Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes

Dynamic Protein Acylation: New Substrates, Mechanisms, and Drug Targets

(2017) Thomas Lanyon-Hogg et al.   TRENDS IN BIOCHEMICAL SCIENCES

Deactivating Fatty Acids: Acyl-CoA Thioesterase-Mediated Control of Lipid Metabolism

(2017) Veronika Tillander et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues

(2017) Michael W. Beck et al.   Chemical Science

Charting organellar importomes by quantitative mass spectrometry

(2017) Christian D. Peikert et al.   Nature Communications

Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale

(2017) Marcel Morgenstern et al.   Cell Reports

Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism

(2016) Kay Ahn et al.   ACS Chemical Biology

Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2)

(2016) Sang Joon Won et al.   ACS Chemical Biology

Identification of PSD-95 Depalmitoylating Enzymes

(2016) Norihiko Yokoi et al.   JOURNAL OF NEUROSCIENCE

A fluorescent probe for cysteine depalmitoylation reveals dynamic APT signaling

(2016) Rahul S Kathayat et al.   Nature Chemical Biology

Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway

(2016) PuiYee Chan et al.   Nature Chemical Biology

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins

(2015) Sarah E. Calvo et al.   NUCLEIC ACIDS RESEARCH

The Autodepalmitoylating Activity of APT Maintains the Spatial Organization of Palmitoylated Membrane Proteins

(2014) Nachiket Vartak et al.   BIOPHYSICAL JOURNAL

Palmitoylation of the Immunity Related GTPase, Irgm1: Impact on Membrane Localization and Ability to Promote Mitochondrial Fission

(2014) Stanley C. Henry et al.   PLoS One

S-palmitoylation represents a novel mechanism regulating the mitochondrial targeting of BAX and initiation of apoptosis

(2014) M Fröhlich et al.   Cell Death & Disease

The role of palmitoylation in regulating Ras localization and function

(2013) Sharon Eisenberg et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Profiling and inhibiting reversible palmitoylation

(2013) Jeannie L Hernandez et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Dynamic Palmitoylation Links Cytosol-Membrane Shuttling of Acyl-protein Thioesterase-1 and Acyl-protein Thioesterase-2 with That of Proto-oncogene H-Ras Product and Growth-associated Protein-43

(2013) Eryan Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2-Bromopalmitate Analogues as Activity-Based Probes To Explore Palmitoyl Acyltransferases

(2013) Baohui Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palmitate-induced Activation of Mitochondrial Metabolism Promotes Oxidative Stress and Apoptosis in H4IIEC3 Rat Hepatocytes

(2013) Robert A. Egnatchik et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Preparation and use of MitoPY1 for imaging hydrogen peroxide in mitochondria of live cells

(2013) Bryan C Dickinson et al.   Nature Protocols

Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation

(2013) Dahvid Davda et al.   MedChemComm

Confirming Target Engagement for Reversible Inhibitors in Vivo by Kinetically Tuned Activity-Based Probes

(2012) Alexander Adibekian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system

(2012) Yusuke Ohno et al.   MOLECULAR BIOLOGY OF THE CELL

Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance

(2012) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model

(2012) H. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria-Targeted Small Molecule Therapeutics and Probes

(2011) Robin A.J. Smith et al.   ANTIOXIDANTS & REDOX SIGNALING

The Metabolic Serine Hydrolases and Their Functions in Mammalian Physiology and Disease

(2011) Jonathan Z. Long et al.   CHEMICAL REVIEWS

The Relative Rates of Thiol–Thioester Exchange and Hydrolysis for Alkyl and Aryl Thioalkanoates in Water

(2011) Paul J. Bracher et al.   ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES

Palmitoylation of ketogenic enzyme HMGCS2 enhances its interaction with PPARα and transcription at the Hmgcs2 PPRE

(2010) Morris A. Kostiuk et al.   FASEB JOURNAL

Small-molecule inhibition of APT1 affects Ras localization and signaling

(2010) Frank J Dekker et al.   Nature Chemical Biology

Proteome profile of functional mitochondria from human skeletal muscle using one-dimensional gel electrophoresis and HPLC-ESI-MS/MS

(2009) Natalie Lefort et al.   Journal of Proteomics

Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

(2009) Mariusz R Wieckowski et al.   Nature Protocols

Subcellular targeting strategies for drug design and delivery

(2009) Lawrence Rajendran et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting lipophilic cations to mitochondria

(2008) Michael P. Murphy   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A Targetable Fluorescent Probe for Imaging Hydrogen Peroxide in the Mitochondria of Living Cells

(2008) Bryan C. Dickinson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Systematic characterization of the murine mitochondrial proteome using functionally validated cardiac mitochondria

(2008) Jun Zhang et al.   PROTEOMICS

Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue

(2007) Morris A. Kostiuk et al.   FASEB JOURNAL