Palmitoylation couples insulin hypersecretion with β cell failure in diabetes

Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes

(2021) Robert Wagner et al.   NATURE MEDICINE

Regulatory effects of protein S-acylation on insulin secretion and insulin action

(2021) Luke H. Chamberlain et al.   Open Biology

Increasing brain palmitoylation rescues behavior and neuropathology in Huntington disease mice

(2021) Amandine Virlogeux et al.   Science Advances

Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study

(2021) Andrea Tura et al.   DIABETES

Nutrient-Induced Metabolic Stress, Adaptation, Detoxification, and Toxicity in the Pancreatic β-Cell

(2020) Marc Prentki et al.   DIABETES

Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes

(2020) Joan Camunas-Soler et al.   Cell Metabolism

Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease

(2020) Xiaochao Wei et al.   CIRCULATION RESEARCH

Obesity, unfavourable lifestyle and genetic risk of type 2 diabetes: a case-cohort study

(2020) Theresia M. Schnurr et al.   DIABETOLOGIA

Protection from β-cell apoptosis by inhibition of TGF-β/Smad3 signaling

(2020) Ji-Hyeon Lee et al.   Cell Death & Disease

Obesity is Associated with Increased Basal and Postprandial β-Cell Insulin Secretion Even in the Absence of Insulin Resistance

(2020) Stephan van Vliet et al.   DIABETES

Single cell transcriptomics of human islet ontogeny defines the molecular basis of β cell dedifferentiation in T2D

(2020) Dana Avrahami et al.   Molecular Metabolism

Large-Scale Analyses Provide No Evidence for Gene-Gene Interactions Influencing Type 2 Diabetes Risk

(2020) Abhishek Nag et al.   DIABETES

Early beta cell dysfunction vs insulin hypersecretion as the primary event in the pathogenesis of dysglycaemia

(2020) Nathalie Esser et al.   DIABETOLOGIA

Proteome-Scale Analysis of Protein S-Acylation Comes of Age

(2020) Yang Wang et al.   JOURNAL OF PROTEOME RESEARCH

Glucolipotoxicity, β-Cells, and Diabetes: The Emperor Has No Clothes

(2019) Gordon C. Weir   DIABETES

β-Cell Failure or β-Cell Abuse?

(2018) Karel Erion et al.   Frontiers in Endocrinology

Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis

(2018) Diane C. Saunders et al.   Cell Metabolism

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

(2018) Anubha Mahajan et al.   NATURE GENETICS

Excess cholesterol inhibits glucose-stimulated fusion pore dynamics in insulin exocytosis

(2017) Yingke Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TrackMate: An open and extensible platform for single-particle tracking

(2017) Jean-Yves Tinevez et al.   METHODS

Neurotrophin Signaling Is Required for Glucose-Induced Insulin Secretion

(2016) Jessica Houtz et al.   DEVELOPMENTAL CELL

Fatty acid synthesis configures the plasma membrane for inflammation in diabetes

(2016) Xiaochao Wei et al.   NATURE

A fluorescent probe for cysteine depalmitoylation reveals dynamic APT signaling

(2016) Rahul S Kathayat et al.   Nature Chemical Biology

Initial hyperinsulinemia and subsequent β-cell dysfunction is associated with elevated palmitate levels

(2016) Johan Staaf et al.   PEDIATRIC RESEARCH

Global profiling of dynamic protein palmitoylation

(2011) Brent R Martin et al.   NATURE METHODS

Regulation of Fusion Pore Closure and Compound Exocytosis in Neuroendocrine PC12 Cells by SCAMP1

(2011) Jie Zhang et al.   TRAFFIC

Site-specific analysis of proteinS-acylation by resin-assisted capture

(2010) Michael T. Forrester et al.   JOURNAL OF LIPID RESEARCH

Glucose stimulation of protein acylation in the pancreatic β-cell

(2010) Mossaad Abdel-Ghany et al.   LIFE SCIENCES

A Practical Guide to Rodent Islet Isolation and Assessment

(2009) Jeffrey D. Carter et al.   BIOLOGICAL PROCEDURES ONLINE

An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol

(2009) Huanting Liu et al.   BMC BIOTECHNOLOGY

Palmitoylation of the synaptic vesicle fusion machinery

(2009) Gerald R. Prescott et al.   JOURNAL OF NEUROCHEMISTRY

Synaptotagmins bind calcium to release insulin

(2008) Benoit R. Gauthier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM