NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion

p53-suppressed oncogene TET1 prevents cellular aging in lung cancer

(2019) Piotr T. Filipczak et al.   CANCER RESEARCH

NAD+ metabolism governs the proinflammatory senescence-associated secretome

(2019) Timothy Nacarelli et al.   NATURE CELL BIOLOGY

Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells

(2019) Cristina Travelli et al.   CANCER RESEARCH

Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma

(2019) Jiabin Cai et al.   GUT

Non-catalytic Roles of Tet2 Are Essential to Regulate Hematopoietic Stem and Progenitor Cell Homeostasis

(2019) Kyoko Ito et al.   Cell Reports

Pivotal role of NAMPT in the switch of melanoma cells toward an invasive and drug-resistant phenotype

(2018) Mickaël Ohanna et al.   GENES & DEVELOPMENT

Interleukin-10 Directly Inhibits CD8 + T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity

(2018) Logan K. Smith et al.   IMMUNITY

DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade

(2018) Mehdi Touat et al.   JOURNAL OF CLINICAL INVESTIGATION

Decitibine improve the efficiency of anti-PD-1 therapy via activating the response to IFN/PD-L1 signal of lung cancer cells

(2018) Qi Lai et al.   ONCOGENE

α-ketoglutarate dehydrogenase inhibition counteracts breast cancer-associated lung metastasis

(2018) Sandra Atlante et al.   Cell Death & Disease

CD38-mediated immunosuppression as a mechanism of tumor cell escape from PD-1/PD-L1 blockade

(2018) Limo Chen et al.   Cancer Discovery

Immunity drives TET1 regulation in cancer through NF-κB

(2018) Evelyne Collignon et al.   Science Advances

Global DNA 5-hydroxymethylcytosine and 5-formylcytosine contents are decreased in the early stage of hepatocellular carcinoma

(2018) Jiao Liu et al.   HEPATOLOGY

HCCDB: A Database of Hepatocellular Carcinoma Expression Atlas

(2018) Qiuyu Lian et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma

(2018) Otília Menyhárt et al.   Royal Society Open Science

Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA

(2017) Matthew A. Coelho et al.   IMMUNITY

Nicotinamide Phosphoribosyltransferase (NAMPT) as a Therapeutic Target in BRAF-Mutated Metastatic Melanoma

(2017) Valentina Audrito et al.   JNCI-Journal of the National Cancer Institute

Targeting the vulnerability to NAD+ depletion in B-cell acute lymphoblastic leukemia

(2017) S Takao et al.   LEUKEMIA

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

(2017) Riccardo Mezzadra et al.   NATURE

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

(2017) Marian L. Burr et al.   NATURE

Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity

(2017) Jing Wang et al.   NUCLEIC ACIDS RESEARCH

LinkedOmics: analyzing multi-omics data within and across 32 cancer types

(2017) Suhas V Vasaikar et al.   NUCLEIC ACIDS RESEARCH

Emerging targets in cancer immunotherapy

(2017) Samantha Burugu et al.   SEMINARS IN CANCER BIOLOGY

Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia

(2017) Xi Jiang et al.   Nature Communications

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade

(2017) Pornpimol Charoentong et al.   Cell Reports

Nicotinamide Phosphoribosyltransferase (NAMPT) as a Therapeutic Target in BRAF-Mutated Metastatic Melanoma

(2017) Valentina Audrito et al.   JNCI-Journal of the National Cancer Institute

Extracellular nicotinamide phosphoribosyltransferase, a new cancermetabokine

(2016) Ambra A Grolla et al.   BRITISH JOURNAL OF PHARMACOLOGY

Deubiquitination and Stabilization of PD-L1 by CSN5

(2016) Seung-Oe Lim et al.   CANCER CELL

Targeting T Cell Co-receptors for Cancer Therapy

(2016) Margaret K. Callahan et al.   IMMUNITY

What does PD-L1 positive or negative mean?

(2016) Antoni Ribas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumour hypoxia causes DNA hypermethylation by reducing TET activity

(2016) Bernard Thienpont et al.   NATURE

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma

(2016) Amit D. Gujar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion

(2015) Kensuke Tateishi et al.   CANCER CELL

IL10 and PD-1 Cooperate to Limit the Activity of Tumor-Specific CD8+ T Cells

(2015) Z. Sun et al.   CANCER RESEARCH

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

PD-L1 Expression as a Predictive Biomarker in Cancer Immunotherapy

(2015) S. P. Patel et al.   MOLECULAR CANCER THERAPEUTICS

Physiological and pathophysiological roles of NAMPT and NAD metabolism

(2015) Antje Garten et al.   Nature Reviews Endocrinology

Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer

(2015) Edward B. Garon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pembrolizumab versus Ipilimumab in Advanced Melanoma

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

NAD+ in aging, metabolism, and neurodegeneration

(2015) E. Verdin   SCIENCE

Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway

(2015) Kim C. Ohaegbulam et al.   TRENDS IN MOLECULAR MEDICINE

Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia

(2014) Valentina Audrito et al.   BLOOD

MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer

(2014) Thomas Powles et al.   NATURE

MethHC: a database of DNA methylation and gene expression in human cancer

(2014) Wei-Yun Huang et al.   NUCLEIC ACIDS RESEARCH

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

Influence of Metabolism on Epigenetics and Disease

(2013) William G. Kaelin et al.   CELL

Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Therapeutics: Rationales, Controversies, Clinical Experience

(2013) By Fabrizio Montecucco et al.   CURRENT DRUG TARGETS

Histone Deacetylase Sirtuin 1 Deacetylates IRF1 Protein and Programs Dendritic Cells to Control Th17 Protein Differentiation during Autoimmune Inflammation

(2013) Heeyoung Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Medicinal Chemistry of Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors

(2013) Ubaldina Galli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Liquid biopsy: monitoring cancer-genetics in the blood

(2013) Emily Crowley et al.   Nature Reviews Clinical Oncology

Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

(2012) H Yang et al.   ONCOGENE

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

NAMPT in Regulated NAD Biosynthesis and its Pivotal Role in Human Metabolism

(2011) E S. Burgos   CURRENT MEDICINAL CHEMISTRY

Nicotinamide adenine dinucleotide (NAD)-regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus

(2010) J. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A phosphorylation-acetylation switch regulates STAT1 signaling

(2009) O. H. Kramer et al.   GENES & DEVELOPMENT

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE