DHHC17 Is a New Regulator of AMPK Signaling

AKT Ser/Thr kinase increases V-ATPase–dependent lysosomal acidification in response to amino acid starvation in mammalian cells

(2020) Michael P. Collins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation

(2019) Zhenke Wen et al.   NATURE IMMUNOLOGY

Myristoylation-Dependent Palmitoylation of the Receptor Tyrosine Kinase Adaptor FRS2α

(2019) Barbara Barylko et al.   BIOCHEMISTRY

Protein Partitioning into Ordered Membrane Domains: Insights from Simulations

(2018) Xubo Lin et al.   BIOPHYSICAL JOURNAL

AMPK: Sensing Glucose as well as Cellular Energy Status

(2018) Sheng-Cai Lin et al.   Cell Metabolism

Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies

(2018) Hong Jiang et al.   CHEMICAL REVIEWS

DHHC7 Palmitoylates Glucose Transporter 4 (Glut4) and Regulates Glut4 Membrane Translocation

(2017) Keyong Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamic Protein Acylation: New Substrates, Mechanisms, and Drug Targets

(2017) Thomas Lanyon-Hogg et al.   TRENDS IN BIOCHEMICAL SCIENCES

AMPK as a Therapeutic Target for Treating Metabolic Diseases

(2017) Emily A. Day et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Sudden death due to paralysis and synaptic and behavioral deficits when Hip14/Zdhhc17 is deleted in adult mice

(2016) Shaun S. Sanders et al.   BMC BIOLOGY

Targeting the energy guardian AMPK: another avenue for treating cardiomyopathy?

(2016) Tian Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

LC3/GABARAP family proteins: autophagy-(un)related functions

(2016) Marco B. E. Schaaf et al.   FASEB JOURNAL

ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation

(2016) Patricia Marie-Jeanne Lievens et al.   MOLECULAR AND CELLULAR BIOLOGY

β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase

(2016) Nada Ali et al.   Scientific Reports

S-acylation of the Insulin-Responsive Aminopeptidase (IRAP): Quantitative analysis and Identification of Modified Cysteines

(2015) Martin W. Werno et al.   Scientific Reports

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

(2014) Chen-Song Zhang et al.   Cell Metabolism

Investigation of LKB1 Ser431phosphorylation and Cys433farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

(2013) Vanessa P. Houde et al.   BIOCHEMICAL JOURNAL

What does S-palmitoylation do to membrane proteins?

(2013) Sanja Blaskovic et al.   FEBS Journal

AMPK, insulin resistance, and the metabolic syndrome

(2013) Neil B. Ruderman et al.   JOURNAL OF CLINICAL INVESTIGATION

DHHC17 Palmitoylates ClipR-59 and Modulates ClipR-59 Association with the Plasma Membrane

(2013) W. Ren et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting protein lipidation in disease

(2012) Marilyn D. Resh   TRENDS IN MOLECULAR MEDICINE

Proteomic analysis of protein palmitoylation in adipocytes

(2012) Wenying Ren et al.   Adipocyte

Human DHHC proteins: A spotlight on the hidden player of palmitoylation

(2011) Justyna Korycka et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and  -cell apoptosis

(2011) L. A. Berchtold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMP-activated protein kinase (AMPK)  1 2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise

(2011) H. M. O'Neill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DHHC palmitoyl transferases: substrate interactions and (patho)physiology

(2011) Jennifer Greaves et al.   TRENDS IN BIOCHEMICAL SCIENCES

Palmitoylation of the SNAP25 Protein Family

(2010) Jennifer Greaves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutational Analysis ofSaccharomyces cerevisiaeErf2 Reveals a Two-step Reaction Mechanism for Protein Palmitoylation by DHHC Enzymes

(2010) David A. Mitchell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

(2010) J. S. Oakhill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Palmitoylation regulates raft affinity for the majority of integral raft proteins

(2010) I. Levental et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome

(2009) Bei B. Zhang et al.   Cell Metabolism

Large-scale profiling of protein palmitoylation in mammalian cells

(2009) Brent R Martin et al.   NATURE METHODS

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

MicroRNAs Differentially Regulated by Akt Isoforms Control EMT and Stem Cell Renewal in Cancer Cells

(2009) D. Iliopoulos et al.   Science Signaling

AMP-Activated Protein Kinase: Structure and Regulation

(2008) Pascual Sanz   CURRENT PROTEIN & PEPTIDE SCIENCE

2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitro

(2008) Benjamin C. Jennings et al.   JOURNAL OF LIPID RESEARCH