STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation

Distribution of BCG-CWS loaded nanoparticles in the spleen after intravenous injection affects cytotoxic T lymphocyte activity

(2020) Hideyuki Masuda et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Poor outcome with anti-programmed death-ligand 1 (PD-L1) antibody due to poor pharmacokinetic properties in PD-1/PD-L1 blockade-sensitive mouse models

(2020) Taiki Kurino et al.   Journal for ImmunoTherapy of Cancer

NK cells mediate clearance of CD8+ T cell–resistant tumors in response to STING agonists

(2020) Christopher J. Nicolai et al.   Science Immunology

Co-delivery of Peptide Neoantigens and Stimulator of Interferon Genes Agonists Enhances Response to Cancer Vaccines

(2020) Daniel Shae et al.   ACS Nano

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

(2019) Daniel Shae et al.   Nature Nanotechnology

Neoantigen-directed immune escape in lung cancer evolution

(2019) Rachel Rosenthal et al.   NATURE

STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition

(2019) Sabrina L. Ergun et al.   CELL

STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus

(2019) Pia-Katharina Tegtmeyer et al.   Nature Communications

SLC19A1 transports immunoreactive cyclic dinucleotides

(2019) Rutger D. Luteijn et al.   NATURE

The cGAS-STING pathway is a therapeutic target in a preclinical model of hepatocellular carcinoma

(2019) Martin K. Thomsen et al.   ONCOGENE

An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases

(2019) Yang Liu et al.   Nature Communications

The silencing of indoleamine 2,3-dioxygenase 1 (IDO1) in dendritic cells by siRNA-loaded lipid nanoparticles enhances cell-based cancer immunotherapy

(2019) Rikito Endo et al.   Scientific Reports

Immune Responses in the Liver

(2018) Paul Kubes et al.   Annual Review of Immunology

The transition from HLA-I positive to HLA-I negative primary tumors: the road to escape from T-cell responses

(2018) Natalia Aptsiauri et al.   CURRENT OPINION IN IMMUNOLOGY

Reducing the Cytotoxicity of Lipid Nanoparticles Associated with a Fusogenic Cationic Lipid in a Natural Killer Cell Line by Introducing a Polycation-Based siRNA Core

(2018) Takashi Nakamura et al.   MOLECULAR PHARMACEUTICS

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade

(2018) Joy Hsu et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response

(2018) Assaf Marcus et al.   IMMUNITY

PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy

(2018) Dmitriy Zamarin et al.   JOURNAL OF CLINICAL INVESTIGATION

Application of BCG-CWS as a Systemic Adjuvant by Using Nanoparticulation Technology

(2018) Hideyuki Masuda et al.   MOLECULAR PHARMACEUTICS

Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance

(2018) Yong Liang et al.   Nature Communications

Identification of a subset of human natural killer cells expressing high levels of programmed death 1: A phenotypic and functional characterization

(2017) Silvia Pesce et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity

(2017) Vikram R. Juneja et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A STING-activating nanovaccine for cancer immunotherapy

(2017) Min Luo et al.   Nature Nanotechnology

Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers

(2017) Y Liu et al.   ONCOGENE

In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy

(2017) Sean P. Arlauckas et al.   Science Translational Medicine

Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure)

(2016) J. M. Kim et al.   ANNALS OF ONCOLOGY

A lipid nanoparticle for the efficient delivery of siRNA to dendritic cells

(2016) Shota Warashina et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination

(2016) Yi-Nan Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Design, Synthesis, and Biological Evaluation of Novel Cyclic Adenosine–Inosine Monophosphate (cAIMP) Analogs That Activate Stimulator of Interferon Genes (STING)

(2016) Thierry Lioux et al.   JOURNAL OF MEDICINAL CHEMISTRY

Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

(2016) Olivier De Henau et al.   NATURE

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Small-sized, stable lipid nanoparticle for the efficient delivery of siRNA to human immune cell lines

(2016) Takashi Nakamura et al.   Scientific Reports

Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth

(2015) Sonja Kleffel et al.   CELL

Nanoparticulate STING agonists are potent lymph node–targeted vaccine adjuvants

(2015) Melissa C. Hanson et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti–PD-1/PD-L1 therapy of human cancer: past, present, and future

(2015) Lieping Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma

(2015) Takashi Nakamura et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticle uptake: The phagocyte problem

(2015) Heather Herd Gustafson et al.   Nano Today

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

A new adjuvant delivery system ‘cyclic di-GMP/YSK05 liposome’ for cancer immunotherapy

(2014) Hiroko Miyabe et al.   JOURNAL OF CONTROLLED RELEASE

The Spleen in Local and Systemic Regulation of Immunity

(2013) Vincenzo Bronte et al.   IMMUNITY

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

The nanoparticulation by octaarginine-modified liposome improves α-galactosylceramide-mediated antitumor therapy via systemic administration

(2013) Takashi Nakamura et al.   JOURNAL OF CONTROLLED RELEASE

Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells

(2013) S. Spranger et al.   Science Translational Medicine

Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles

(2012) Z. Garcia et al.   BLOOD

A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo

(2012) Yusuke Sato et al.   JOURNAL OF CONTROLLED RELEASE

Host type I IFN signals are required for antitumor CD8+T cell responses through CD8α+dendritic cells

(2011) Mercedes B. Fuertes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA

(2011) Federico Perche et al.   Nanomedicine-Nanotechnology Biology and Medicine

The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody

(2010) D. M. Benson et al.   BLOOD

The Liver as a Lymphoid Organ

(2009) Ian Nicholas Crispe   Annual Review of Immunology

HIV-Induced Type I Interferon and Tryptophan Catabolism Drive T Cell Dysfunction Despite Phenotypic Activation

(2008) Adriano Boasso et al.   PLoS One

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

(2008) K. Hildner et al.   SCIENCE