Cystine–glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

(2018) Tsadik Habtetsion et al.   Cell Metabolism

xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression

(2018) Xiangming Ji et al.   ONCOGENE

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

(2018) Amy Tarangelo et al.   Cell Reports

Glutathione Primes T Cell Metabolism for Inflammation

(2017) Tak W. Mak et al.   IMMUNITY

Absence of system xc − on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis

(2017) Ellen Merckx et al.   Journal of Neuroinflammation

Cysteine Dioxygenase 1 Mediates Erastin-Induced Ferroptosis in Human Gastric Cancer Cells

(2017) Shihui Hao et al.   NEOPLASIA

CTLA-4 and PD-1 Pathways

(2016) Elizabeth I. Buchbinder et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes

(2016) Peter J. Siska et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Rational Selection of Syngeneic Preclinical Tumor Models for Immunotherapeutic Drug Discovery

(2016) Suzanne I.S. Mosely et al.   Cancer Immunology Research

Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8+ T cell function by limiting GSH and Cys availability

(2015) Lisa K. Sha et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of SystemXc−Transporter Attenuates Autoimmune Inflammatory Demyelination

(2015) Kirsten S. Evonuk et al.   JOURNAL OF IMMUNOLOGY

Human CD4+ T cells require exogenous cystine for glutathione and DNA synthesis

(2015) Trine B. Levring et al.   Oncotarget

IGF-I Regulates Redox Status in Breast Cancer Cells by Activating the Amino Acid Transport Molecule xC−

(2014) Yuzhe Yang et al.   CANCER RESEARCH

Targeting xCT, a cystine-glutamate transporter induces apoptosis and tumor regression for KSHV/HIV-associated lymphoma

(2014) Lu Dai et al.   Journal of Hematology & Oncology

Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response

(2014) P. Kvistborg et al.   Science Translational Medicine

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activated human CD4+ T cells express transporters for both cysteine and cystine

(2012) Trine Bøegh Levring et al.   Scientific Reports

Disruption of xCT inhibits cell growth via the ROS/autophagy pathway in hepatocellular carcinoma

(2011) Weijie Guo et al.   CANCER LETTERS

A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis

(2011) Christopher Chidley et al.   Nature Chemical Biology

The Human Serum Metabolome

(2011) Nikolaos Psychogios et al.   PLoS One

Differential Dependence on Cysteine from Transsulfuration versus Transport During T Cell Activation

(2010) Sanjay K. Garg et al.   ANTIOXIDANTS & REDOX SIGNALING

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

xCT deficiency accelerates chemically induced tumorigenesis

(2010) A. Nabeyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL