Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα

SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells

(2021) Yingying Tong et al.   MOLECULAR CELL

Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

(2021) Xiaoming Dai et al.   MOLECULAR CELL

Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets

(2021) Rui Liu et al.   MOLECULAR CELL

Programmable base editing of mutated TERT promoter inhibits brain tumour growth

(2020) Xinjian Li et al.   NATURE CELL BIOLOGY

Next-generation immuno-oncology agents: current momentum shifts in cancer immunotherapy

(2020) Chongxian Pan et al.   Journal of Hematology & Oncology

The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis

(2020) Daqian Xu et al.   NATURE

Clinical Challenges of Immune Checkpoint Inhibitors

(2020) Maria de Miguel et al.   CANCER CELL

β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion

(2020) Linyong Du et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of PD-L1 Expression by NF-κB in Cancer

(2020) Fabrizio Antonangeli et al.   Frontiers in Immunology

The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62

(2019) Daqian Xu et al.   Science Advances

A tumor agnostic therapeutic strategy for Hexokinase 1 Null/Hexokinase 2 positive cancers

(2019) Shili Xu et al.   CANCER RESEARCH

PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1

(2019) Xu Qian et al.   MOLECULAR CELL

The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation

(2018) Mir Hussain Nawaz et al.   BIOSCIENCE REPORTS

EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation

(2018) Jong-Ho Lee et al.   MOLECULAR CELL

Metabolic Kinases Moonlighting as Protein Kinases

(2018) Zhimin Lu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Unlocking the potential of HK2 in cancer metabolism and therapeutics

(2018) Sara N. Garcia et al.   CURRENT MEDICINAL CHEMISTRY

Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA

(2017) Matthew A. Coelho et al.   IMMUNITY

Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy

(2017) Xu Qian et al.   MOLECULAR CELL

Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

(2017) Jinfang Zhang et al.   NATURE

Deubiquitination and Stabilization of PD-L1 by CSN5

(2016) Seung-Oe Lim et al.   CANCER CELL

Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

(2016) Andrea J. Wolf et al.   CELL

Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis

(2016) Xinjian Li et al.   MOLECULAR CELL

A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation

(2016) Xinjian Li et al.   NATURE CELL BIOLOGY

Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway

(2016) Vassiliki A. Boussiotis   NEW ENGLAND JOURNAL OF MEDICINE

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity

(2016) R. D. Dorand et al.   SCIENCE

Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

(2016) Chia-Wei Li et al.   Nature Communications

Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation

(2015) Yanhua Zheng et al.   NATURE CELL BIOLOGY

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

(2014) Roy S. Herbst et al.   NATURE

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

(2012) Weiwei Yang et al.   CELL

EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-κB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis

(2012) Weiwei Yang et al.   MOLECULAR CELL

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Subcellular Localization of Hexokinases I and II Directs the Metabolic Fate of Glucose

(2011) Scott John et al.   PLoS One