IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response
出版年份 2019 全文链接
标题
IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response
作者
关键词
-
出版物
Science Translational Medicine
Volume 11, Issue 479, Pages eaaq1427
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2019-02-14
DOI
10.1126/scitranslmed.aaq1427
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Mutant IDH1 regulates the tumor-associated immune system in gliomas
- (2017) Nduka M. Amankulor et al. GENES & DEVELOPMENT
- Genetic driver mutations define the expression signature and microenvironmental composition of high-grade gliomas
- (2017) C. J. Herting et al. GLIA
- 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity
- (2017) Parker L. Sulkowski et al. Science Translational Medicine
- The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
- (2016) David N. Louis et al. ACTA NEUROPATHOLOGICA
- Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2
- (2016) Satoshi Inoue et al. CANCER CELL
- Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
- (2016) Michele Ceccarelli et al. CELL
- IDH mutation is associated with higher risk of malignant transformation in low-grade glioma
- (2016) Severina Leu et al. JOURNAL OF NEURO-ONCOLOGY
- Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma
- (2016) Jan C. Buckner et al. NEW ENGLAND JOURNAL OF MEDICINE
- ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma
- (2016) Carl Koschmann et al. Science Translational Medicine
- Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells
- (2016) K. M. Godek et al. Cancer Discovery
- Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198
- (2015) R. J. Molenaar et al. CANCER RESEARCH
- Historical perspective on the DNA damage response
- (2015) Philip C. Hanawalt DNA REPAIR
- Integrated genomic characterization of IDH1-mutant glioma malignant progression
- (2015) Hanwen Bai et al. NATURE GENETICS
- Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas
- (2015) NEW ENGLAND JOURNAL OF MEDICINE
- IDH1R132H mutation causes a less aggressive phenotype and radiosensitizes human malignant glioma cells independent of the oxygenation status
- (2015) Jacqueline Kessler et al. RADIOTHERAPY AND ONCOLOGY
- Broad-Enrich: functional interpretation of large sets of broad genomic regions
- (2014) Raymond G. Cavalcante et al. BIOINFORMATICS
- Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in IDH-Mutant Gliomas
- (2014) H. Wakimoto et al. CLINICAL CANCER RESEARCH
- Modeling Adult Gliomas Using RCAS/t-va Technology
- (2014) Dolores Hambardzumyan et al. Translational Oncology
- Use of Bru-Seq and BruChase-Seq for genome-wide assessment of the synthesis and stability of RNA
- (2013) Michelle T. Paulsen et al. METHODS
- Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma
- (2013) B. E. Johnson et al. SCIENCE
- Cancer Genome Landscapes
- (2013) B. Vogelstein et al. SCIENCE
- An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells
- (2013) D. Rohle et al. SCIENCE
- IDH mutation impairs histone demethylation and results in a block to cell differentiation
- (2012) Chao Lu et al. NATURE
- IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
- (2012) Sevin Turcan et al. NATURE
- Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation
- (2012) Sichen Li et al. NEURO-ONCOLOGY
- Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia
- (2012) Jay P. Patel et al. NEW ENGLAND JOURNAL OF MEDICINE
- Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
- (2011) Wei Xu et al. CANCER CELL
- Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells
- (2011) H. Wakimoto et al. NEURO-ONCOLOGY
- Altered Telomeres in Tumors with ATRX and DAXX Mutations
- (2011) C. M. Heaphy et al. SCIENCE
- Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
- (2010) Maria E. Figueroa et al. CANCER CELL
- IDH1 and IDH2 Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia With NPM1 Mutation Without FLT3 Internal Tandem Duplication
- (2010) Peter Paschka et al. JOURNAL OF CLINICAL ONCOLOGY
- Homologous Recombination Conserves DNA Sequence Integrity Throughout the Cell Cycle in Embryonic Stem Cells
- (2010) Lourdes Serrano et al. STEM CELLS AND DEVELOPMENT
- IDH1 Mutations Are Early Events in the Development of Astrocytomas and Oligodendrogliomas
- (2009) Takuya Watanabe et al. AMERICAN JOURNAL OF PATHOLOGY
- De novo Induction of Genetically Engineered Brain Tumors in Mice Using Plasmid DNA
- (2009) S. M. Wiesner et al. CANCER RESEARCH
- ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays
- (2009) Yifang Hu et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
- (2009) Lenny Dang et al. NATURE
- The DNA-damage response in human biology and disease
- (2009) Stephen P. Jackson et al. NATURE
- DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity
- (2009) Jeremy D Henson et al. NATURE BIOTECHNOLOGY
- IDH1andIDH2Mutations in Gliomas
- (2009) Hai Yan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Comprehensive genomic characterization defines human glioblastoma genes and core pathways
- (2008) Roger McLendon et al. NATURE
- An Integrated Genomic Analysis of Human Glioblastoma Multiforme
- (2008) D. W. Parsons et al. SCIENCE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started