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms and strategies

Subcellular regulation of glucose metabolism through multienzyme glucosome assemblies by EGF-ERK1/2 signaling pathways

(2022) Miji Jeon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PRMT5 Inhibition Promotes PD-L1 Expression and Immuno-Resistance in Lung Cancer

(2022) Rui Hu et al.   Frontiers in Immunology

Platycodin D regulates high glucose-induced ferroptosis of HK-2 cells through glutathione peroxidase 4 (GPX4)

(2022) Jinzhong Huang et al.   Bioengineered

Galectin-1 activates carbonic anhydrase IX and modulates glioma metabolism

(2022) Maheedhara R. Guda et al.   Cell Death & Disease

Characterization of Fatty Acid Metabolism-Related Genes Landscape for Predicting Prognosis and Aiding Immunotherapy in Glioma Patients

(2022) Feng Jiang et al.   Frontiers in Immunology

L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression

(2022) Jing Huang et al.   Journal for ImmunoTherapy of Cancer

Glutamine deprivation impairs function of infiltrating CD8+ T cells in hepatocellular carcinoma by inducing mitochondrial damage and apoptosis

(2022) Wei Wang et al.   World Journal of Gastrointestinal Oncology

Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα

(2022) Dong Guo et al.   Cell Metabolism

Regulation of PD-L1 through direct binding of cholesterol to CRAC motifs

(2022) Qian Wang et al.   Science Advances

Phospholipase D and cancer metastasis: A focus on exosomes

(2022) Alexander Wolf et al.   Advances in Biological Regulation

ARID1A loss induces polymorphonuclear myeloid-derived suppressor cell chemotaxis and promotes prostate cancer progression

(2022) Ni Li et al.   Nature Communications

Glucose metabolism involved in PD-L1-mediated immune escape in the malignant kidney tumour microenvironment

(2021) Yongbo Yu et al.   Cell Death Discovery

CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours

(2021) Roberta Zappasodi et al.   NATURE

Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses

(2021) Ke Xu et al.   IMMUNITY

Inhibition of xCT suppresses the efficacy of anti-PD-1/L1 melanoma treatment through exosomal PD-L1-induced macrophage M2 polarization

(2021) Nian Liu et al.   MOLECULAR THERAPY

Post-translational regulations of PD-L1 and PD-1: Mechanisms and opportunities for combined immunotherapy

(2021) Xiaoming Dai et al.   SEMINARS IN CANCER BIOLOGY

Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan

(2021) Patrick C. Bradshaw   Antioxidants

Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer

(2021) Hao Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia

(2021) Daniela Di Marcantonio et al.   MOLECULAR CELL

STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation

(2021) Takashi Nakamura et al.   Journal for ImmunoTherapy of Cancer

AMPK promotes antitumor immunity by downregulating PD-1 in regulatory T cells via the HMGCR/p38 signaling pathway

(2021) Ram Hari Pokhrel et al.   Molecular Cancer

The foundations of immune checkpoint blockade and the ipilimumab approval decennial

(2021) Alan J. Korman et al.   NATURE REVIEWS DRUG DISCOVERY

Tumor-associated macrophages promote PD-L1 expression in tumor cells by regulating PKM2 nuclear translocation in pancreatic ductal adenocarcinoma

(2021) Qing Xia et al.   ONCOGENE

Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis

(2021) Shuyu Yu et al.   ONCOGENE

Fueling T-cell Antitumor Immunity: Amino Acid Metabolism Revisited

(2021) Chenfeng Han et al.   Cancer Immunology Research

A Combination of Glutaminase Inhibitor 968 and PD-L1 Blockade Boosts the Immune Response against Ovarian Cancer

(2021) Jing-Jing Wang et al.   Biomolecules

Comprehensive analysis of the association between tumor glycolysis and immune/inflammation function in breast cancer

(2020) Wenhui Li et al.   Journal of Translational Medicine

Insulin–PI3K signalling: an evolutionarily insulated metabolic driver of cancer

(2020) Benjamin D. Hopkins et al.   Nature Reviews Endocrinology

ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis

(2020) Hong Liu et al.   CANCER CELL

Acquired Resistance to Immune Checkpoint Inhibitors

(2020) Adam J. Schoenfeld et al.   CANCER CELL

Leptin: Less Is More

(2020) Shangang Zhao et al.   DIABETES

The IKKβ-USP30-ACLY Axis Controls Lipogenesis and Tumorigenesis

(2020) Li Gu et al.   HEPATOLOGY

Deficiency of histone methyltransferase SETD2 in liver leads to abnormal lipid metabolism and hepatocarcinoma

(2020) Xue‐Jing Li et al.   HEPATOLOGY

LKB1 inhibits intrahepatic cholangiocarcinoma by repressing the transcriptional activity of the immune checkpoint PD-L1

(2020) Zhuo Liu et al.   LIFE SCIENCES

Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

(2020) Yang Gao et al.   NATURE CELL BIOLOGY

NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion

(2020) Hongwei Lv et al.   Cell Metabolism

5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology

(2020) Massimo E. Maffei   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lipid metabolism and cancer

(2020) Xueli Bian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade

(2020) Gladys Ferrere et al.   JCI Insight

Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice

(2020) Padma Kadiyala et al.   JOURNAL OF CLINICAL INVESTIGATION

Blockade of Lactate Dehydrogenase-A (LDH-A) Improves Efficacy of Anti-Programmed Cell Death-1 (PD-1) Therapy in Melanoma

(2019) Saeed Daneshmandi et al.   Cancers

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

(2019) Felipe J. Núñez et al.   Science Translational Medicine

An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade

(2019) Lynda Vuong et al.   CANCER RESEARCH

Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours

(2019) Han Yao et al.   Nature Biomedical Engineering

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

(2019) Xingzhe Ma et al.   Cell Metabolism

Platycodin D triggers the extracellular release of programed death Ligand-1 in lung cancer cells

(2019) Mu-Yang Huang et al.   FOOD AND CHEMICAL TOXICOLOGY

MAPK pathway activity plays a key role in PD‐L1 expression of lung adenocarcinoma cells

(2019) Thijs S Stutvoet et al.   JOURNAL OF PATHOLOGY

Cystine–glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity

(2019) Michael D. Arensman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

(2019) David W. Vredevoogd et al.   CELL

Epidermal Growth Factor Receptor (EGFR) Pathway, Yes-Associated Protein (YAP) and the Regulation of Programmed Death-Ligand 1 (PD-L1) in Non-Small Cell Lung Cancer (NSCLC)

(2019) Ping-Chih Hsu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immune checkpoint inhibitors of PD-L1 as cancer therapeutics

(2019) Akintunde Akinleye et al.   Journal of Hematology & Oncology

ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer

(2019) Shigeru Hashimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP-citrate lyase (ACLY) in lipid metabolism and atherosclerosis: An updated review

(2019) Xiaojun Feng et al.   PROGRESS IN LIPID RESEARCH

PD-L1 regulation by SDH5 via β-catenin/ZEB1 signaling

(2019) Zhan Tuo et al.   OncoImmunology

Prim-O-glucosylcimifugin enhances the antitumour effect of PD-1 inhibition by targeting myeloid-derived suppressor cells

(2019) Wanfeng Gao et al.   Journal for ImmunoTherapy of Cancer

Galectin-1–driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance

(2019) Dhanya K. Nambiar et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of hypoxia in cancer therapy by regulating the tumor microenvironment

(2019) Xinming Jing et al.   Molecular Cancer

Glutamine Deprivation Induces PD-L1 Expression via Activation of EGFR/ERK/c-Jun Signaling in Renal Cancer

(2019) Guofeng Ma et al.   MOLECULAR CANCER RESEARCH

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

Adenosine 2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer

(2019) Lawrence Fong et al.   Cancer Discovery

Tumor-Repopulating Cells Induce PD-1 Expression in CD8 + T Cells by Transferring Kynurenine and AhR Activation

(2018) Yuying Liu et al.   CANCER CELL

Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation

(2018) Rachel J. Perry et al.   CELL

IFN-γ-mediated inhibition of lung cancer correlates with PD-L1 expression and is regulated by PI3K-AKT signaling

(2018) Yi Gao et al.   INTERNATIONAL JOURNAL OF CANCER

The IDH1 Mutation-Induced Oncometabolite, 2-Hydroxyglutarate, May Affect DNA Methylation and Expression of PD-L1 in Gliomas

(2018) Luyan Mu et al.   Frontiers in Molecular Neuroscience

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

(2018) Jong-Ho Cha et al.   MOLECULAR CELL

PPAR-induced fatty acid oxidation in T cells increases the number of tumor-reactive CD8+ T cells and facilitates anti-PD-1 therapy

(2018) Partha S. Chowdhury et al.   Cancer Immunology Research

A2AR Antagonism with CPI-444 Induces Antitumor Responses and Augments Efficacy to Anti–PD-(L)1 and Anti–CTLA-4 in Preclinical Models

(2018) Stephen B. Willingham et al.   Cancer Immunology Research

Palmitoylation stabilizes PD-L1 to promote breast tumor growth

(2018) Yi Yang et al.   CELL RESEARCH

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

(2018) Ziming Wang et al.   NATURE MEDICINE

Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy

(2018) Jinfang Zhang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mouse Models for Cancer Immunotherapy Research

(2018) Brian Olson et al.   Cancer Discovery

The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

(2017) Bertrand Allard et al.   IMMUNOLOGICAL REVIEWS

Glutamine Administration in Early or Late Septic Phase Downregulates Lymphocyte PD-1/PD-L1 Expression and the Inflammatory Response in Mice With Polymicrobial Sepsis

(2017) Ya-Mei Hu et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells

(2017) J Feng et al.   ONCOGENE

Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe?

(2017) Yanqing Huang et al.   Science China-Life Sciences

Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation

(2017) Yapeng Ji et al.   Nature Communications

Masterful Antibodies: Checkpoint Blockade

(2017) Nils Lonberg et al.   Cancer Immunology Research

Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors

(2017) Eva M. Palsson-McDermott et al.   Frontiers in Immunology

Identifying Regulatory Posttranslational Modifications of PD-L1: A Focus on Monoubiquitinaton

(2017) Henrick Horita et al.   NEOPLASIA

Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways

(2017) et al.   Cancers

PKM2, cancer metabolism, and the road ahead

(2016) Talya L Dayton et al.   EMBO REPORTS

The EGFR pathway is involved in the regulation of PD-L1 expression via the IL-6/JAK/STAT3 signaling pathway in EGFR-mutated non-small cell lung cancer

(2016) Nan Zhang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

(2016) Wei Yang et al.   NATURE

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia

(2016) Nicole E. Scharping et al.   Cancer Immunology Research

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+T cells

(2015) Pamela M. Odorizzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes

(2015)   Oncotarget

Galectin-1 links tumor hypoxia and radiotherapy

(2014) P. Kuo et al.   GLYCOBIOLOGY

Synergistic effects of IL-4 and TNFα on the induction of B7-H1 in renal cell carcinoma cells inhibiting allogeneic T cell proliferation

(2014) Dagmar Quandt et al.   Journal of Translational Medicine

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1 

(2014) B. Faubert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

(2014) Limo Chen et al.   Nature Communications

In Vitro Characterization of the Anti-PD-1 Antibody Nivolumab, BMS-936558, and In Vivo Toxicology in Non-Human Primates

(2014) C. Wang et al.   Cancer Immunology Research

Hostile, Hypoxia-A2-Adenosinergic Tumor Biology as the Next Barrier to Overcome for Tumor Immunologists

(2014) M. V. Sitkovsky et al.   Cancer Immunology Research

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs

(2013) B. Allard et al.   CLINICAL CANCER RESEARCH

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Suppression of Acute Graft-Versus-Host Response by TCDD Is Independent of the CTLA-4-IFN-γ-IDO pathway

(2013) Diana Rohlman et al.   TOXICOLOGICAL SCIENCES

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

(2012) Anne Le et al.   Cell Metabolism

Constitutive AP-1 Activity and EBV Infection Induce PD-L1 in Hodgkin Lymphomas and Posttransplant Lymphoproliferative Disorders: Implications for Targeted Therapy

(2012) M. R. Green et al.   CLINICAL CANCER RESEARCH

Alterations of metabolic genes and metabolites in cancer

(2012) Eric K. Oermann et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The development and immunosuppressive functions of CD4+ CD25+ FoxP3+ regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway

(2012) Akio Ohta et al.   Frontiers in Immunology

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation

(2011) Anna N. Mendler et al.   INTERNATIONAL JOURNAL OF CANCER

HBcAg induces PD-1 upregulation on CD4+T cells through activation of JNK, ERK and PI3K/AKT pathways in chronic hepatitis-B-infected patients

(2011) Man Li et al.   LABORATORY INVESTIGATION

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

Spatiotemporal Basis of CTLA-4 Costimulatory Molecule-Mediated Negative Regulation of T Cell Activation

(2010) Tadashi Yokosuka et al.   IMMUNITY

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation

(2010) E. L. Carr et al.   JOURNAL OF IMMUNOLOGY

TNF-α, a potent lipid metabolism regulator

(2009) Xiuping Chen et al.   CELL BIOCHEMISTRY AND FUNCTION

Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling

(2009) Tobias Zech et al.   EMBO JOURNAL

CD28 and CTLA-4 coreceptor expression and signal transduction

(2009) Christopher E. Rudd et al.   IMMUNOLOGICAL REVIEWS

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

CTLA-4 trafficking and surface expression

(2008) Elke Valk et al.   TRENDS IN IMMUNOLOGY