Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria

Palmitoylation couples insulin hypersecretion with β cell failure in diabetes

(2023) Guifang Dong et al.   Cell Metabolism

Inhibition of fatty acid translocase (FAT/CD36) palmitoylation enhances hepatic fatty acid β-oxidation by increasing its localization to mitochondria and interaction with long-chain acyl-CoA synthetase 1

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Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease

(2022) Richard G Lee et al.   HUMAN MOLECULAR GENETICS

Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling

(2022) Megan J. Agajanian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DHHC17 Is a New Regulator of AMPK Signaling

(2022) Yingmin Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes

(2022) Froukje Vanweert et al.   Nature Communications

A Randomized Trial of Enteral Glutamine for Treatment of Burn Injuries

(2022) Daren K. Heyland et al.   NEW ENGLAND JOURNAL OF MEDICINE

Q-Flux: A method to assess hepatic mitochondrial succinate dehydrogenase, methylmalonyl-CoA mutase, and glutaminase fluxes in vivo

(2022) Brandon T. Hubbard et al.   Cell Metabolism

Endosomal lipid signaling reshapes the endoplasmic reticulum to control mitochondrial function

(2022) Wonyul Jang et al.   SCIENCE

Synaptic activity–dependent changes in the hippocampal palmitoylome

(2022) Glory G. Nasseri et al.   Science Signaling

Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids

(2022) Michael R. Martino et al.   Cell Reports

Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains

(2021) Laurence Abrami et al.   Nature Chemical Biology

The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine

(2021) Deyang Yu et al.   Cell Metabolism

Leigh Syndrome: A Tale of Two Genomes

(2021) Ajibola B. Bakare et al.   Frontiers in Physiology

Branched-chain Amino Acids: Catabolism in Skeletal Muscle and Implications for Muscle and Whole-body Metabolism

(2021) Gagandeep Mann et al.   Frontiers in Physiology

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context

(2021) Marcel Morgenstern et al.   Cell Metabolism

Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol, and rapamycin

(2021) David G. Le Couteur et al.   Cell Metabolism

CRLS1 ameliorates nonalcoholic steatohepatitis through ATF3 transcriptional inactivation

(2020) Chuyue Tu et al.   HEPATOLOGY

Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease

(2020) Xiaochao Wei et al.   CIRCULATION RESEARCH

Pathogenic variants in SQOR encoding sulfide:quinone oxidoreductase are a potentially treatable cause of Leigh disease

(2020) Marisa W. Friederich et al.   JOURNAL OF INHERITED METABOLIC DISEASE

A STAT3 palmitoylation cycle promotes TH17 differentiation and colitis

(2020) Mingming Zhang et al.   NATURE

CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis

(2020) Jian-Wei Hao et al.   Nature Communications

DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane

(2019) Juan Wang et al.   Cell Reports

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance

(2019) Meiyi Zhou et al.   DIABETES

ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5

(2019) Yang Cao et al.   Nature Chemical Biology

A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells

(2019) Hee Chan Yoo et al.   Cell Metabolism

CalR : A Web-Based Analysis Tool for Indirect Calorimetry Experiments

(2018) Amir I. Mina et al.   Cell Metabolism

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

(2018) Elahu G. Sustarsic et al.   Cell Metabolism

Reproducible workflow for multiplexed deep-scale proteome and phosphoproteome analysis of tumor tissues by liquid chromatography–mass spectrometry

(2018) Philipp Mertins et al.   Nature Protocols

A Phase 3 Trial of l-Glutamine in Sickle Cell Disease

(2018) Yutaka Niihara et al.   NEW ENGLAND JOURNAL OF MEDICINE

Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes

(2018) Rahul S. Kathayat et al.   Nature Communications

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis

(2018) Guy Eelen et al.   NATURE

Metabolites as regulators of insulin sensitivity and metabolism

(2018) Qin Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysophospholipases Cooperate to Mediate Lipid Homeostasis and Lysophospholipid Signaling

(2018) James A. Wepy et al.   JOURNAL OF LIPID RESEARCH

Online Parallel Accumulation–Serial Fragmentation (PASEF) with a Novel Trapped Ion Mobility Mass Spectrometer

(2018) Florian Meier et al.   MOLECULAR & CELLULAR PROTEOMICS

DHHC7 Palmitoylates Glucose Transporter 4 (Glut4) and Regulates Glut4 Membrane Translocation

(2017) Keyong Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of hepatic glucose metabolism in health and disease

(2017) Max C. Petersen et al.   Nature Reviews Endocrinology

Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade

(2017) Laurence Abrami et al.   eLife

Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver

(2017) Li-Fen Shen et al.   Scientific Reports

Zdhhc13-dependent Drp1 S-palmitoylation impacts brain bioenergetics, anxiety, coordination and motor skills

(2017) Eleonora Napoli et al.   Scientific Reports

Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2)

(2016) Sang Joon Won et al.   ACS Chemical Biology

An improved smaller biotin ligase for BioID proximity labeling

(2016) Dae In Kim et al.   MOLECULAR BIOLOGY OF THE CELL

Fatty acid synthesis configures the plasma membrane for inflammation in diabetes

(2016) Xiaochao Wei et al.   NATURE

Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth

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The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice

(2016) Tara R. Richman et al.   Nature Communications

Leigh syndrome: One disorder, more than 75 monogenic causes

(2015) Nicole J. Lake et al.   ANNALS OF NEUROLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

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The LYR Factors SDHAF1 and SDHAF3 Mediate Maturation of the Iron-Sulfur Subunit of Succinate Dehydrogenase

(2014) Un Na et al.   Cell Metabolism

Loss of LRPPRC causes ATP synthase deficiency

(2014) A. Mourier et al.   HUMAN MOLECULAR GENETICS

Identification of Palmitoyltransferase and Thioesterase Enzymes That Control the Subcellular Localization of Axon Survival Factor Nicotinamide Mononucleotide Adenylyltransferase 2 (NMNAT2)

(2014) Stefan Milde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Branched-chain amino acids in metabolic signalling and insulin resistance

(2014) Christopher J. Lynch et al.   Nature Reviews Endocrinology

Dynamic Palmitoylation Links Cytosol-Membrane Shuttling of Acyl-protein Thioesterase-1 and Acyl-protein Thioesterase-2 with That of Proto-oncogene H-Ras Product and Growth-associated Protein-43

(2013) Eryan Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamine supplementation in acute pancreatitis: A meta-analysis of randomized controlled trials

(2013) Varsha Asrani et al.   PANCREATOLOGY

Palmitoylated TMX and calnexin target to the mitochondria-associated membrane

(2011) Emily M Lynes et al.   EMBO JOURNAL

Thioesterase activity and subcellular localization of acylprotein thioesterase 1/lysophospholipase 1

(2009) Tohko Hirano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome

(2009) Woranontee Weraarpachai et al.   NATURE GENETICS

Immunonutrition in critically ill patients: a systematic review and analysis of the literature

(2008) Paul E. Marik et al.   INTENSIVE CARE MEDICINE