Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling

Achieving effective and selective CK1 inhibitors through structure modification

(2021) Chenxi Du et al.   Future Medicinal Chemistry

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Gilgamesh (Gish)/CK1γ regulates tissue homeostasis and aging in adult Drosophila midgut

(2020) Shuangxi Li et al.   JOURNAL OF CELL BIOLOGY

Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor

(2020) Tigist Y. Tamir et al.   JOURNAL OF CELL SCIENCE

The Dark Kinase Knowledgebase: an online compendium of knowledge and experimental results of understudied kinases

(2020) Matthew E Berginski et al.   NUCLEIC ACIDS RESEARCH

Cu/Zn Superoxide Dismutase (Sod1) regulates the canonical Wnt signaling pathway

(2020) Bindu Chandrasekharan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3

(2020) Dianrong Li et al.   eLife

WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop

(2019) Megan J. Agajanian et al.   Cell Reports

Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability

(2019) Katrin Strassburger et al.   PLoS One

The Tumor Suppressor SCRIB is a Negative Modulator of the Wnt/β‐Catenin Signaling Pathway

(2019) Avais M. Daulat et al.   PROTEOMICS

SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K

(2019) Carrow Wells et al.   ACS Medicinal Chemistry Letters

Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3

(2019) Song-Yi Lee et al.   Cell Death & Disease

Wnt signaling in development and tissue homeostasis

(2018) Zachary Steinhart et al.   DEVELOPMENT

Kinase inhibitors: the road ahead

(2018) Fleur M. Ferguson et al.   NATURE REVIEWS DRUG DISCOVERY

Efficient proximity labeling in living cells and organisms with TurboID

(2018) Tess C Branon et al.   NATURE BIOTECHNOLOGY

UniProt: a worldwide hub of protein knowledge

(2018)   NUCLEIC ACIDS RESEARCH

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct differentiation of human adipose stem cells into functional hepatocytes

(2017) Jieqiong Huang et al.   Scientific Reports

The contribution of intrinsically disordered regions to protein function, cellular complexity, and human disease

(2016) M. Madan Babu   BIOCHEMICAL SOCIETY TRANSACTIONS

Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay

(2016) Melissa V. Gammons et al.   JOURNAL OF CELL SCIENCE

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium

(2016) C S Daly et al.   ONCOGENE

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds

(2016) Babita Madan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frizzled-Induced Van Gogh Phosphorylation by CK1ε Promotes Asymmetric Localization of Core PCP Factors in Drosophila

(2016) Lindsay K. Kelly et al.   Cell Reports

Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling

(2016) Andres M Lebensohn et al.   eLife

The BioPlex Network: A Systematic Exploration of the Human Interactome

(2015) Edward L. Huttlin et al.   CELL

Genome-wide identification of phospho-regulators of Wnt signaling in Drosophila

(2015) S. Swarup et al.   DEVELOPMENT

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma

(2015) Matthew P. Walker et al.   Science Signaling

FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma

(2015) Matthew P. Walker et al.   Science Signaling

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

Casein kinase 1 and Wnt/β-catenin signaling

(2014) Cristina-Maria Cruciat   CURRENT OPINION IN CELL BIOLOGY

Casein Kinase 1 1 Inhibits the RIG-I/TLR Signaling Pathway through Phosphorylating p65 and Promoting Its Degradation

(2014) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis

(2014) Birgit Schittek et al.   Molecular Cancer

SAINTexpress: Improvements and additional features in Significance Analysis of INTeractome software

(2013) Guoci Teo et al.   Journal of Proteomics

Phosphorylation of Dishevelled by Protein Kinase RIPK4 Regulates Wnt Signaling

(2013) X. Huang et al.   SCIENCE

Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

(2013) H.-W. Rhee et al.   SCIENCE

Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer

(2012) K. D. Proffitt et al.   CANCER RESEARCH

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Wnt/ -Catenin Signaling and AXIN1 Regulate Apoptosis Triggered by Inhibition of the Mutant Kinase BRAFV600E in Human Melanoma

(2012) T. L. Biechele et al.   Science Signaling

PI3K-PKB/Akt Pathway

(2012) B. A. Hemmings et al.   Cold Spring Harbor Perspectives in Biology

The  -Catenin Destruction Complex

(2012) J. L. Stamos et al.   Cold Spring Harbor Perspectives in Biology

Structure-Based Design of Potent and Selective CK1γ Inhibitors

(2012) Hongbing Huang et al.   ACS Medicinal Chemistry Letters

Coordinated Action of CK1 Isoforms in Canonical Wnt Signaling

(2011) B. del Valle-Perez et al.   MOLECULAR AND CELLULAR BIOLOGY

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Regulation of Lrp6 phosphorylation

(2010) Christof Niehrs et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization

(2010) C. Metcalfe et al.   JOURNAL OF CELL SCIENCE

SAINT: probabilistic scoring of affinity purification–mass spectrometry data

(2010) Hyungwon Choi et al.   NATURE METHODS

The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors

(2009) Jean-Remy Courbard et al.   DEVELOPMENTAL BIOLOGY

Inhibition of WNT Signaling by G Protein-Coupled Receptor (GPCR) Kinase 2 (GRK2)

(2009) Liming Wang et al.   MOLECULAR ENDOCRINOLOGY

Inhibition of GSK3 Phosphorylation of β-Catenin via Phosphorylated PPPSPXS Motifs of Wnt Coreceptor LRP6

(2009) Geng Wu et al.   PLoS One

GSK3: a multifaceted kinase in Wnt signaling

(2009) Dianqing Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling

(2008) Shunfu Piao et al.   PLoS One

New Regulators of Wnt/ -Catenin Signaling Revealed by Integrative Molecular Screening

(2008) M. B. Major et al.   Science Signaling