ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia

Serine biosynthesis is a metabolic vulnerability in FLT3-ITD-driven acute myeloid leukaemia

(2021) Stefan Bjelosevic et al.   Cancer Discovery

BRCA1 Mutational Complementation Induces Synthetic Viability

(2020) Joseph Nacson et al.   MOLECULAR CELL

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

(2020) Bryan Ngo et al.   Cancer Discovery

Targeting Glutamine Metabolism and Redox State for Leukemia Therapy

(2019) Mark A. Gregory et al.   CLINICAL CANCER RESEARCH

Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia

(2019) Lucille Stuani et al.   BMC BIOLOGY

Metabolic Plasticity of Acute Myeloid Leukemia

(2019) Kreitz et al.   Cells

Targeting Metabolic Reprogramming in Acute Myeloid Leukemia

(2019) Isabel Castro et al.   Cells

Glutaminolysis is a metabolic dependency in FLT3ITDacute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

(2018) Paolo Gallipoli et al.   BLOOD

Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism

(2018) Xia Gao et al.   Cell Reports

Role of activating transcription factor 3 and its interacting proteins under physiological and pathological conditions

(2018) M. Rohini et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

(2018) Courtney L. Jones et al.   CANCER CELL

Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism

(2018) Michael A. Reid et al.   Nature Communications

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

(2017) Simon Raffel et al.   NATURE

The Encyclopedia of DNA elements (ENCODE): data portal update

(2017) Carrie A Davis et al.   NUCLEIC ACIDS RESEARCH

Serine and Functional Metabolites in Cancer

(2017) Alice C. Newman et al.   TRENDS IN CELL BIOLOGY

A Critical Balance: dNTPs and the Maintenance of Genome Stability

(2017) Chen‐Chun Pai et al.   Genes

Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway

(2016) Gregory S. Ducker et al.   Cell Metabolism

The importance of serine metabolism in cancer

(2016) Katherine R. Mattaini et al.   JOURNAL OF CELL BIOLOGY

JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia

(2016) C Zhou et al.   LEUKEMIA

Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells

(2016) Oliver D.K. Maddocks et al.   MOLECULAR CELL

Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53

(2016) Romain Riscal et al.   MOLECULAR CELL

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism

(2016) Erhu Zhao et al.   Cell Reports

Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications

(2015) Rebecca Kohnken et al.   Molecular Cancer

NRF2 regulates serine biosynthesis in non–small cell lung cancer

(2015) Gina M DeNicola et al.   NATURE GENETICS

BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis

(2015) Frederik Otzen Bagger et al.   NUCLEIC ACIDS RESEARCH

Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia

(2014) Jeffery M. Klco et al.   CANCER CELL

p53 Protein-mediated Regulation of Phosphoglycerate Dehydrogenase (PHGDH) Is Crucial for the Apoptotic Response upon Serine Starvation

(2014) Yang Ou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells

(2014) Christiaan F. Labuschagne et al.   Cell Reports

Genomic impact of transient low-dose decitabine treatment on primary AML cells

(2013) J. M. Klco et al.   BLOOD

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Factorbook.org: a Wiki-based database for transcription factor-binding data generated by the ENCODE consortium

(2012) J. Wang et al.   NUCLEIC ACIDS RESEARCH

Leukemia Gene Atlas – A Public Platform for Integrative Exploration of Genome-Wide Molecular Data

(2012) Katja Hebestreit et al.   PLoS One

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

ATF3 transcription factor and its emerging roles in immunity and cancer

(2009) Matthew R. Thompson et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells

(2009) Q. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia

(2008) K. H. Metzeler et al.   BLOOD

Activating Transcription Factor 3 Is a Novel Repressor of the Nuclear Factor Erythroid-Derived 2 Related Factor 2 (Nrf2) Regulated Stress Pathway

(2008) S. L. Brown et al.   CANCER RESEARCH

Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling

(2008) R. G.W. Verhaak et al.   HAEMATOLOGICA

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH