Subcellular regulation of glucose metabolism through multienzyme glucosome assemblies by EGF-ERK1/2 signaling pathways

Metabolic regulation of cell growth and proliferation

(2019) Jiajun Zhu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2

(2019) Laurel M. Pegram et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer

(2019) Kai Li et al.   CELL RESEARCH

A Mathematical Model for Enzyme Clustering in Glucose Metabolism

(2018) Miji Jeon et al.   Scientific Reports

Identification of a multienzyme complex for glucose metabolism in living cells

(2017) Casey L. Kohnhorst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis

(2017) Jia Zhang et al.   Nature Communications

Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis

(2017) Jong-Ho Lee et al.   Nature Communications

Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways

(2017) et al.   Cancers

EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape

(2016) S.-O. Lim et al.   CANCER RESEARCH

Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis

(2016) Xinjian Li et al.   MOLECULAR CELL

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

(2016) Michael E Pacold et al.   Nature Chemical Biology

A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics

(2014) Apirat Chaikuad et al.   Nature Chemical Biology

Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation

(2013) X. Deschenes-Simard et al.   GENES & DEVELOPMENT

Akt Phosphorylates HK-II at Thr-473 and Increases Mitochondrial HK-II Association to Protect Cardiomyocytes

(2013) David J. Roberts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Akt-dependent Activation of the Heart 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase (PFKFB2) Isoenzyme by Amino Acids

(2013) Laura Novellasdemunt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of a Novel ERK Inhibitor with Activity in Models of Acquired Resistance to BRAF and MEK Inhibitors

(2013) E. J. Morris et al.   Cancer Discovery

Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals

(2012) John G. Albeck et al.   MOLECULAR CELL

Network Analysis of Epidermal Growth Factor Signaling Using Integrated Genomic, Proteomic and Phosphorylation Data

(2012) Katrina M. Waters et al.   PLoS One

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen

(2008) John M. Asara et al.   PROTEOMICS

Reversible Compartmentalization of de Novo Purine Biosynthetic Complexes in Living Cells

(2008) S. An et al.   SCIENCE