Glutamine deprivation impairs function of infiltrating CD8+ T cells in hepatocellular carcinoma by inducing mitochondrial damage and apoptosis

Interplay within tumor microenvironment orchestrates neoplastic RNA metabolism and transcriptome diversity

(2021) Subhashis Natua et al.   Wiley Interdisciplinary Reviews-RNA

Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells

(2021) Yifan Xie et al.   Advanced Science

Silibinin-induced mitochondria fission leads to mitophagy, which attenuates silibinin-induced apoptosis in MCF-7 and MDA-MB-231 cells

(2020) Lingling Si et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cellular and Extracellular Components in Tumor Microenvironment and Their Application in Early Diagnosis of Cancers

(2020) Rui Wei et al.   Analytical Cellular Pathology

High Levels of ROS Impair Lysosomal Acidity and Autophagy Flux in Glucose-Deprived Fibroblasts by Activating ATM and Erk Pathways

(2020) Seon Beom Song et al.   Biomolecules

Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion

(2020) Yi-Ru Yu et al.   NATURE IMMUNOLOGY

Mitochondrial Damage and the Road to Exhaustion

(2020) Wenhui Li et al.   Cell Metabolism

Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth

(2019) Sameer H. Issaq et al.   Oncogenesis

Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization

(2019) Lisha Xiang et al.   Cell Death & Disease

Navigating metabolic pathways to enhance antitumour immunity and immunotherapy

(2019) Xiaoyun Li et al.   Nature Reviews Clinical Oncology

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

(2019) Omar Khan et al.   NATURE

PD1Hi CD8+ T cells correlate with exhausted signature and poor clinical outcome in hepatocellular carcinoma

(2019) Jiaqiang Ma et al.   Journal for ImmunoTherapy of Cancer

Combining α-Hederin with cisplatin increases the apoptosis of gastric cancer in vivo and in vitro via mitochondrial related apoptosis pathway

(2019) Huan Deng et al.   BIOMEDICINE & PHARMACOTHERAPY

Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation

(2018) Vinicius Cruzat et al.   Nutrients

Mitochondrial division inhibitor-1 potentiates cisplatin-induced apoptosis via the mitochondrial death pathway in cholangiocarcinoma cells

(2018) Ornanong Tusskorn et al.   BIOMEDICINE & PHARMACOTHERAPY

Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-Infiltrating T Cells in Hepatocellular Carcinomas

(2017) Guoying Zhou et al.   GASTROENTEROLOGY

Delineation of an immunosuppressive gradient in hepatocellular carcinoma using high-dimensional proteomic and transcriptomic analyses

(2017) Valerie Chew et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

(2014) Valerie A. Gerriets et al.   JOURNAL OF CLINICAL INVESTIGATION

Tolerance and exhaustion: defining mechanisms of T cell dysfunction

(2013) Andrea Schietinger et al.   TRENDS IN IMMUNOLOGY

Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory

(2012) Travis A. Doering et al.   IMMUNITY